Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Molecular mechanisms of cell death evoked by a monoclonal antibody binding to GD2 ganglioside expressed on human neuroblastoma cells. A role of aurora A kinase.

2012/07/B/NZ1/02808

Keywords:

cancer neuroblastoma GD2 ganglioside-recognizing antibodies intracellular signaling

Descriptors:

  • NZ1_1: Molecular biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

UNIWERSYTET JAGIELLOŃSKI, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Hanna Rokita 

Number of co-investigators in the project: 6

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 509 600 PLN

Project start date (Y-m-d): 2013-07-10

Project end date (Y-m-d): 2016-11-09

Project duration:: 40 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Inkubator CO2 do hodowli komórkowych (43 000 PLN)
  2. Wytrząsarka platformowa z termostatem (22 000 PLN)
  3. Pompa perystaltyczna.

Information in the final report

  • Publication in academic press/journals (5)
  1. Downregulation of the PHLDA1 gene in IMR-32 neuroblastoma cells increases phosphorylation of aurora A and affects proteins involved in apoptosis and autophagy pathways
    Authors:
    Małgorzata Durbas, Irena Horwacik, Elżbieta Boratyn, Hanna Rokita
    Academic press:
    Int J Oncol (rok: 2016, tom: 49, strony: 823-837), Wydawca: Spandidos Publ.
    Status:
    Published
    DOI:
    10.3892/ijo.2016.3572 - link to the publication
  2. GD2 ganglioside specific antibody treatment down-regulates PI3K/Akt/mTOR signaling network in human neuroblastoma cell lines
    Authors:
    Małgorzata Durbas, Irena Horwacik, Elżbieta Boratyn, Elżbieta Karnas, Hanna Rokita
    Academic press:
    Int J Oncol (rok: 2015, tom: 47, strony: 1143-1159), Wydawca: Spandidos Publ.
    Status:
    Published
    DOI:
    brak - link to the publication
  3. Analysis of genes involved in response to doxorubicin and a GD2 ganglioside-specific 14G2a monoclonal antibody in IMR-32 human neuroblastoma cells.
    Authors:
    Horwacik I, Durbas M, Boratyn E, Sawicka A, Węgrzyn P, Krzanik S, Górka A, Drożniak J, Augustyniak E, Kowalczyk A, Rokita H
    Academic press:
    Acta Biochimica Polonica (rok: 2015, tom: 62, strony: 423-433), Wydawca: Polish Biochemical Society & Polish Academy of Sciences
    Status:
    Published
    DOI:
    brak - link to the publication
  4. Modulation of interactions of neuroblastoma cell lines with extracellular matrix proteins affects their sensitivity to treatment with anti-GD2 ganglioside antibody 14G2a
    Authors:
    Irena Horwacik, Hanna Rokita
    Academic press:
    Int J Oncol (rok: 2017, tom: 50, strony: 1899-1914), Wydawca: Spandidos Publ.
    Status:
    Published
    DOI:
    10.3892/ijo.2017.3959 - link to the publication
  5. Targeting of tumor-associated gangliosides with antibodies affects signaling pathways and leads to cell death including apoptosis
    Authors:
    Irena Horwacik, Hanna Rokita
    Academic press:
    Apoptosis (rok: 2015, tom: 20, strony: 45301), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10495-015-1103-7 - link to the publication

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