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Information on the principal investigator and host institution

Information of the project and the call

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Evaluation of influence of genetic factors associated with transport and metabolizm of immunosuppressive agents on blood levels of immunosuppressants and their metabolites in patients on immunosuppressive therapy with application of liquid chromatography with mass spectrometry (LC/MS/MS).

2013/09/B/NZ2/00275

Keywords:

immunosuppressive agents transplantation autoimmune diseases pharmacogenetics drug metabolism

Descriptors:

  • NZ2_1: Molecular genetics
  • NZ2_4: Metabolomics
  • NZ5_7: Human disease treatment

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Warszawski Uniwersytet Medyczny, I Wydział Lekarski

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Leszek Pączek 

Number of co-investigators in the project: 12

Call: OPUS 5 - announced on 2013-03-15

Amount awarded: 1 096 900 PLN

Project start date (Y-m-d): 2014-02-10

Project end date (Y-m-d): 2017-12-09

Project duration:: 46 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (10)
  1. Dose-adjusted and dose/kg-adjusted concentrations of mycophenolic acid precursors reflect metabolic ratios of their metabolites in contrast with tacrolimus and cyclosporine
    Authors:
    Ewa Hryniewiecka , Jolanta Zegarska, Dorota Zochowska, Emilia Samborowska, Radoslaw Jazwiec, Maciej Kosieradzki, Slawomir Nazarewski, Michal Dadlez, Leszek Paczek
    Academic press:
    Bioscience Reports (rok: 2019, tom: 39(9), strony: BSR20182031), Wydawca: Portland Press
    Status:
    Published
    DOI:
    10.1042/BSR20182031 - link to the publication
  2. Lack of Relationship Between Renal Function and Genetic Variants of CYP3A4, CYP3A5, MDR1, MRP2, UGT1A9, UGT1A8, and UGT2B7 in Patients After Liver Transplantation in a 2-Year Follow-up
    Authors:
    Ewa Hryniewiecka, Jolanta Zegarska, Dorota Zochowska, Leszek Pączek
    Academic press:
    Transpl Proc (rok: 2020, tom: 52(8), strony: 2487-2491), Wydawca: Elsevier Inc.
    Status:
    Published
    DOI:
    10.1016/j.transproceed.2020.01.096. - link to the publication
  3. Tacrolimus metabolite M-III may have nephrotoxic and myelotoxic effect and increase the incidence of infections in kidney transplant recipients
    Authors:
    Żegarska Jolanta, Hryniewiecka Ewa, Żochowska Dorota, Samborowska Emilia, Jaźwiec Radosław, Borowiec Agnieszka, Tszyrsznic Włodzimierz, Chmura Andrzej, Nazarewski Sławomir, Dadlez Michał, Pączek Leszek
    Academic press:
    Transplantation Proceedings (rok: 2016, tom: 48(5), strony: 1539-42), Wydawca: New York, N.Y. : Elsevier Science Inc.
    Status:
    Published
    DOI:
    10.1016/j.transproceed.2015.12.133 - link to the publication
  4. Cyclosporine Metabolites' Metabolic Ratios May Be Markers of Cardiovascular Disease in Kidney Transplant Recipients Treated with Cyclosporine A-Based Immunosuppression Regimens
    Authors:
    Ewa Hryniewiecka, Jolanta Żegarska, Dorota Żochowska, Emilia Samborowska, Radosław Jaźwiec, Maciej Kosieradzki, Sławomir Nazarewski, Michał Dadlez, Leszek Pączek
    Academic press:
    Cardiovascular Toxicology (rok: 2018, tom: 19(3), strony: 255-263), Wydawca: Springer Science+Business Media, LLC,
    Status:
    Published
    DOI:
    10.1007/s12012-018-9492-9 - link to the publication
  5. Determination of the concentrations of azathioprine metabolites, 6-thioguanine and 6- methylmercaptopurine, in whole blood with the use of liquid chromatography combined with mass spectrometry.
    Authors:
    Żochowska Dorota, Żegarska Jolanta, Hryniewiecka Ewa, Samborowska Emilia, Jaźwiec Radosław, Tszyrsznic Włodzimierz, Borowiec Agnieszka, Dadlez Michał, Pączek Leszek
    Academic press:
    Transplantation Proceedings (rok: 2016, tom: 48(5), strony: 1836-9), Wydawca: New York, N.Y. : Elsevier Science Inc.
    Status:
    Published
    DOI:
    10.1016/j.transproceed.2016.01.084 - link to the publication
  6. Hydroxylated, hydroxymethylated, dihydroxylated and trihydroxylated cyclosporine A metabolites can be nephrotoxic in kidney transplant recipients.
    Authors:
    Hryniewiecka Ewa, Żegarska Jolanta, Żochowska Dorota, Jaźwiec Radosław, Borowiec Agnieszka, Samborowska Emilia, Tszyrsznic Włodzimierz, Dadlez Michał, Pączek Leszek
    Academic press:
    Transplantation Proceedings (rok: 2016, tom: 48(5), strony: 1551-5), Wydawca: New York, N.Y. : Elsevier Science Inc.
    Status:
    Published
    DOI:
    10.1016/j.transproceed.2016.01.090 - link to the publication
  7. Evaluation of the relationship between concentrations of tacrolimus metabolites, 13-O-demethyl tacrolimus and 15-O-demethyl tacrolimus, and clinical and biochemical parameters in kidney transplant recipients
    Authors:
    Jolanta Zegarska; Ewa Hryniewiecka; Dorota Zochowska; Emilia Samborowska ; Radoslaw Jazwiec; Maciej Kosieradzki; Slawomir Nazarewski; Michal Dadlez; Leszek Paczek
    Academic press:
    Transplantation Proceedings (rok: 2018, tom: 50(7), strony: 2235-2239), Wydawca: Elsevier Science nc.
    Status:
    Published
    DOI:
    10.1016/j.transproceed.2018.03.025 - link to the publication
  8. Cardiovascular disease in kidney transplantation and its association with blood concentrations of cyclosporine and cyclosporine metabolites
    Authors:
    Ewa Hryniewiecka; Jolanta Zegarska; Dorota Zochowska,; Emilia Samborowska; Radoslaw Jazwiec; Maciej Kosieradzki; Slawomir Nazarewski; Michal Dadlez; Leszek Paczek
    Academic press:
    Transplantation Proceedeings (rok: 2018, tom: 50(6), strony: 1850-1854), Wydawca: Elsevier Science Inc.
    Status:
    Published
    DOI:
    10.1016/j.transproceed.2018.03.115 - link to the publication
  9. Higher Concentrations of Cyclosporine Metabolites in Liver Transplant Recipients With a History of Viral and Bacterial Infections
    Authors:
    Jolanta Zegarska, Ewa Hryniewiecka, Dorota Zochowska, Emilia Samborowska, Radoslaw Jazwiec, Michal Dadlez, Leszek Paczek
    Academic press:
    Transpl Proc (rok: 2020, tom: 52(8), strony: 2503-2506), Wydawca: Elsevier Inc.
    Status:
    Published
    DOI:
    10.1016/j.transproceed.2020.03.039. - link to the publication
  10. Worsening of Kidney Transplant Function During 2-Year Follow-up Is Associated With the Genetic Variants of CYP3A4, MDR1, and UGT1A9
    Authors:
    Ewa Hryniewiecka*, Jolanta Zegarska, Dorota Zochowska, Leszek Pączek
    Academic press:
    Transpl Proc (rok: 2020, tom: 52(8), strony: 2363-2367), Wydawca: Elsevier Inc.
    Status:
    Published
    DOI:
    10.1016/j.transproceed.2020.02.088. - link to the publication

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