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Nanobodies labeled with alpha emitters as potential radiopharmaceuticals in targeted radioimmunotherapy

2013/09/D/ST4/03791

Keywords

Descriptors

  • ST4_16: Chemia jądrowa i radiacyjna
  • ST5_14: Chemia koordynacyjna
  • ST5_16: Chemia biologiczna

Panel

ST4 – Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution

Instytut Chemii i Techniki Jądrowej

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Marek Pruszyński

Number of co-investigators in the project: 4

Call

SONATA 5 – announced on 2013-03-15

Amount awarded
486 400 PLN
Project start date
2014-02-13
Project end date
2018-02-12
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Dewar kriogeniczny. Cost: 4 800 PLN
  2. Inkubator CO2. Cost: 35 000 PLN
  3. Komora do elektroforezy żelowej. Cost: 4 700 PLN
  4. Komputer. Cost: 4 500 PLN
  5. Wirówka z rotorem horyzontalnym (uchylnym). Cost: 11 000 PLN

Information in the final report

Publication in academic press/journals (3)

  1. Lead(II) complexes with amide-appended tetraazamacrocyclic ligands – Synthesis, structure, characterization and calculation studies

    Authors:
    Krzysztof Łyczko, Monika Łyczko, Marek Pruszyński
    Academic press:
    Polyhedron (year: 2020, volume: 192, pages: 114822), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.poly.2020.114822 – link to the publication

  2. Radiochemical separation of 224Ra from 232U and 228Th sources for 224Ra/212Pb/212Bi generator

    Authors:
    Marek Pruszyński, Rafał Walczak, Magdalena Rodak, Frank Bruchertseifer, Alfred Morgenstern, Aleksander Bilewicz
    Academic press:
    Applied Radiation and Isotopes (year: 2021, volume: 172, pages: 109655), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.apradiso.2021.109655 – link to the publication

  3. Evaluation of an Anti-HER2 Nanobody Labeled with 225Ac for Targeted α‑Particle Therapy of Cancer

    Authors:
    Marek Pruszynski, Matthias D'Huyvetter, Frank Bruchertseifer, Alfred Morgenstern, Tony Lahoutte
    Academic press:
    Molecular Pharmaceutics (year: 2018, volume: 15, pages: 1457-1466), Publisher: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.7b00985 – link to the publication

Articles in post-conference publications (9)

  1. Radionuklidy skandu dla radiofarmaceutyków teranostycznych

    Authors:
    Rafał Walczak, Marek Pruszyński, Ryszard Misiak, Aleksander Bilewicz
    Conference:
    XIV Warszawskie Seminarium Doktorantów Chemików-ChemSession'17 (year: 2017, pages: 178), Publisher: Polskie Towarzystwo Chemiczne, Oficyna Wydawnicza Politechniki Warszawskiej
    Date:
    conference 9,06
    Status:
    Published

  2. Cyclotron production of 47Ca for 47Ca/47Sc generator

    Authors:
    Rafał Walczak, Ryszard Misiak, Marek Pruszyński, Majkowska Agnieszka, Mateusz Sitarz, Jerzy Jastrzębski, Aleksander Bilewicz
    Conference:
    The 23rd International Symposium on Radiopharmaceutical Sciences (ISRS 2019) (year: 2019, pages: S563), Publisher: Wiley
    Date:
    conference 26-31.05
    Status:
    Published

  3. Radiochemical separation of 224Ra from 232U or 228Th sources for 224Ra/212Pb/212Bi generator

    Authors:
    Marek Pruszyński, Edyta Cędrowska, Aleksander Bilewicz, Frank Bruchertseifer, Alfred Morgenstern
    Conference:
    10th International Symposium on Targeted Alpha Therapy (year: 2017, pages: 91), Publisher: Organizatorzy
    Date:
    conference 30.05-01.06
    Status:
    Published

  4. Separacja radionuklidu 224Ra od 232U lub 228Th dla generatora 224Ra/212Pb/212Bi

    Authors:
    Rafał Walczak, Marek Pruszyński, Magdalena Rodak, Edyta Cędrowska, Aleksander Bilewicz, Frank Bruchertseifer, Alfred Morgenstern
    Conference:
    XV Warszawskie Seminarium Doktorantów Chemików - ChemSession'18 (year: 2018, pages: 160), Publisher: Polskie Towarzystwo Chemiczne, Oficyna Wydawnicza Politechniki Warszawskiej
    Date:
    conference 8,06
    Status:
    Published

  5. The therapeutic potential of anti-HER2 2Rs15d nanobody labeled with 225Ac - an in vitro and in vivo evaluation

    Authors:
    Marek Pruszyński, Matthias D'Huyvetter, Magdalena Rodak, Yana Dekempeneer, Edyta Cędrowska, Tony Lahoutte, Frank Bruchertseifer, Alfred Morgenstern
    Conference:
    11th International Symposium on Targeted-Alpha-Therapy (TAT11) (year: 2019, pages: S7), Publisher: Elsevier
    Date:
    conference 01-04.04
    Status:
    Published

  6. Anti HER2 Nanobody Labeled with 225Ac as a Potential Radiopharmaceutical for TRT

    Authors:
    Marek Pruszyński, Edyta Cędrowska, Valery Radchenko, Kevin Dale John, Frank Bruchertseifer, Alfred Morgenstern, Matthias D'Huyvetter, Tony Lahoutte
    Conference:
    Annual Congress of the European Association of Nuclear Medicine (year: 2016, pages: S177), Publisher: Springer
    Date:
    conference 15-19.10
    Status:
    Published

  7. Preclinical evaluation of anti-HER2 2Rs15d nanobody labeled with 225Ac

    Authors:
    Marek Pruszyński, Matthias D'Huyvetter, Edyta Cędrowska, Tony Lahoutte, Frank Bruchertseifer, Alfred Morgenstern
    Conference:
    10th International Symposium on Targeted Alpha Therapy (year: 2017, pages: 36), Publisher: Organizatorzy
    Date:
    conference 30.05-01.06
    Status:
    Published

  8. Przedkliniczne badania nanociała anty-HER2 2Rs15d wyznakowanego 225Ac

    Authors:
    Magdalena Rodak, Marek Pruszyński, Matthias D'Huyvetter, Rafał Walczak, Edyta Cędrowska, Tony Lahoutte, Frank Bruchertseifer, Alfred Morgenstern
    Conference:
    XVI Warszawskie Seminarium Doktorantów Chemików - ChemSession'19 (year: 2019, pages: 145), Publisher: Polskie Towarzystwo Chemiczne, Oficyna Wydawnicza Politechniki Warszawskiej
    Date:
    conference 7,06
    Status:
    Published

  9. Cyklotronowa produkcja 47Ca dla generatora 47Ca/47Sc

    Authors:
    Rafał Walczak, Mateusz Sitarz, Ryszard Misiak, Marek Pruszyński, Agnieszka Majkowska-Pilip, Jerzy Jastrzębski, Ferid Haddad, Aleskander Bilewicz
    Conference:
    XVI Warszawskie Seminarium Doktorantów Chemików - ChemSession'19 (year: 2019, pages: 165), Publisher: Polskie Towarzystwo Chemiczne, Oficyna Wydawnicza Politechniki Warszawskiej
    Date:
    conference 7,06
    Status:
    Published

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