Identification of a new biomarkers of pathophysiological status based on metabolomics and bioinformatically integrated systeomic approach

2012/07/E/NZ7/04411

Keywords

Descriptors

  • NZ2_4: Metabolomika
  • NZ2_7: Bioinformatyka
  • NZ7_14: Farmacja, farmakoterapia, farmakologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

Voivodeship: pomorskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Michał Jan Markuszewski

Number of co-investigators in the project: 6

Call

SONATA BIS 2 – announced on 2012-09-15

Amount awarded
1 498 900 PLN
Project start date
2013-07-05
Project end date
2020-07-04
Project duration
84 months (the same as in the proposal)
Project status
Project settled

Information in the final report

Publication in academic press/journals (15)

  1. Bayesian multilevel model of micro RNA levels in ovarian-cancer and healthy subjects

    Authors:
    Wiczling, P., Daghir-Wojtkowiak, E., Kaliszan, R., Markuszewski, M.J., Limon, J., Koczkowska, M., Stukan, M., Kuźniacka, A., Ratajska, M.
    Academic press:
    PLoS ONE (year: 2019, volume: 14, pages: 46039), Publisher: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0221764 – link to the publication
  2. New plasma preparation approach to enrich metabolome coverage in untargeted metabolomics: plasma protein bound hydrophobic metabolite release with proteinase K

    Authors:
    Renata Wawrzyniak, Anna Kosnowska, Szymon Macioszek, Rafał Bartoszewski, Michał Jan Markuszewski
    Academic press:
    Scientific Reports (year: 2018, volume: 8, pages: 46032), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-018-27983-0 – link to the publication
  3. Determination of urinary pterins by capillary electrophoresis coupled with LED-induced fluorescence detector

    Authors:
    Grochocki, W., Buszewska-Forajta, M., Macioszek, S., Markuszewski, M.J.
    Academic press:
    Molecules (year: 2019, volume: 24, pages: 1166), Publisher: MDPI AG
    Status:
    Published
    DOI:
    10.3390/molecules24061166 – link to the publication
  4. Design of Experiments in metabolomics-related studies: An overview

    Authors:
    Jacyna, J., Kordalewska, M., Markuszewski, M.J.
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (year: 2019, volume: 164, pages: 598-606), Publisher: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.jpba.2018.11.027 – link to the publication
  5. Multiplatform metabolomics provides insight into the molecular basis of chronic kidney disease

    Authors:
    Kordalewska, M., Macioszek, S., Wawrzyniak, R., Sikorska-Wiśniewska, M., Śledziński, T., Chmielewski, M., Mika, A., Markuszewski, M.J.
    Academic press:
    Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences (year: 2019, volume: 1117, pages: 49-57), Publisher: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.jchromb.2019.04.003 – link to the publication
  6. Urinary metabolomic signature of muscle-invasive bladder cancer: A multiplatform approach

    Authors:
    Jacyna, J., Wawrzyniak, R., Balayssac, S., Gilard, V., Malet-Martino, M., Sawicka, A., Kordalewska, M., Nowicki L., Kurek, E., Bulska, E., Patejko, M., Markuszewski, M., Gutknecht, P., Matuszewski, M., Siebert, J., Kaliszan, R., Markuszewski, M.J.
    Academic press:
    Talanta (year: 2019, volume: 202, pages: 572-579), Publisher: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.talanta.2019.05.039 – link to the publication
  7. Volatile organic compounds in gastrointestinal stromal tumour tissue originating from patient-derived xenografts

    Authors:
    Renata Wawrzyniak, AgnieszkaWoźniak, Ye Marshet K Gebreyohannes, Bartosz Dykcik, Patrick Schöffski,Michał J Markuszewski
    Academic press:
    Journal of Breath Research (year: 2017, volume: 11, pages: 37101), Publisher: IOP Publishing
    Status:
    Published
    DOI:
    10.1088/1752-7163/aa6d87 – link to the publication
  8. GC-MS-based untargeted metabolomics of plasma and urine to evaluate metabolic changes in prostate cancer

    Authors:
    Struck-Lewicka W., Wawrzyniak R., Artymowicz M., Kordalewska M., Markuszewski M., Matuszewski M., Gutknecht P., Siebert J., Markuszewski M.J.
    Academic press:
    Journal of Breath Research (year: 2020, volume: 14, pages: 46035), Publisher: IOP Publishing
    Status:
    Published
    DOI:
    10.1088/1752-7163/abaeca – link to the publication
  9. Determination of pterins in urine by HPLC with UV and fluoroscent detection using different types of chromatographic stationary phases (HILIC, RP C8, RP C18)

    Authors:
    Kośliński P., Jarzemski P., Markuszewski M.J., Kaliszan R.
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (year: 2014, volume: 91, pages: 37-45), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pba.2013.12.012 – link to the publication
  10. Analysis of urinary nucleosides as potential cancer markers determined using LC-MS technique

    Authors:
    Struck-Lewicka W., Kaliszan R., Markuszewski M.J.
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (year: 2014, volume: 101, pages: 50-57), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pba.2014.04.022 – link to the publication
  11. Urine metabolic fingerprinting using LC-MS and GC-MS reveals metabolite changes in prostate cancer : a pilot study

    Authors:
    W. Struck-Lewicka, M. Kordalewska, R. Bujak, A. Yumba Mpanga, M. Markuszewski, J. Jacyna, M. Matuszewski, R. Kaliszan, Michał J. Markuszewski
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (year: 2015, volume: 111, pages: 351-361), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jpba.2014.12.026 – link to the publication
  12. Metabolomics in cardiovascular diseases

    Authors:
    M. Kordalewska, Michał J. Markuszewski
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (year: 2015, volume: 113, pages: 121-136), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jpba.2015.04.021 – link to the publication
  13. Metabolomic Signature of Early Vascular Aging (EVA) in Hypertension

    Authors:
    Polonis K., Wawrzyniak R., Daghir-Wojtkowiak E., Szyndler A., Chrostowska M., Melander O., Hoffmann M., Kordalewska M., Raczak-Gutknecht J., Bartosińska E., Kaliszan R.,Narkiewicz K., Markuszewski M.J.
    Academic press:
    Frontiers in Molecular Biosciences (year: 2020, volume: 7, pages: 46033), Publisher: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmolb.2020.00012 – link to the publication
  14. Multilevel pharmacokinetics-driven modeling of metabolomics data

    Authors:
    Emilia Daghir‑Wojtkowiak, Paweł Wiczling, Małgorzata Waszczuk‑Jankowska, Roman Kaliszan, Michał Jan Markuszewski
    Academic press:
    Metabolomics (year: 2017, volume: 13, pages: 31), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s11306-017-1164-4 – link to the publication
  15. Untargeted metabolomics provides insight into mechanisms underlying resistant hypertension

    Authors:
    Renata Bujak, Arlette Yumba- Mpanga, Wiktoria Struck-Lewicka, Marta Kordalewska, Katarzyna Polonis, Małgorzata Patejko, Monika Mironiuk, Anna Szyndler, Marzena Chrostowska, Michał Hoffmann, Ryszard T. Smoleński, Roman Kaliszan, Krzysztof Narkiewicz, Michał J. Markuszewski
    Academic press:
    Current Medicinal Chemistry (year: 2019, volume: 26, pages: 232-243), Publisher: Bentham Science Publ.
    Status:
    Published
    DOI:
    10.2174/0929867324666171006122656 – link to the publication

Book publications / chapters in book publications (1)

  1. Urinary Nucleosides and Deoxynucleosides

    Authors:
    Małgorzata Patejko, Wiktoria Struck-Lewicka, Danuta Siluk, Małgorzata Waszczuk-Jankowska, Michał J. Markuszewski
    Book:
    Advances in Clinical Chemistry (year: 2018, volume: 83, pages: 18629), Publisher: Academic Press
    Status:
    Published
    DOI:
    link to the publication

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Graphic design and implementation: Jakub Piotrowski