Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of a SNAIL1 transcription factor in the pathogenesis of non-epithelial tumors.

2013/09/B/NZ5/00769

Keywords:

SNAIL1 oncogenesis rhabdomyosarcoma differentiation miRNA

Descriptors:

  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Lekarski

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marcin Majka 

Number of co-investigators in the project: 6

Call: OPUS 5 - announced on 2013-03-15

Amount awarded: 1 227 560 PLN

Project start date (Y-m-d): 2014-02-13

Project end date (Y-m-d): 2017-08-12

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Termoblok i termomikser z wymiennymi blokami 1,5ml i 0,5ml (18 000 PLN)
  2. Wytrząsarka (25 000 PLN)
  3. Inkubator komórkowy (50 000 PLN)
  4. Mikroskop-Holomonitor M4 and komputer (85 000 PLN)
  5. Elektroporator komórkowy Neon (Invitrogen) (35 000 PLN)
  6. Kamera CCD z oprogramowaniem i komputerem (65 000 PLN)
  7. Zestaw pipet (12 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (10)
  1. Constitutive activation of MET signaling impairs myogenic differentiation of rhabdomyosarcoma and promotes its development and progression.
    Authors:
    Skrzypek K, Kusienicka A, Szewczyk B, Adamus T, Lukasiewicz E, Miekus K, Majka M.
    Academic press:
    Oncotarget (rok: 2015, tom: 6, strony: 31378-31398), Wydawca: Impact Journals, LLC
    Status:
    Published
    DOI:
    10.18632/oncotarget.5145 - link to the publication
  2. SNAIL is a key regulator of alveolar rhabdomyosarcoma tumor growth and differentiation through repression of MYF5 and MYOD function
    Authors:
    Skrzypek K, Kusienicka A, Trzyna E, Szewczyk B, Ulman A, Konieczny P, Adamus T, Badyra B, Kortylewski M, Majka M.
    Academic press:
    Cell Death Disease (rok: 2018, tom: 9, strony: 643), Wydawca: Springer Nature CDD press
    Status:
    Published
    DOI:
    10.1038/s41419-018-0693-8 - link to the publication
  3. Targeting MET Receptor in Rhabdomyosarcoma: Rationale and Progress.
    Authors:
    Barbara Szewczyk, Klaudia Skrzypek, Marcin Majka
    Academic press:
    Current Drug Targets (rok: 2017, tom: 18, strony: 95-105), Wydawca: Bentham Science Publishers
    Status:
    Published
    DOI:
    10.2174/138945011766615120912 - link to the publication
  1. Generation of TALEN and CRISPR/Cas9 nucleases targeting SNAI1 gene and microRNA
    Authors:
    Klaudia Skrzypek, Aleksandra Ulman, Barbara Szewczyk, Claudio Mussolino, Toni Cathomen, Marcin Majka
    Conference:
    Genome Editing for Gene and Cell Therapy, a Herrenhausen Symposium (rok: 2016, ), Wydawca: Volkswagen Foundation and Nature Medicine
    Data:
    konferencja 03-04.11
    Status:
    Published
    DOI:
    link to the publication
  2. Targeting MET for a differentiation therapy of rhabdomyosarcoma
    Authors:
    Klaudia Skrzypek, Anna Jagiełło, Barbara Szewczyk, Tomasz Adamus, Katarzyna Miękus, Marcin Majka
    Conference:
    26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics (rok: 2014, ), Wydawca: European Journal of Cancer
    Data:
    konferencja 18-21.11.2014
    Status:
    Published
    DOI:
    link to the publication
  3. The effect of SNAIL transcription factor on microRNA and small RNA expression profile in rhabdomyosarcoma
    Authors:
    Klaudia Skrzypek. Marcin Majka
    Conference:
    Eukaryotic RNA turnover (rok: 2017, ), Wydawca: EMBO Press oraz University of Oxford
    Data:
    konferencja 10-13.07.2017
    Status:
    Published
  4. Genome editing in tumor and iPS cells for the study of SNAI1 role in human diseases
    Authors:
    Klaudia Skrzypek, Aleksandra Ulman, Bogna Badyra, Maciej Sulkowski, Marcin Majka
    Conference:
    6th Central European Congress of Life Sciences Eurobiotech (rok: 2017, ), Wydawca: Targi w Krakowie Ltd.
    Data:
    konferencja 11-14.09.2017
    Status:
    Published
  5. Generation of skeletal muscle cells form human iPS cells
    Authors:
    Aleksandra Ulman, Klaudia Skrzypek, Barbara Szewczyk, Marcin Majka
    Conference:
    Progress in Developmental Biology (rok: 2017, ), Wydawca: Polska Akademia Umiejętności
    Data:
    konferencja 26.05.2017
    Status:
    Published
  6. Inactivation of SNAI1 gene in rhabdomyosarcoma cells by CRISPR/Cas9 nucleases
    Authors:
    Marcin Majka, Aleksandra Ulman, Klaudia Skrzypek, Barbara Szewczyk, Claudio Mussolino, Toni Cathomen
    Conference:
    Genome Editing for Gene and Cell Therapy, a Herrenhausen Symposium (rok: 2016, ), Wydawca: Volkswagen Foundation and Nature Medicine
    Data:
    konferencja 03-04.11
    Status:
    Published
  7. SNAIL transcription factor is a novel regulator of rhabdomyosarcoma differentiation
    Authors:
    Klaudia Skrzypek, Anna Kusienicka, Barbara Szewczyk, Elzbieta Trzyna, Tomasz Adamus, Marcin Majka
    Conference:
    44th European Muscle Conference (rok: 2015, ), Wydawca: Springer
    Data:
    konferencja 21-25.09.2015
    Status:
    Published
    DOI:
    link to the publication
  8. Two faces of transcription factor SNAIL
    Authors:
    Klaudia Skrzypek, Anna Kusienicka, Elzbieta Trzyna, Barbara Szewczyk, Tomasz Adamus, Marcin Kortylewski, Marcin Majka
    Conference:
    2nd Congress BIO 2016 Expanding beyond the limits" (rok: 2016, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 13-16.09
    Status:
    Published
  9. SNAI1 gene disruption in rhabdomyosarcoma cells using CRISPR/Cas9 and TALEN nucleases
    Authors:
    1.Klaudia Skrzypek, Aleksandra Ulman, Barbara Szewczyk, Claudio Mussolino, Toni Cathomen, Marcin Majka
    Conference:
    7th European Congress on Biotechnology (rok: 2016, ), Wydawca: New Biotechnology
    Data:
    konferencja 03-06.07
    Status:
    Published
    DOI:
    link to the publication
  10. SNAIL-microRNA axis regulates rhabdomyosarcoma development
    Authors:
    Klaudia Skrzypek. Anna Kusienicka, Elzbieta Trzyna, Marcin Majka
    Conference:
    Progress in Developmental Biology (rok: 2017, ), Wydawca: Polska Akademia Umiejętności
    Data:
    konferencja 26.05.2017
    Status:
    Published

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