Molecular mechanisms of cell death evoked by a monoclonal antibody binding to GD2 ganglioside expressed on human neuroblastoma cells. A role of aurora A kinase.
2012/07/B/NZ1/02808
Keywords
Descriptors
- NZ1_1: Biologia molekularna
Panel
NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution
Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii
Voivodeship: małopolskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 6
Call
OPUS 4 – announced on 2012-09-15
- Amount awarded
- 509 600 PLN
- Project start date
- 2013-07-10
- Project end date
- 2016-11-09
- Project duration
- 40 months (the same as in the proposal)
- Project status
- Project settled
Equipment purchased [PL]
- Inkubator CO2 do hodowli komórkowych. Cost: 43 000 PLN
- Pompa perystaltyczna.
- Wytrząsarka platformowa z termostatem. Cost: 22 000 PLN
Information in the final report
Publication in academic press/journals (5)
-
Downregulation of the PHLDA1 gene in IMR-32 neuroblastoma cells increases phosphorylation of aurora A and affects proteins involved in apoptosis and autophagy pathways
- Authors:
- Małgorzata Durbas, Irena Horwacik, Elżbieta Boratyn, Hanna Rokita
- Academic press:
- Int J Oncol (year: 2016, volume: 49, pages: 823-837), Publisher: Spandidos Publ.
- Status:
- Published
- DOI:
- 10.3892/ijo.2016.3572 – link to the publication
-
Modulation of interactions of neuroblastoma cell lines with extracellular matrix proteins affects their sensitivity to treatment with anti-GD2 ganglioside antibody 14G2a
- Authors:
- Irena Horwacik, Hanna Rokita
- Academic press:
- Int J Oncol (year: 2017, volume: 50, pages: 1899-1914), Publisher: Spandidos Publ.
- Status:
- Published
- DOI:
- 10.3892/ijo.2017.3959 – link to the publication
-
Targeting of tumor-associated gangliosides with antibodies affects signaling pathways and leads to cell death including apoptosis
- Authors:
- Irena Horwacik, Hanna Rokita
- Academic press:
- Apoptosis (year: 2015, volume: 20, pages: 46032), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s10495-015-1103-7 – link to the publication
-
GD2 ganglioside specific antibody treatment down-regulates PI3K/Akt/mTOR signaling network in human neuroblastoma cell lines
- Authors:
- Małgorzata Durbas, Irena Horwacik, Elżbieta Boratyn, Elżbieta Karnas, Hanna Rokita
- Academic press:
- Int J Oncol (year: 2015, volume: 47, pages: 1143-1159), Publisher: Spandidos Publ.
- Status:
- Published
-
Analysis of genes involved in response to doxorubicin and a GD2 ganglioside-specific 14G2a monoclonal antibody in IMR-32 human neuroblastoma cells.
- Authors:
- Horwacik I, Durbas M, Boratyn E, Sawicka A, Węgrzyn P, Krzanik S, Górka A, Drożniak J, Augustyniak E, Kowalczyk A, Rokita H
- Academic press:
- Acta Biochimica Polonica (year: 2015, volume: 62, pages: 423-433), Publisher: Polish Biochemical Society & Polish Academy of Sciences
- Status:
- Published