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Contribution of Bcl-2 proteins and melanocyte/melanoma-specific transcription factor MITF to melanoma cell survival under microenvironmental pressure

2013/09/N/NZ1/01025

Keywords:

melanoma Bcl-2 proteins MITF

Descriptors:

  • NZ1_1: Molecular biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Mariusz Hartman 

Number of co-investigators in the project: 3

Call: PRELUDIUM 5 - announced on 2013-03-15

Amount awarded: 116 610 PLN

Project start date (Y-m-d): 2014-02-10

Project end date (Y-m-d): 2016-06-09

Project duration:: 28 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (3)
  1. MCL-1, BCL-XL and MITF are diversely employed in adaptive response of melanoma cells to changes in microenvironment
    Authors:
    Hartman ML, Talar B, Gajos-Michniewicz A, Czyz M
    Academic press:
    PLoS ONE (rok: 2015, tom: 10(6), strony: e0128796), Wydawca: The Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0128796 - link to the publication
  2. Pro-survival role of MITF in melanoma
    Authors:
    Hartman ML, Czyz M
    Academic press:
    Journal of Investigative Dermatology (rok: 2015, tom: 135, strony: 352-358), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/jid.2014.319 - link to the publication
  1. Immediate and long-term molecular response of melanoma cells to changes in microenvironment
    Authors:
    Hartman ML, Sztiller-Sikorska M, Talar B, Gajos-Michniewicz A, Czyz M
    Conference:
    18th Gliwice Scientific Meetings (rok: 2014, ), Wydawca: bd.
    Data:
    konferencja 21-22 listopada
    Status:
    Published
  2. Diverse pro-survival responses of heterogeneous melanoma cell lines to changes in microenvironment
    Authors:
    Hartman M, Talar B, Gajos-Michniewicz A, Czyz M
    Conference:
    Cell Death Signaling in Cancer and the Immune System (rok: 2014, ), Wydawca: Keystone Symposia on Molecular and Cellular Biology
    Data:
    konferencja 28 października - 2 listopada
    Status:
    Published
  3. MCL-1 protects patient-derived melanoma cells from death during rapid changes in microenvironment
    Authors:
    Hartman M, Gajos-Michniewicz A, Talar B, Czyz M
    Conference:
    A Matter of Life or Death: Mechanisms and Relevance of Cell Death for Cancer Biology and Treatment (rok: 2016, ), Wydawca: European Association for Cancer Research
    Data:
    konferencja 28-30 stycznia
    Status:
    Published

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