Applications of vibrational spectroscopy and femtosecond spectroscopy in oncological diagnostics of human breast.

2012/07/B/ST4/01588

Keywords

Descriptors

  • ST4_3: Metody spektroskopowe i spektrometryczne
  • ST4_8: Metody instrumentalne w chemii
  • ST4_13: Chemia fizyczna układów biologicznych

Panel

ST4 – Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution

Politechnika Łódzka, Wydział Chemiczny

Voivodeship: łódzkie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Halina Abramczyk

Number of co-investigators in the project: 8

Call

OPUS 4 – announced on 2012-09-15

Amount awarded
840 000 PLN
Project start date
2013-07-22
Project end date
2016-07-21
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Laser pompujący wzmacniacz w femtosekundowym układzie laserowym.. Cost: 470 000 PLN

Information in the final report

Publication in academic press/journals (9)

  1. Oncologic photodynamic diagnosis and therapy: confocal Raman/fluorescence imaging of metal phthalocyanines in human breast cancer tissue in vitro

    Authors:
    Halina Abramczyk, Beata Brozek-Pluska, Jakub Surmacki, Jacek Musial and Radzislaw Kordek
    Academic press:
    Analyst (year: 2014, volume: 139, pages: 5547-5559), Publisher: Royal Chemical Society
    Status:
    Published
    DOI:
    10.1039/C4AN00966E – link to the publication
  2. New look inside human breast ducts with Raman imaging. Raman candidates as diagnostic markers for breast cancer prognosis: Mammaglobin, palmitic acid and sphingomyelin

    Authors:
    Halina Abramczyk, Beata Brozek-Pluska
    Academic press:
    Analytica Chimica Acta (year: 2016, volume: 909, pages: 91-100), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.aca.2015.12.038 – link to the publication
  3. Epigenetic changes in cancer by Raman imaging, fluorescence imaging, AFM and scanning near-field optical (SNOM). Acetylation in normal and human cancer breast cells MCF10A, MCF7 and MDA-MB-231

    Authors:
    H. Abramczyk, J. Surmacki, M. Kopec, A.K. Olejnik, A. Kaufman-Szymczyk, K. Fabianowska-Majewska
    Academic press:
    Analyst (year: 2016, volume: 141(19), pages: 5646-58), Publisher: RCS-Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C6AN00859C – link to the publication
  4. Raman microspectroscopy of Hematoporphyrins. Imaging of the noncancerous and the cancerous human breast tissues with photosensitizers.

    Authors:
    Brozek-Pluska B, Kopec M
    Academic press:
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (year: 2016, volume: 169, pages: 182–191), Publisher: Elsvier
    Status:
    Published
    DOI:
    10.1016/j.saa.2016.06.038 – link to the publication
  5. The lipid-reactive oxygen species phenotype of breast cancer. Raman spectroscopy and mapping, PCA and PLSDA for invasive ductal carcinoma and invasive lobular carcinoma. Molecular tumorigenic mechanisms beyond Warburg effect

    Authors:
    Jakub Surmacki, Beata Brozek-Pluska, Radzislaw Kordek and Halina Abramczyk
    Academic press:
    Analyst (year: 2015, volume: 140, pages: 2121-2133), Publisher: Royal Chemical Society
    Status:
    Published
    DOI:
    10.1039/C4AN01876A – link to the publication
  6. The role of lipid droplets and adipocytes in cancer. Raman imaging of cell cultures: MCF10A, MCF7, and MDA-MB-231 compared to adipocytes in cancerous human breast tissue

    Authors:
    Halina Abramczyk, Jakub Surmacki, Monika Kopeć, Alicja Klaudia Olejnik, Katarzyna Lubecka-Pietruszewska and Krystyna Fabianowska-Majewska
    Academic press:
    Analyst (year: 2015, volume: 140, pages: 2224-2235), Publisher: Royal Chemical Society
    Status:
    Published
    DOI:
    10.1039/C4AN01875C – link to the publication
  7. Raman microspectroscopy of noncancerous and cancerous human breast tissues. Identification and phase transitions of linoleic and oleic acids by Raman low-temperature studies

    Authors:
    Beata Brozek-Pluska, Monika Kopec, Jakub Surmacki and Halina Abramczyk
    Academic press:
    Analyst (year: 2015, volume: 140, pages: 2134-2143), Publisher: Royal Chemical Society
    Status:
    Published
    DOI:
    10.1039/C4AN01877J – link to the publication
  8. The cellular environment of cancerous human tissue. Interfacial and dangling water as a hydration fingerprint

    Authors:
    Abramczyk H, Brozek-Pluska B, Krzesniak M, Kopec M, Morawiec-Sztandera A.
    Academic press:
    Spectrochim Acta A Mol Biomol Spectrosc (year: 2014, volume: 129, pages: 609-23), Publisher: Elsevier B.V
    Status:
    Published
    DOI:
    10.1016/j.saa.2014.03.103 – link to the publication
  9. Photostability of Biological Systems - Femtosecond Dynamics of Zinc Tetrasulfonated Phthalocyanine at Cancerous and Noncancerous Human Breast Tissues

    Authors:
    H. Abramczyk, B. Brozek-Pluska, M. Tondusson, E. Freysz
    Academic press:
    Journal of Photochemistry & Photobiology, A: Chemistry (year: 2017, volume: 332, pages: 46319), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jphotochem.2016.08.012 – link to the publication

Articles in post-conference publications (15)

  1. Obrazowanie Ramana i technika SERS w analizie tkanek i linii komórkowych ludzkiego gruczołu piersiowego

    Authors:
    B. Brożek-Płuska, J. Surmacki, M. Kopeć, H. Abramczyk
    Conference:
    Seminarium Na granicy powierzchni i światła: Adsorpcja i spektroskopia SERS (year: 2015, pages: 18-19), Publisher: UJ, Polska
    Date:
    conference 02-03.07
    Status:
    Published
  2. Hope and Innovative Cancer Diagnostics by Raman,

    Authors:
    H. Abramczyk, M. Kopeć, B. Brożek-Płuska
    Conference:
    12th confocal Raman Imaging Symposium, (year: 2015, pages: 1), Publisher: WITec GmbH, Germany
    Date:
    conference 28-30.09
    Status:
    Published
  3. Obrazowanie ramanowskie w mikroskali-od pojedynczej komórki do tkanki,

    Authors:
    Monika Kopeć, Beata Brożek-Płuska, Jakub Surmacki, Halina Abramczyk
    Conference:
    II Poznańskie Sympozjum młodych Naukowców. Nowe Oblicze Nauk Przyrodniczych (year: 2015, pages: 103), Publisher: Wydział Chemii UAM
    Date:
    conference 14,11
    Status:
    Published
  4. Zastosowanie obrazowania ramanowskiego w analizie układów biologicznych.

    Authors:
    Monika Kopeć, Halina Abramczyk
    Conference:
    Mała Wielka Nauka, mikro, nano i co dalej? (year: 2014, pages: SO1_P_42), Publisher: Politechnika Łódzka
    Date:
    conference 4-5.12
    Status:
    Published
    DOI:
    link to the publication
  5. Wielonienasycone kwasy tłuszczowe jako czynniki modyfikujące procesy nowotworowe

    Authors:
    Monika Kopeć, Beata Brożek-Płuska, Jakub Surmacki, Halina Abramczyk
    Conference:
    III Łódzkie Sympozjum Doktorantów Chemii (year: 2015, pages: 59), Publisher: Wydział Chemii UŁ
    Date:
    conference 27-28.04
    Status:
    Published
  6. The application of Raman imaging in the analysis of biological systems, ,,

    Authors:
    Monika Kopeć, Halina Abramczyk
    Conference:
    V Wyjazdowa Sesja Naukowa Doktorantów Politechniki Łódzkiej (year: 2015, pages: P-17), Publisher: Wydział Chemiczny PŁ
    Date:
    conference 9-12.04
    Status:
    Published
  7. Raman spectroscopy and imaging of human breast tissues and cel lines-optical imaging technologies in medical applications

    Authors:
    B. Brożek-Płuska, J. Surmacki, M. Kopeć, J. Musiał, R. Kordek, H. Abramczyk,
    Conference:
    Advanced Vibrational Spectroscopy for Biomedical Applications (year: 2016, pages: 1), Publisher: St Catherine's College, Cambridge, UK
    Date:
    conference 21-23. 03.2016 r
    Status:
    Published
  8. Hope and Innovative Cancer Diagnostic by Raman Imaging,

    Authors:
    M. Kopeć, H. Abramczyk
    Conference:
    VI Wyjazdowa Sesja Naukowa Doktorantów Politechniki Łódzkiej (year: 2016, pages: 66), Publisher: Wydawnictwa Politechniki Łódzkiej
    Date:
    conference 11-13.04.2016 r, Łódź, Polska
    Status:
    Published
  9. The application of Raman imaging in the analysis of biological systems

    Authors:
    M. Kopeć, B. Brożek-Płuska, J. Surmacki, H. Abramczyk
    Conference:
    EMLG/JMLG Annual Meeting 2016 (year: 2016, pages: brak), Publisher: EMLG/JMLG
    Date:
    conference 11-16.09.2016
    Status:
    Published
  10. Obrazowanie Ramana w analizie układów biologicznych-skala mikro,

    Authors:
    Monika Kopeć, Beata Brożek-Płuska, Halina Abramczyk
    Conference:
    Mała Wielka Nauka, Innowacje idee przyszłości (year: 2015, pages: 81), Publisher: Wydział Chemiczny PŁ
    Date:
    conference 10-11.12
    Status:
    Published
  11. Obrazowanie Ramana w biochemicznych i biomedycznych zastosowaniach na tle innych technik obrazowania,

    Authors:
    A. Korycińska, H. Abramczyk
    Conference:
    V Konferencja Biologii Molekularnej (year: 2016, pages: 46338), Publisher: Uniwersytet Łodzki
    Date:
    conference 7-9.04.2016r
    Status:
    Published
  12. Obrazowanie Ramana ludzkiej tkanki nowotworowej oraz normalnych i nowotworowych kultur komórkowych,

    Authors:
    M. Kopeć, B. Brożek-Płuska, J. Surmacki, H. Abramczyk, A.K. Olejnik, A. Kaufman-Szymczyk, K. Fabianowska-Majewska
    Conference:
    IV Łódzkie Sympozjum Doktorantów Chemii (year: 2016, pages: 28), Publisher: Wydawnictwa Politechniki Łódzkiej
    Date:
    conference 12-13.05.2016 r
    Status:
    Published
  13. Obrazowanie Ramana ludzkiej tkanki nowotworowej oraz nowotworowych i normalnych kultur komórkowych.

    Authors:
    Monika Kopeć, Jakub Surmacki, Halina Abramczyk
    Conference:
    II Łódzkie Sympozjum Doktorantów Chemii (year: 2014, pages: 100), Publisher: Dział Wydawnictw Naukowo-Dydaktycznych Politechniki Łódzkiej
    Date:
    conference 7-8.05
    Status:
    Published
    DOI:
    link to the publication
  14. Confocal Raman microscpectroscopy of human tissues and human cell lines.

    Authors:
    B. Brożek-Płuska, J. Surmacki, M. Kopeć, J. Musiał, R. Kordek, I. Niedźwiecka, A. Morawiec-Sztandera, H. Abramczyk
    Conference:
    SPEC 2014, Shedding New Light on Disease (year: 2014, pages: 13), Publisher: Faculty of Chemistry, Jagiellonian University, Krakow, Poland
    Date:
    conference 17-22.08
    Status:
    Published
    DOI:
    link to the publication
  15. Study of clofarabine induced effects in breast cancer cells MCF-7 by means of confocal Raman microspectroscopy.

    Authors:
    J. Surmacki, K. Lubecka-Pietruszewska, K. Fabianowska-Majewska, H. Abramczyk
    Conference:
    SPEC 2014, Shedding New Light on Disease (year: 2014, pages: P166), Publisher: Faculty of Chemistry, Jagiellonian University, Krakow, Poland
    Date:
    conference 17-22.08
    Status:
    Published
    DOI:
    link to the publication

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Graphic design and implementation: Jakub Piotrowski