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The role of collagen receptors, alpha1beta1 and alpha2beta1 integrins in asthma airway inflammation and remodeling - a look into the bronchial tree.

2013/09/B/NZ5/00758

Keywords

Descriptors

  • NZ5_3: Patogeneza chorób człowieka
  • NZ5_5: Diagnostyka chorób człowieka

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Lekarski

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Stanisława Bazan-Socha

Number of co-investigators in the project: 10

Call

OPUS 5 – announced on 2013-03-15

Amount awarded
622 100 PLN
Project start date
2014-03-03
Project end date
2018-03-02
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Information in the final report

Publication in academic press/journals (2)

  1. Reticular Basement Membrane Thickness Is Associated with Growth- and Fibrosis-Promoting Airway Transcriptome Profile-Study in Asthma Patients

    Authors:
    Stanislawa Bazan-Socha, Sylwia Buregwa-Czuma, Bogdan Jakiela, Lech Zareba, Izabela Zawlik, Aleksander Myszka, Jerzy Soja, Krzysztof Okon, Jacek Zarychta, Paweł Kozlik, Sylwia Dziedzina, Agnieszka Padjas, Krzysztof Wojcik, Michal Kepski, Jan G. Bazan
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 22 (3), pages: 998), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22030998 – link to the publication

  2. Interactions via α2β1 Cell Integrin May Protect against the Progression of Airway Structural Changes in Asthma

    Authors:
    Stanislawa Bazan-Socha, Bogdan Jakiela, Joanna Zuk, Jacek Zarychta, Jerzy Soja, Krzysztof Okon, Sylwia Dziedzina, Lech Zareba, Jerzy Dropinski, Krzysztof Wojcik, Agnieszka Padjas, Cezary Marcinkiewicz, Jan G. Bazan
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 22 (12), pages: 6315), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22126315 – link to the publication

Articles in post-conference publications (5)

  1. Impaired fibrinolysis and lower levels of plasma α2-macroglobulin are associated with an increased risk of severe asthma exacerbations

    Authors:
    Stanislawa Bazan-Socha, Lucyna Mastalerz, Agnieszka Cybulska, Lech Zareba, Romy Kremers, Michal Zabczyk, Grazyna Pulka, Teresa Iwaniec, Coenraad Hemker, Anetta Undas
    Conference:
    American Thoracic Society International Conference 2017 (year: 2017, pages: Abstract No 7292), Publisher: American Thoracic Society
    Date:
    conference 19-24 May 2017
    Status:
    Published

  2. Impaired fibrinolysis and lower levels of plasma a2-macroglobulin are associated with an increased risk of severe asthma exacerbations

    Authors:
    Cybulska A., Bazan-Socha S., Mastalerz L., Zareba L., Kremers R., Zabczyk M., Pulka G., Iwaniec T., Hemker C., Undas A.
    Conference:
    European Academy of Allergy and Clinical Immunology Congress 2017 (year: 2017, pages: Abstract No 331), Publisher: European Academy of Allergy and Clinical Immunology
    Date:
    conference 17-21 June 2017
    Status:
    Published

  3. Relationship of airway structural changes and lung function abnormalities with blood and BAL biomarkers in asthma

    Authors:
    S. Bazan-Socha, J. Zuk, P. Kozlik, J. Zarychta, K. Okon, L. Zareba, J. Bazan, J. Soja, J. Musial
    Conference:
    European Respiratory Society 2019 International Congress (year: 2019, pages: Abstract No 15800), Publisher: ERS
    Date:
    conference 28.09-02.10.2019
    Status:
    Published

  4. Airway transcriptome profile determining increased reticular basement membrane thickness in asthma patients

    Authors:
    Bazan-Socha S, Buregwa-Czuma S, Jakiela B, Zareba L, Zawlik I, Myszka A, Soja J, Okon K, Zarychta J, Kozlik P, Dziedzina S, Padjas A, Wojcik K, Kepski M, Bazan J
    Conference:
    EAACI Hybrid Congress 2021 (year: 2021, pages: Abstract No 265), Publisher: European Academy of Allergy and Clinical Immunology
    Date:
    conference 10-12.07
    Status:
    Published

  5. Citrullinated histone H3 is increased in blood of asthma subjects

    Authors:
    P. Kuczia, J. Żuk, T. Iwaniec, J. Zarychta, J. Soja, S. Bazan-Socha
    Conference:
    European Respiratory Society 2019 International Congress (year: 2019, pages: Abstract No 19883), Publisher: European Respiratory Society
    Date:
    conference 28.09-02.10.2019
    Status:
    Published

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