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Information on the principal investigator and host institution

Information of the project and the call

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Identification of a new biomarkers of pathophysiological status based on metabolomics and bioinformatically integrated systeomic approach

2012/07/E/NZ7/04411

Keywords:

metabolomics macromolecules biomarkers bioinformatics LC-TOF LC-MS/ MS GC-MS CE-TOF cardiovascular diseases cancer diseases

Descriptors:

  • NZ2_4: Metabolomics
  • NZ2_7: Bioinformatics
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Michał Markuszewski 

Number of co-investigators in the project: 6

Call: SONATA BIS 2 - announced on 2012-09-15

Amount awarded: 1 498 900 PLN

Project start date (Y-m-d): 2013-07-05

Project end date (Y-m-d): 2020-07-04

Project duration:: 84 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (15)
  • Book publications / chapters in book publications (1)
  1. Determination of pterins in urine by HPLC with UV and fluoroscent detection using different types of chromatographic stationary phases (HILIC, RP C8, RP C18)
    Authors:
    Kośliński P., Jarzemski P., Markuszewski M.J., Kaliszan R.
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (rok: 2014, tom: 91, strony: 37-45), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pba.2013.12.012 - link to the publication
  2. New plasma preparation approach to enrich metabolome coverage in untargeted metabolomics: plasma protein bound hydrophobic metabolite release with proteinase K
    Authors:
    Renata Wawrzyniak, Anna Kosnowska, Szymon Macioszek, Rafał Bartoszewski, Michał Jan Markuszewski
    Academic press:
    Scientific Reports (rok: 2018, tom: 8, strony: 45301), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-018-27983-0 - link to the publication
  3. Volatile organic compounds in gastrointestinal stromal tumour tissue originating from patient-derived xenografts
    Authors:
    Renata Wawrzyniak, AgnieszkaWoźniak, Ye Marshet K Gebreyohannes, Bartosz Dykcik, Patrick Schöffski,Michał J Markuszewski
    Academic press:
    Journal of Breath Research (rok: 2017, tom: 11, strony: 37101), Wydawca: IOP Publishing
    Status:
    Published
    DOI:
    10.1088/1752-7163/aa6d87 - link to the publication
  4. Urine metabolic fingerprinting using LC-MS and GC-MS reveals metabolite changes in prostate cancer : a pilot study
    Authors:
    W. Struck-Lewicka, M. Kordalewska, R. Bujak, A. Yumba Mpanga, M. Markuszewski, J. Jacyna, M. Matuszewski, R. Kaliszan, Michał J. Markuszewski
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (rok: 2015, tom: 111, strony: 351-361), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jpba.2014.12.026 - link to the publication
  5. Bayesian multilevel model of micro RNA levels in ovarian-cancer and healthy subjects
    Authors:
    Wiczling, P., Daghir-Wojtkowiak, E., Kaliszan, R., Markuszewski, M.J., Limon, J., Koczkowska, M., Stukan, M., Kuźniacka, A., Ratajska, M.
    Academic press:
    PLoS ONE (rok: 2019, tom: 14, strony: 45308), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0221764 - link to the publication
  6. GC-MS-based untargeted metabolomics of plasma and urine to evaluate metabolic changes in prostate cancer
    Authors:
    Struck-Lewicka W., Wawrzyniak R., Artymowicz M., Kordalewska M., Markuszewski M., Matuszewski M., Gutknecht P., Siebert J., Markuszewski M.J.
    Academic press:
    Journal of Breath Research (rok: 2020, tom: 14, strony: 45304), Wydawca: IOP Publishing
    Status:
    Published
    DOI:
    10.1088/1752-7163/abaeca - link to the publication
  7. Multiplatform metabolomics provides insight into the molecular basis of chronic kidney disease
    Authors:
    Kordalewska, M., Macioszek, S., Wawrzyniak, R., Sikorska-Wiśniewska, M., Śledziński, T., Chmielewski, M., Mika, A., Markuszewski, M.J.
    Academic press:
    Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences (rok: 2019, tom: 1117, strony: 49-57), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.jchromb.2019.04.003 - link to the publication
  8. Analysis of urinary nucleosides as potential cancer markers determined using LC-MS technique
    Authors:
    Struck-Lewicka W., Kaliszan R., Markuszewski M.J.
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (rok: 2014, tom: 101, strony: 50-57), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pba.2014.04.022 - link to the publication
  9. Metabolomic Signature of Early Vascular Aging (EVA) in Hypertension
    Authors:
    Polonis K., Wawrzyniak R., Daghir-Wojtkowiak E., Szyndler A., Chrostowska M., Melander O., Hoffmann M., Kordalewska M., Raczak-Gutknecht J., Bartosińska E., Kaliszan R.,Narkiewicz K., Markuszewski M.J.
    Academic press:
    Frontiers in Molecular Biosciences (rok: 2020, tom: 7, strony: 45302), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmolb.2020.00012 - link to the publication
  10. Multilevel pharmacokinetics-driven modeling of metabolomics data
    Authors:
    Emilia Daghir‑Wojtkowiak, Paweł Wiczling, Małgorzata Waszczuk‑Jankowska, Roman Kaliszan, Michał Jan Markuszewski
    Academic press:
    Metabolomics (rok: 2017, tom: 13, strony: 31), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11306-017-1164-4 - link to the publication
  11. Untargeted metabolomics provides insight into mechanisms underlying resistant hypertension
    Authors:
    Renata Bujak, Arlette Yumba- Mpanga, Wiktoria Struck-Lewicka, Marta Kordalewska, Katarzyna Polonis, Małgorzata Patejko, Monika Mironiuk, Anna Szyndler, Marzena Chrostowska, Michał Hoffmann, Ryszard T. Smoleński, Roman Kaliszan, Krzysztof Narkiewicz, Michał J. Markuszewski
    Academic press:
    Current Medicinal Chemistry (rok: 2019, tom: 26, strony: 232-243), Wydawca: Bentham Science Publ.
    Status:
    Published
    DOI:
    10.2174/0929867324666171006122656 - link to the publication
  12. Design of Experiments in metabolomics-related studies: An overview
    Authors:
    Jacyna, J., Kordalewska, M., Markuszewski, M.J.
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (rok: 2019, tom: 164, strony: 598-606), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.jpba.2018.11.027 - link to the publication
  13. Determination of urinary pterins by capillary electrophoresis coupled with LED-induced fluorescence detector
    Authors:
    Grochocki, W., Buszewska-Forajta, M., Macioszek, S., Markuszewski, M.J.
    Academic press:
    Molecules (rok: 2019, tom: 24, strony: 1166), Wydawca: MDPI AG
    Status:
    Published
    DOI:
    10.3390/molecules24061166 - link to the publication
  14. Metabolomics in cardiovascular diseases
    Authors:
    M. Kordalewska, Michał J. Markuszewski
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (rok: 2015, tom: 113, strony: 121-136), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jpba.2015.04.021 - link to the publication
  15. Urinary metabolomic signature of muscle-invasive bladder cancer: A multiplatform approach
    Authors:
    Jacyna, J., Wawrzyniak, R., Balayssac, S., Gilard, V., Malet-Martino, M., Sawicka, A., Kordalewska, M., Nowicki L., Kurek, E., Bulska, E., Patejko, M., Markuszewski, M., Gutknecht, P., Matuszewski, M., Siebert, J., Kaliszan, R., Markuszewski, M.J.
    Academic press:
    Talanta (rok: 2019, tom: 202, strony: 572-579), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.talanta.2019.05.039 - link to the publication
  1. Urinary Nucleosides and Deoxynucleosides
    Authors:
    Małgorzata Patejko, Wiktoria Struck-Lewicka, Danuta Siluk, Małgorzata Waszczuk-Jankowska, Michał J. Markuszewski
    Book:
    Advances in Clinical Chemistry (rok: 2018, tom: 83, strony: 18629), Wydawca: Academic Press
    Status:
    Published
    DOI:
    link to the publication

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