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The role of specific microRNAs (miR-21, miR-29, miR-30 and miR-133a) in the regulation of expression of transforming growth factor beta in the pathogenesis of extracellular matrix fibrosis in patients with dilated cardiomyopathy

2013/09/D/NZ5/00252

Keywords:

microRNA dilated cardiomyopathy extracellular matrix fibrosis

Descriptors:

  • NZ5_1:
  • NZ5_3:
  • NZ5_5:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Krakowski Szpital Specjalistyczny im. Jana Pawła II

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Paweł Piotr Rubiś 

Number of co-investigators in the project: 6

Call: SONATA 5 - announced on 2013-03-15

Amount awarded: 346 740 PLN

Project start date (Y-m-d): 2014-06-09

Project end date (Y-m-d): 2017-06-08

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (9)
  • Articles in post-conference publications (6)
  1. Kinetics of selected serum markers of fibrosis in patients with dilated cardiomyopathy and different grades of diastolic dysfunction of the left ventricle
    Authors:
    Wiśniowska-Śmiałek S, Dziewięcka E, Holcman K, Wypasek E, Khachatryan L, Karabinowska A, Szymonowicz M, Leśniak-Sobelga A, Hlawaty M, Kostkiewicz M, Podolec P, Rubiś P
    Academic press:
    Cardiology Journal (rok: 2020, tom: 27, strony: 726--734), Wydawca: Via Medica
    Status:
    Published
    DOI:
    10.5603/CJ.a2018.0143 - link to the publication
  2. Relationships between circulating galectin-3, extracellular matrix fibrosis and outcomes in dilated cardiomyopathy
    Authors:
    Rubiś P, Holcman K, Dziewięcka E, Wiśniowska-Śmialek S, Wypasek E, Szymonowicz M, Khachatryan L, Karabinowska A, Hlawaty M, Leśniak-Sobelga A, Kostkiewicz M, Garlitski A, Gackowski A, Podolec P
    Academic press:
    Advances in Clinical and Experimental Medicine (rok: 2021, tom: 30, strony: 245-253), Wydawca: Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu
    Status:
    Published
    DOI:
    10.17219/acem/115081 - link to the publication
  3. Prognostic value of fibrosis-related markers in dilated cardiomyopathy: A link between osteopontin and cardiovascular events
    Authors:
    Rubiś P, Wiśniowska-Śmiałek S, Dziewięcka E, Rudnicka-Sosin L, Kozanecki A, Podolec P
    Academic press:
    Advances in Medical Science (rok: 2017, tom: 6; 63(1), strony: 160-166), Wydawca: Elsevier
    Status:
    Published
  4. Relations between circulating and myocardial fibrosis-linked microRNAs with left ventricular reverse remodeling in dilated cardiomyopathy
    Authors:
    Dziewięcka E, Totoń-Żurańska J, Wołkow P, Kołton-Wróż M, Pitera E, Wiśniowska-Śmiałek S, Khachatryan L, Karabinowska A, Szymonowicz M, Podolec P, Rubiś P
    Academic press:
    Advances in Clinical and Experimental Medicine (rok: 2020, tom: 29, strony: 285-293), Wydawca: Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu
    Status:
    Published
    DOI:
    10.17219/acem/115088 - link to the publication
  5. Right ventricular morphology and function is not related with microRNAs and fibrosis markers in dilated cardiomyopathy
    Authors:
    Paweł Rubiś, Justyna Totoń-Żurańska, Sylwia Wiśniowska-Śmiałek, Maria Kołton-Wróż, Paweł Wołkow, Ewa Wypasek, Lucyna Rudnicka-Sosin, Agnieszka Pawlak, Artur Kozanecki, Lidia Tomkiewicz-Pająk, Piotr Podolec
    Academic press:
    Cardiology Journal (rok: 2018, tom: 25(6), strony: 722-731), Wydawca: Via Medica
    Status:
    Published
    DOI:
    10.5603/CJ.a2017.0099 - link to the publication
  6. Relationships between circulating galectin-3, extracellular matrix fibrosis and outcomes in dilated cardiomyopathy
    Authors:
    Rubiś P, Holcman K, Dziewięcka E, Wiśniowska-Śmialek S, Wypasek E, Szymonowicz M, Khachatryan L, Karabinowska A, Hlawaty M, Leśniak-Sobelga A, Kostkiewicz M, Garlitski A, Gackowski A, Podolec P
    Academic press:
    Advances in Clinical and Experimental Medicine (), Wydawca: Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu
    Status:
    Published
    DOI:
    10.17219/acem/115081 - link to the publication
  7. Fibrosis of extracellular matrix is related to the duration of the disease but is unrelated to the dynamics of collagen metabolism in dilated cardiomyopathy
    Authors:
    Rubiś P, Wisniowska-Smialek S, Wypasek E, Biernacka-Fijalkowska B, Rudnicka-Sosin L, Dziewiecka E, Faltyn P, Khachatryan L, Karabinowska A, Kozanecki A, Tomkiewicz-Pajak L, Podolec P
    Academic press:
    Inflammation Reaserch (rok: 2016, tom: 65, strony: 941-949), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00011-016-0977-3 - link to the publication
  8. Relationships between left ventricular geometry (sphericity index) and remodeling in dilated cardiomyopathy
    Authors:
    Dziewięcka E, Wiśniowska-Śmiałek S, Khachatryan L, Karabinowska A, Szymonowicz M, Podolec P, Rubiś P
    Academic press:
    Minerva Cardioangiologica (rok: 2019, tom: 67, strony: 261-271), Wydawca: EDIZIONI MINERVA MEDICA
    Status:
    Published
    DOI:
    10.23736/S0026-4725.19.04856-4 - link to the publication
  9. Twelve-month kinetics of circulating fibrosis-linked microRNAs (miR-21, miR-29, miR-30, and miR-133a) and the relationship with extracellular matrix fibrosis in dilated cardiomyopathy
    Authors:
    Rubiś P, Totoń-Żurańska J, Kołton-Wróż M, Wołkow P, Pitera E, Wiśniowska-Śmiałek S, Dziewięcka E, Garlitski A, Podolec P
    Status:
    Accepted for publication
  1. Fibrosis of extracellular matrix is inversely related with left ventricular volumes in dilated cardiomyopathy
    Authors:
    P. Rubis, S. Wisniowska-Smialek, L. Rudnicka-Sosin, B. Biernacka-Fijalkowska, E. Dzwiecka, P. Faltyn, A. Karabinowska, L. Khachatryan, A. Kozanecki, P. Podolec
    Conference:
    doroczny kongres Europejskiego Towarzystwa Kardiologicznego (ang. European Society of Cardiology) w Rzymie, Włochy (rok: 2016, ), Wydawca: Oxford Academic
    Data:
    konferencja 27-31 sierpień
    Status:
    Published
  2. Comparison of 12-month kinetics of serum markers of collagen synthesis, transforming growth factor and connective tissue growth factor between patients with recent and chronic dilated cardiomyopathy
    Authors:
    P. Rubiś, S. Wisniowska-Smialek, E. Wypasek, E. Dziewiecka, P. Faltyn, L. Khachatryan, A. Karabinowska, P. Podolec
    Conference:
    Kongres Asocjacji Niewydolności Serca Europejskiego Towarzystwa Kardiologicznego. Paryż, Francja (rok: 2017, ), Wydawca: European Journal of Heart Failure
    Data:
    konferencja 29/04/2017 - 02/05/2017
    Status:
    Published
  3. Panel of serum markers of fibrosis does not contribute to prognosis in dilated cardiomyopathy
    Authors:
    P. Rubiś, S. Wisniowska-Smialek, E. Dziewiecka, K. Holcman, P. Faltyn, L. Khachatryan, A. Karabinowska, A. Kozanecki, E. Wypasek P. Podolec
    Conference:
    Kongres Asocjacji Niewydolności Serca Europejskiego Towarzystwa Kardiologicznego. Paryż, Francja (rok: 2017, ), Wydawca: European Journal of Heart Failure
    Data:
    konferencja 29/04/2017 - 02/05/2017
    Status:
    Published
  4. Regardless of the fibrosis status 12-month kinetics of serum markers of fibrosis are not different in dilated cardiomyopathy patients
    Authors:
    P. Rubiś, S. Wisniowska-Smialek, E. Dziewiecka, K. Holcman, P. Faltyn, L. Khachatryan, A. Karabinowska, E. Wypasek P. Podolec
    Conference:
    Kongres Asocjacji Niewydolności Serca Europejskiego Towarzystwa Kardiologicznego. Paryż, Francja. (rok: 2017, ), Wydawca: European Journal of Heart Faiilure
    Data:
    konferencja 29/04/2017 - 02/05/2017
    Status:
    Published
  5. Relations between left ventricular reverse remodeling and serum markers of extracellular matrix fibrosis in dilated cardiomyopathy
    Authors:
    S Wisniowska-Smialek, P Rubis, L Khachatryan, A Karabinowska, P Faltyn, E Dziewiecka, B Biernacka-Fialkowska, M Hlawaty, M Kostkiewicz, P Podolec
    Conference:
    EuroEcho-Imaging 2016 (rok: 2016, ), Wydawca: Oxford Academic
    Data:
    konferencja 7-10 grudnia
    Status:
    Published
  6. Comparison of endomyocardial biopsy results between early and late dilated cardiomyopathy
    Authors:
    P. Rubis, S. Wisniowska-Smialek, L. Rudnicka-Sosin, B. Biernacka-Fijalkowska, A. Kozanecki, P. Podolec
    Conference:
    doroczny kongres Europejskiego Towarzystwa Kardiologicznego (ang. European Society of Cardiology) w Rzymie, Włochy (rok: 2016, ), Wydawca: Oxford Academic
    Data:
    konferencja 27-31 sierpień
    Status:
    Published