Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Analysis of morphological and molecular signature of invasiveness in breast Ductal Carcinoma in Situ - implications for tumour prognostication

2013/09/B/NZ4/02512

Keywords:

DCIS IDC progression Slug HER2

Descriptors:

  • NZ4_5: Anatomical pathology
  • NZ3_1: Cell biology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Medyczny w Łodzi, Zakład Patologii Katedra Onkologii

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Hanna Romańska-Knight 

Number of co-investigators in the project: 5

Call: OPUS 5 - announced on 2013-03-15

Amount awarded: 695 400 PLN

Project start date (Y-m-d): 2014-02-19

Project end date (Y-m-d): 2018-02-18

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Przystawka fluorescencyjna (82 000 PLN)
  2. Mikroskop odwrócony (18 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  1. Expression of CD151/Tspan24 and integrin alpha3 complex in aid of prognostication of HER2-negative high-grade ductal carcinoma in situ.
    Authors:
    Romanska HM, Potemski P, Kusinska R, Kopczynski J, Sadej R, Kordek R.
    Academic press:
    International Journal of Clinical and Experimantal Pathology (rok: 2015, tom: 8, strony: 9471-9478), Wydawca: e-Century Publishing Corporation
    Status:
    Published
    DOI:
    brak - link to the publication
  2. Fibroblast growth factor signalling induces loss of progesterone receptor in breast cancer cells.
    Authors:
    Piasecka D, Kitowska K, Czaplinska D, Mieczkowski K, Mieszkowska M, Turczyk L, Skladanowski AC, Zaczek AJ, Biernat W, Kordek R, Romanska HM, Sadej R
    Academic press:
    Oncotarget (rok: 2016, tom: 7, strony: 86011-86025), Wydawca: Impact Journals, LLC
    Status:
    Published
    DOI:
    10.18632/oncotarget.13322 - link to the publication
  3. FGFR2-driven signaling counteracts tamoxifen effect on ERalpha-positive breast cancer cells
    Authors:
    Lukasz Turczyk, Kamila Kitowska, Magdalena Mieszkowska, Kamil Mieczkowski, Dominika Czaplinska, Dominika Piasecka, Radzisław Kordek, Andrzej C. Skladanowski, Piotr Potemski, Hanna M. Romanska, Rafal Sadej
    Academic press:
    Neoplasia (rok: 2017, tom: 19, strony: 791-804), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neo.2017.07.006 - link to the publication
  4. Interactions between FGFR2 and RSK2-implications for breast cancer prognosis.
    Authors:
    Czaplinska D, Mieczkowski K, Supernat A, Skladanowski AC, Kordek R, Biernat W, Zaczek AJ, Romanska HM, Sadej R
    Academic press:
    Tumour Biology (rok: 2016, tom: 37, strony: 13721-13731), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s13277-016-5266-9 - link to the publication
  5. Phosphorylation of RSK2 at Tyr529 by FGFR2-p38 enhances human mammary epithelial cells migration.
    Authors:
    Czaplinska D, Turczyk L, Grudowska A, Mieszkowska M, Lipinska AD, Skladanowski AC, Zaczek AJ, Romanska HM, Sadej R
    Academic press:
    Biochemica et Biophysica Acta (BBA) (rok: 2014, tom: 1843, strony: 2461-2470), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamcr.2014.06.022 - link to the publication
  6. Lack of CD151/integrin α3β1 complex is predictive of poor outcome in node-negative lobular breast carcinoma: opposing roles of CD151 in invasive lobular and ductal breast cancers.
    Authors:
    Romanska H, Potemski P, Krakowska M, Mieszkowska M, Chaudhri S, Kordek R, Kubiak R, Speirs V, Hanby V, Sadej R, Berditchevski F
    Academic press:
    British Journal of Cancer (rok: 2015, tom: 113, strony: 1350-7), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/bjc.2015.344. - link to the publication

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