Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Role of epigenetic mechanisms in glioma patobiology

2013/09/B/NZ3/01402

Keywords:

glioma epigenetics histone modifications DNA methylation chromatin modifying enzymes

Descriptors:

  • NZ3_5: Molecular neurobiology
  • NZ3_1: Cell biology
  • NZ3_2: Cell physiology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marta Maleszewska-Bobińska 

Number of co-investigators in the project: 4

Call: OPUS 5 - announced on 2013-03-15

Amount awarded: 690 000 PLN

Project start date (Y-m-d): 2014-02-06

Project end date (Y-m-d): 2018-01-05

Project duration:: 47 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Stanowisko komputerowe + oprogramowanie + drukarka (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (8)
  1. Histone deacetylase inhibitors exert anti-tumor effects on human adherent and stem-like glioma cells.
    Authors:
    Was Halina, Krol Sylwia K., Rotili Dante, Mai Antonello, Wojtas Bartosz, Kaminska Bozena, Maleszewska Marta
    Academic press:
    Clinical Epigenetics (rok: 2019, tom: 11, strony: 11), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s13148-018-0598-5 - link to the publication
  2. Deregulation of histone-modifying enzymes and chromatin structure modifiers contributes to glioma development.
    Authors:
    Maleszewska Marta, Kaminska Bozena
    Academic press:
    Future Oncology (rok: 2015, tom: 11, strony: 2587-601), Wydawca: Future Medicine
    Status:
    Published
    DOI:
    10.2217/fon.15.171 - link to the publication
  1. Antitumor effects of pharmacological and genetic ablation of selected histone modifying enzymes in human glioma cells
    Authors:
    Sylwia K. Król, Marta Maleszewska, Bartosz Wojtaś, Bożena Kamińska
    Conference:
    Brain Tumors 2016 - from biology to therapy (rok: 2016, ), Wydawca: Brain Tumors 2016
    Data:
    konferencja 27-29.06.2016
    Status:
    Published
  2. Profiling of epigenetic enzyme expression in glioblastoma cells reveals transcriptional downregulation of epigenetics modulators
    Authors:
    Marta Maleszewska, Bartosz Wojtas, Sylwia K. Krol, Bartlomiej Gielniewski, Bozena Kaminska
    Conference:
    Brain Tumor 2015 (rok: 2015, ), Wydawca: Max Delbruck Communications Center
    Data:
    konferencja 28-29.05.2015
    Status:
    Published
  3. Glioblastoma epigenetic landscape is controlled by E2F1/E2F4 transcription factors
    Authors:
    Bartosz Wojtaś, Marta Maleszewska, Bartłomiej Gielniewski, Jakub Mieczkowski, Michał Dąbrowski, Sam Mondal, Janusz Siedlecki, Mateusz Bujko, Paweł Naumann, Wiesława Grajkowska, Katarzyna Kotulska, Bozena Kaminska
    Conference:
    Inteligent Systems for Molecular Biology and the European Conference on Computational Biology 2017 (rok: 2017, ), Wydawca: ISMB/ECCB
    Data:
    konferencja 21-25 Lipca 2017
    Status:
    Published
    DOI:
    link to the publication
  4. Global deregulation of epigenetic enzyme/modifier expression in glioblastoma is driven by the aberrant expression of E2F1/E2F4 transcription factors
    Authors:
    Marta Maleszewska, Bartosz Wojtas, Bartlomiej Gielniewski, Jakub Mieczkowski, Michał Dabrowski, Shamba Mondal, Janusz Siedlecki, Mateusz Bujko, Paweł Naumann, Wiesława Grajkowska, Katarzyna Kotulska, Bozena Kaminska
    Conference:
    Epigenomics of Common Diseases (rok: 2017, ), Wydawca: Wellcome Genome Campus
    Data:
    konferencja 14-17 Listopada 2017
    Status:
    Published
  5. Targeted enrichment sequencing of the large genomic region in glioblastoma
    Authors:
    Wojtas Bartosz, Gielniewski Bartlomiej, Maleszewska Marta, Bujko Mateusz, Siedlecki Janusz, Kotulska Katarzyna, Grajkowska Wieslawa, Kaminska Bozena
    Conference:
    19th Annual International Conference on Research in Computational Molecular Biology (rok: 2015, ), Wydawca: RECOMB
    Data:
    konferencja 12-15.04.2015
    Status:
    Published
  6. Targeted sequencing of cancer- and epigenetics-related genes in glioblastoma reveals a deep deregulation of epigenetic mechanisms
    Authors:
    Bartłomiej Gielniewski, Bartosz Wojtaś, Marta Maleszewska, Andrzej Marchel, Tomasz Czernicki, Andrzej Koziarski, Grzegorz Zieliński, Andrzej Styk, Maciej Kawecki, Cezary Szczylik, Ryszard Czepko, MAciej Banach, Wojciech Kaspera, Wojciech Szopa, Bozena Kaminska
    Conference:
    Brain Tumors 2016 - from biology to therapy (rok: 2016, ), Wydawca: Brain Tumors 2016
    Data:
    konferencja 27-29.06.2016
    Status:
    Published
  7. Epigenetic enzymes an new therapeutic targets for therapy of glioblastoma
    Authors:
    Król Sylwia K., Maleszewska Marta, Kaminska Bozena
    Conference:
    EurocanPlatform Summer School in Translational Cancer Research (rok: 2015, ), Wydawca: EurocanPlatform
    Data:
    konferencja 12-16.10.2015
    Status:
    Published
  8. Targeted sequencing of cancer- and epigenetics-related genes in glioblastoma reveals a deep deregulation of epigenetic mechanisms
    Authors:
    Bartosz Wojtaś, Marta Maleszewska, Bartłomiej Gielniewski, Bożena Kamińska
    Conference:
    Epigenetics of common diseases (rok: 2015, ), Wydawca: Weelome Genome Campus Conference Centre
    Data:
    konferencja 6-9.11.2015
    Status:
    Published

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