Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The role of sphingosine-1-phosphate (S1P) receptors signaling in animal model of Parkinson disease. Searching of novel therapeutic targets.

2013/09/N/NZ4/02045

Keywords:

sphingosine-1-phosphate Parkinson disease neuroprotection

Descriptors:

  • NZ4_9: Systems neurobiology
  • NZ7_12: Prevention of human diseases
  • NZ3_7: Signal transduction

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Joanna Motyl 

Number of co-investigators in the project: 2

Call: PRELUDIUM 5 - announced on 2013-03-15

Amount awarded: 95 517 PLN

Project start date (Y-m-d): 2014-03-12

Project end date (Y-m-d): 2017-09-11

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. komputer (3 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (6)
  1. Pramipexole and Fingolimod exert neuroprotection in a mouse model of Parkinson's disease by activation of sphingosine kinase 1 and Akt kinase
    Authors:
    Joanna Motyl; Łukasz Przykaza; Paweł M Boguszewski; Piotr Kosson; Joanna B Strosznajder
    Academic press:
    Neuropharmacology (rok: 2018, tom: 135, strony: 139-150), Wydawca: PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
    Status:
    Published
    DOI:
    10.1016/j.neuropharm.2018.02.023 - link to the publication
  2. Sphingosine kinase 1/sphingosine-1-phosphate receptors dependent signalling in neurodegenerative diseases. The promising target for neuroprotection in Parkinson's disease
    Authors:
    Joanna Motyl; Joanna B Strosznajder
    Academic press:
    Pharmacological Reports (rok: 2018, tom: 70, strony: 1010-1014), Wydawca: POLISH ACAD SCIENCES INST PHARMACOLOGY, SMETNA 12, 31-343 KRAKOW, POLAND
    Status:
    Published
    DOI:
    10.1016/j.pharep.2018.05.002. - link to the publication
  1. P6.3 Neuroprotective Effect Of Fingolimod And Pramipexole In Parkinson's Disease Animal Model
    Authors:
    Motyl J, Przykaza Ł, Kosson P, Boguszewski PM, StrosznajderJB.
    Conference:
    12th International Congress Of The Polish Neuroscience Society (rok: 2015, ), Wydawca: Instytut Biologii Doświadczalnej im. M. Nenckiego PAN, Polskie Towarzystwo Badań Układu Nerwowego
    Data:
    konferencja 6-8.09.2015, Gdańsk, Polska
    Status:
    Published
    DOI:
    link to the publication
  2. Inhibition of pro-apoptotic signalling by fingolimod and pramipexole in Parkinson's disease experimental model
    Authors:
    J. Motyl, P.L. Wencel, J.B. Strosznajder
    Conference:
    29th European College of Neuropsuchopharmacology Congress (rok: 2016, ), Wydawca: Elsevier
    Data:
    konferencja 17-20.09.2016, Wiedeń, Austria
    Status:
    Published
    DOI:
    link to the publication
  3. P.5.c.002 Sphingosine kinase 1 mediated signalling in Parkinson's disease animal model. Neuroprotective effect of fingolimod and a D2/D3 dopamine receptor agonist.
    Authors:
    Motyl J, Przykaza Ł, Kosson P, Boguszewski PM, Strosznajder JB.
    Conference:
    28th European College of Neuropsuchopharmacology Congress (rok: 2015, ), Wydawca: Elsevier Inc.
    Data:
    konferencja 29.08-01.09.2015, Amsterdam, Holandia
    Status:
    Published
  4. P1.29. SPHINGOSINE KINASE-1, THE NEW TARGET IN THE NEUROPROTECTIVE EFFECT OF FINGOLIMOD AND PRAMIPEXOLE IN PARKINSON'S DISEASE ANIMAL MODEL
    Authors:
    Joanna Motyl, Przemysław L. Wencel, Łukasz Przykaza, Piotr Kosson, Paweł M. Boguszewski, Joanna B. Strosznajde
    Conference:
    13th International Congress Of The Polish Neuroscience Society (rok: 2017, ), Wydawca: Instytut Biologii Doświadczalnej im. M. Nenckiego PAN, Polskie Towarzystwo Badań Układu Nerwowego
    Data:
    konferencja 28-31.08.2017.
    Status:
    Published
    DOI:
    link to the publication
  5. Alteration of bioactive sphingolipids signalling and locomotor function in an animal model of Parkinson's disease.Neuroprotective effect of Fingolimod
    Authors:
    Motyl J, Strosznajder JB.
    Conference:
    Neurochemical Conference 2017 Advances in molecular and epigenetic mechanisms in neurodegeneration and neuroinflammation: novel therapeutic approaches" (rok: 2017, ), Wydawca: TERMEDIA PUBLISHING HOUSE LTD, WENEDOW ST 9-1, POZNAN, 61-614, POLAND
    Data:
    konferencja 43027
    Status:
    Published
  6. Sphingolipid signalling in experimental model of Parkinson's disease
    Authors:
    Motyl J 1*, Przykaza Ł, Boguszewski PM, Strosznajder JB.
    Conference:
    Neurochemical Conference 2015; The Days of Neurochemistry; Neuropsychoimmunological mechanisms in the pathology of neurodegenerative diseases: From biomarkers to therapeutics" (rok: 2015, ), Wydawca: TERMEDIA PUBLISHING HOUSE LTD, WENEDOW ST 9-1, POZNAN, 61-614, POLAND
    Data:
    konferencja 22-23.10.2015, Warszawa, Polska
    Status:
    Published
    DOI:
    link to the publication

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