Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Innovative biopreparations with therapeutic activity - chemical and enzymatic methods for production of phospholipids containing isoprenoids and polyphenolic fragments.

2013/09/D/NZ9/02457

Keywords:

phospholipids lipases phospholipases enzymatic modification isoprenoids polyphenols

Descriptors:

  • NZ9_7: Nutrition and food sciences
  • NZ1_9: Biotechnology

Panel:

NZ9 - Fundamentals of applied life sciences and biotechnology: agricultural, forestry, horticulture, animal production and fishery, food and nutrition sciences, industrial biosciences, environmental biotechnology and remediation

Host institution :

Uniwersytet Przyrodniczy we Wrocławiu, Wydział Nauk o Żywności

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Anna Gliszczyńska 

Number of co-investigators in the project: 6

Call: SONATA 5 - announced on 2013-03-15

Amount awarded: 600 000 PLN

Project start date (Y-m-d): 2014-02-18

Project end date (Y-m-d): 2017-02-17

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Wirówka z systemem chłodzenia i zestawem wymiennych rotorów (35 000 PLN)
  2. Waga analityczna (9 000 PLN)
  3. Zestaw do ekstrakcji z fazy stałej (SPE) (18 000 PLN)
  4. Termostatowana wytrząsarka (30 000 PLN)
  5. Bioreaktor o pojemności 2L (90 000 PLN)
  6. Mieszadło magnetyczne z regulacją temperatury (4 000 PLN)
  7. Urządzenie do obróbki danych cyfrowych - komputer.

Information in the final report

  • Publication in academic press/journals (6)
  1. Synthesis and biological evaluation of novel phosphatidylcholine analogues containing monoterpene acids as potent antiproliferative agents
    Authors:
    Gliszczyńska A.*, Niezgoda N., Gładkowski W., Czarnecka M., Świtalska M., Wietrzyk J.
    Academic press:
    PlosOne (rok: 2016, tom: e01572278, strony: 45309), Wydawca: PlosOne
    Status:
    Published
    DOI:
    10.1371/ - link to the publication
  2. Synthesis and evaluation of cytotoxic activity of conjugated linoleic acid derivatives (esters, alcohols and their acetates) towards cancer cell lines
    Authors:
    Natalia Niezgoda, Anna Gliszczyńska, Katarzyna Kempińska, Joanna Wietrzyk , Czesław Wawrzeńczyk
    Academic press:
    European Journal of Lipid Science and Technology (rok: 2017, tom: 119, 1600470, strony: 45302), Wydawca: Wiley-VCH
    Status:
    Published
    DOI:
    10.1002/ejlt.201600470] - link to the publication
  3. Lipase-catalyzed acidolysis of egg-yolk phosphatidylcholine with citronellic acid. New insight into synthesis of isoprenoid-phospholipids.
    Authors:
    Rychlicka M., Niezgoda N., Gliszczyńska A.*
    Academic press:
    Molecules (rok: 2018, tom: 23, 314, strony: 45303), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules23020314 - link to the publication
  4. Isoprenoid-phospholipid conjugates as potential therapeutic agents: synthesis, characterization and antiproliferative studies
    Authors:
    Gliszczyńska A.*, Niezgoda N., Gładkowski W., Świtalska M., Wietrzyk J.
    Academic press:
    PlosOne (rok: 2017, tom: e0172238, strony: 45318), Wydawca: PlosOne
    Status:
    Published
    DOI:
    10.1371/journal.pone.0172238 - link to the publication
  5. Phosphatidylcholine with cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid isomers: synthesis and cytotoxic studies
    Authors:
    Natalia Niezgoda, Anna Gliszczyńska, Witold Gładkowski, Katarzyna Kempińska, Joanna Wietrzyk, Czesław Wawrzeńczyk
    Academic press:
    Australian Journal of Chemistry (rok: 2015, tom: 68, strony: 1065-1075), Wydawca: CSIRO Publishing (Australia)
    Status:
    Published
    DOI:
    10.1071/CH14606 - link to the publication
  6. Synthesis, characterization and in vitro cancer cell growth inhibition evaluation of novel phosphatidylcholines with anisic and veratric acids.
    Authors:
    Czarnecka M., Świtalska M., Wietrzyk J., Maciejewska G., Gliszczyńska A.*
    Academic press:
    Molecules (rok: 2018, tom: 23, 2022, strony: 45306), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules23082022 - link to the publication

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