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Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Deeper insight into styrylquinolines' activity spectrum

2013/09/B/NZ7/00423

Keywords:

quinoline antifungal antibacterial drug design,

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ1_2: Biochemistry

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Śląski w Katowicach, Wydział Matematyki, Fizyki i Chemii

woj. śląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Robert Musioł 

Number of co-investigators in the project: 6

Call: OPUS 5 - announced on 2013-03-15

Amount awarded: 643 760 PLN

Project start date (Y-m-d): 2014-03-20

Project end date (Y-m-d): 2017-09-19

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Zestaw chromatografi preparatywnej (100 000 PLN)
  2. komputer osobisty (4 000 PLN)

Information in the final report

  • Publication in academic press/journals (16)
  1. Investigation of the Antimycobacterial Activity of 8-hydroxyquinolines
    Authors:
    57.W. Cieslik, E. Spaczynska, K Malarz, D Tabak, E. Nevin, J. O'Mahony, A Coffey, A Mrozek-Wilczkiewicz, J. Jampilek, R. Musiol
    Academic press:
    Medicinal Chemistry (rok: 2015, tom: 11, strony: 771-779), Wydawca: Bentham
    Status:
    Published
    DOI:
    10.2174/1573406410666150807111703 - link to the publication
  2. New Quinolone Derivative: Spectroscopic Characterization and Reactivity Study by DFT and MD Approaches
    Authors:
    Ranjith, P.K.; Mary, Y.S.; Panicker, C.Y.; Anto, P.L.; Armaković, S.; Armaković, S.J.; Musiol, R.; Jampilek, J.; Van Alsenoy, C.
    Academic press:
    Journal of Molecular Structure (rok: 2017, tom: 1135, strony: 45305), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molstruc.2017.01.045 - link to the publication
  3. Synthesis of new styrylquinoline cellular dyes, fluorescent properties, cellular localization and cytotoxic behavior
    Authors:
    54.M. Rams-Baron, M. Dulski, A. Mrozek-Wilczkiewicz, M. Korzec, W. Cieslik, E. Spaczynska, P. Bartczak, A. Ratuszna, J. Polanski, R. Musiol
    Academic press:
    PLOSOne (rok: 2015, tom: 10, strony: e0131210), Wydawca: PLOS (Public Library of Science)
    Status:
    Published
    DOI:
    10.1371/journal.pone.0131210 - link to the publication
  4. Blocking and dislocation of Candida albicans Cdr1p transporter by styrylquinolines
    Authors:
    J. Szczepaniak, W. Cieslik, A. Krasowska, R. Musiol
    Academic press:
    International Journal of Antimicrobial Agents (rok: 2017, tom: 50, strony: 171-176), Wydawca: Elsevier
    Status:
    Published
    DOI:
    0.1016/j.ijantimicag.2017.01.044 - link to the publication
  5. Design, synthesis and in vitro activity of anticancer styrylquinolines. The p53 independent mechanism of action.
    Authors:
    59.A. Mrozek-Wilczkiewicz, E. Spaczyńska, K. Malarz, W. Cieslik, M. Rams-Baron, V. Krystof, R. Musioł
    Academic press:
    PLOSOne (rok: 2015, tom: 10, strony: e0142678), Wydawca: PLOS (Public Library of Science)
    Status:
    Published
    DOI:
    10.1371/journal.pone.0142678 - link to the publication
  6. Investigation of the spectrum of applicability of quinolineamides
    Authors:
    E. Spaczynska, D. Tabak, K. Malarz, R. Musiol.
    Academic press:
    Der Pharma Chemica (rok: 2014, tom: 6, strony: 233-240), Wydawca: Scholars Research Library
    Status:
    Published
    DOI:
    brak - link to the publication
  7. Iron chelators in photodynamic theraphy revisited: synergistic effect by novel highly active thiosemicarbazones
    Authors:
    A. Mrozek-Wilczkiewicz, M. Serda, R. Musiol, G. Malecki, A. Szurko, A. Muchowicz, J. Golab, A. Ratuszna, J. Polanski.
    Academic press:
    ACS Medicinal Chemistry Letters (rok: 2014, tom: 5, strony: 336-339), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/ml400422a - link to the publication
  8. An overview of quinoline as a privileged scaffold in cancer drug discovery
    Authors:
    Robert Musiol
    Academic press:
    Expert Opinion in Drug Discovery (rok: 2017, tom: 12, strony: 583–597), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1080/17460441.2017.1319357 - link to the publication
  9. Electrolytic copper as cheap and effective catalyst for one-pot triazole synthesis
    Authors:
    Mularski, Jacek Czaplińska, Barbara Cieślik, Wioleta Bebłot, Jakub Bartczak, Piotr Sitko, Rafał Polański, Jarosław Musiol, Robert
    Academic press:
    Scientific Reports (rok: 2018, tom: 8, strony: 4496-4507), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-018-22703- - link to the publication
  10. Small molecule glycoconjugates with anticancer activity
    Authors:
    G. Pastuch-Gawołek, K. Malarz, A. Mrozek-Wilczkiewicz, A. Musioł, M. Serda, B. Czaplinska, R. Musiol
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2016, tom: 112, strony: 130-44), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2016.01.061 - link to the publication
  11. Iron Chelators and Exogenic Photosensitizers. Synergy through Oxidative Stress Gene Expression
    Authors:
    Mrozek-Wilczkiewicz, A.; Malarz, K.; Rams-Baron, M.; Serda, M.; Bauer, D.; Montforts, F.-P.; Ratuszna, A.; Burley, T. T.; Polanski, J. J.; Musiol, R. .
    Academic press:
    Journal of Cancer (rok: 2017, tom: 8, strony: 1979-1987), Wydawca: Ivyspring International Publisher
    Status:
    Published
    DOI:
    10.7150/jca.17959. - link to the publication
  12. Microwave promoted 1,3-dipolar cycloadditions to nitrogen containing heterocycles
    Authors:
    W. Cieslik, M. Serda, R. Musiol
    Academic press:
    Current Organic Chemistry (rok: 2015, tom: 19, strony: 1410-1427), Wydawca: Bentham
    Status:
    Published
    DOI:
    10.2174/1385272819666150518103414 - link to the publication
  13. Quinoline alkaloids against tropical neglected diseases
    Authors:
    R. Musioł, K. Malarz, J. Mularski
    Academic press:
    Current Organic Chemistry (rok: 2019, tom: 21, strony: 1869-1906), Wydawca: Bentham
    Status:
    Published
    DOI:
    10.2174/1385272821666170207103634 - link to the publication
  14. Synergy against fungal pathogens: Working together is better than working alone.
    Authors:
    R.Musioł, A. Mrozek-Wilczkiewicz, J. Polanski.
    Academic press:
    Current Medicinal Chemistry (rok: 2014, tom: 21, strony: 23), Wydawca: Bentham
    Status:
    Published
    DOI:
    10.2174/0929867321666131218094848 - link to the publication
  15. The 8th Central European Conference "Chemistry towards Biology": Snapshot
    Authors:
    A. Perczel, A. G. Atanasov, V. Sklenář, J. Nováček, V. Papoušková, P. Kadeřávek, L. Žídek, H. Kozlowski, J. Wątły, A. Hecel, P. Kołkowska, J. Koča, R. Svobodová-Vařeková, L. Pravda, D. Sehnal, V. Horský, S. Geidl, R. D. Enriz, P. Matějka, A. Jeništová, M. Dendisová, A. Kokaislová, V. Weissig, M. Olsen, A. Coffey, J. Ajuebor, R. Keary, M. Sanz-Gaitero, M. J. Van Raaij, O. McAuliffe, B. Waltenberger, A. Mocan, K. Šmejkal, E. Heiss, M. Diederich, R. Musiol, J. Košmrlj, J. Polanski, J. Jampilek
    Academic press:
    Molecules (rok: 2016, tom: 21, strony: 1381-1408), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules21101381 - link to the publication
  16. Comprehensive exploration of the optical and biological properties of new quinolines based cellular probes
    Authors:
    B. Czaplinska, A. Maron, J. Malecki, G. Szafraniec-Gorol, M Matussek, K. Malarz, A. Mrozek-Wilczkiewicz, W. Danikiewicz, R. Musiol, A. Slodek
    Academic press:
    Dyes and Pigments (rok: 2017, tom: 144, strony: 119-132), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dyepig.2017.05.029 - link to the publication

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