Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Studies on generation conditions and identification of reactive intermediates from model antitumor acridinone derivatives.

2012/07/D/NZ7/03395

Keywords:

antitumor agents reactive intermediates (IRs) electrochemical metabolism simulation electrosynthesis EC/LC/MS nucleophilic trapping agents metabolite structures detoxification metabolism glutathione S-transferases (GSTs) sulfotransferases (SULTs)

Descriptors:

  • NZ1_2: Biochemistry
  • NZ7_15: Toxicology
  • ST4_9: Biological chemistry

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Politechnika Gdańska, Wydział Chemiczny

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Agnieszka Potęga 

Number of co-investigators in the project: 4

Call: SONATA 4 - announced on 2012-09-15

Amount awarded: 358 110 PLN

Project start date (Y-m-d): 2013-07-02

Project end date (Y-m-d): 2016-07-01

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. ROXY™ EC system (p/n 210.0070) (Antec, Woburn, MA, USA) (130 000 PLN)
  2. Elektroporator wraz z niezbędnym wyposażeniem (kuwety, bufory itp.) (BTX, Harvard Apparatus, Inc., Holliston, MA, USA) (40 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (6)
  1. Mechanism-based inactivation of human cytochrome P450 1A2 and 3A4 isoenzymes by anti-tumour triazoloacridinone C-1305
    Authors:
    Agnieszka Potęga, Barbara Fedejko-Kap, Zofia Mazerska
    Academic press:
    Xenobiotica (rok: 2016, tom: Early Online, strony: 45301), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.3109/00498254.2016.1147623 - link to the publication
  2. Imidazoacridinone antitumor agent C-1311 as a selective mechanism-based inactivator of human cytochrome P450 1A2 and 3A4 isoenzymes.
    Authors:
    Agnieszka Potęga, Barbara Fedejko-Kap, Zofia Mazerska
    Academic press:
    Pharmacological Reports (rok: 2016, tom: 68, strony: 663 - 670), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2016.02.003 - link to the publication
  1. C-1311 and C-1305-mediated mechanism based inhibition of CYP1A2 and CYP34A – insight into electrochemical identification and characterization of reactive metabolites.
    Authors:
    Agnieszka Potęga, Barbara Fedejko-Kap, Zofia Mazerska
    Conference:
    20th North American ISSX Meeting (rok: 2015, ), Wydawca: International Society for the Study of Xenobiotics
    Data:
    konferencja 18 - 22.10.2015
    Status:
    Published
    DOI:
    link to the publication
  2. Electrochemical identification of the novel glutathione conjugates of antitumor-active acridinones, 2-hydroxacridinone and C-1305
    Authors:
    Agnieszka Potęga, Dorota Garwolińska, Anna Maria Nowicka, Michał Fau, Zofia Mazerska
    Conference:
    2nd Congress of Polish Biochemistry, Cell Biology, Biotechnology and Bioinformatics (rok: 2016, ), Wydawca: Acta Biochim Pol, Abstracts of the Bio 2016 Congress
    Data:
    konferencja 13 - 16.09.2016
    Status:
    Published
  3. Metabolizm leków – badania enzymatyczne vs. symulacja elektrochemiczna./Drug metabolism – enzymatic studies vs. electrochemical simulation.
    Authors:
    Agnieszka Potęga, Zofia Mazerska
    Conference:
    III Sympozjum "Szkoła Chemii Medycznej" (rok: 2017, ), Wydawca: Polskie Towarzystwo Farmaceutyczne
    Data:
    konferencja 06 - 08.09.2017
    Status:
    Published
  4. On-line electrochemistry-mass spectrometry (EC/MS) – A powerful tool for the prediction of drug oxidative metabolism reactions and their molecular mechanism.
    Authors:
    Agnieszka Potęga, Kamila Wilczewska, Zofia Mazerska
    Conference:
    13th European ISSX Meeting (rok: 2015, ), Wydawca: International Societ for the Study of Xenobiotics
    Data:
    konferencja 20 - 25.06.2015
    Status:
    Published
    DOI:
    link to the publication
  5. Effects of antitumor-active acridinones, C-1311 and C-1305, on liver cytosolic glutathione S-transferase activity.
    Authors:
    Agnieszka Potęga, Anna Nowak, Natalia Daca, Monika Pawłowska, Zofia Mazerska
    Conference:
    VIII Konwersatorium Chemii Medycznej (rok: 2016, ), Wydawca: Polskie Towarzystwo Chemii Medycznej
    Data:
    konferencja 15 - 17.09.2016
    Status:
    Published
  6. Electrochemical simulation of enzymatic transformations studied for the selected antitumor acridine derivatives
    Authors:
    Agnieszka Potęga, Weronika Hewelt-Belka, Olga Siewruk, Katarzyna Zapała, Zofia Mazerska
    Conference:
    VI Konwersatorium Chemii Medycznej (rok: 2014, ), Wydawca: Polskie Towarzystwo Chemii Medycznej
    Data:
    konferencja 18 - 20.09.2014
    Status:
    Published

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