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Studies on generation conditions and identification of reactive intermediates from model antitumor acridinone derivatives.

2012/07/D/NZ7/03395

Keywords

Descriptors

  • NZ1_2: Biochemia
  • NZ7_15: Toksykologia
  • ST4_9: Elektrochemia, elektrodializa, chemia w mikrostrumieniach

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Politechnika Gdańska, Wydział Chemiczny

Voivodeship: pomorskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Agnieszka Potęga

Number of co-investigators in the project: 4

Call

SONATA 4 – announced on 2012-09-15

Amount awarded
358 110 PLN
Project start date
2013-07-02
Project end date
2016-07-01
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Elektroporator wraz z niezbędnym wyposażeniem (kuwety, bufory itp.) (BTX, Harvard Apparatus, Inc., Holliston, MA, USA). Cost: 40 000 PLN
  2. ROXY™ EC system (p/n 210.0070) (Antec, Woburn, MA, USA). Cost: 130 000 PLN

Information in the final report

Publication in academic press/journals (2)

  1. Mechanism-based inactivation of human cytochrome P450 1A2 and 3A4 isoenzymes by anti-tumour triazoloacridinone C-1305

    Authors:
    Agnieszka Potęga, Barbara Fedejko-Kap, Zofia Mazerska
    Academic press:
    Xenobiotica (year: 2016, volume: Early Online, pages: 46032), Publisher: Taylor & Francis
    Status:
    Published
    DOI:
    10.3109/00498254.2016.1147623 – link to the publication

  2. Imidazoacridinone antitumor agent C-1311 as a selective mechanism-based inactivator of human cytochrome P450 1A2 and 3A4 isoenzymes.

    Authors:
    Agnieszka Potęga, Barbara Fedejko-Kap, Zofia Mazerska
    Academic press:
    Pharmacological Reports (year: 2016, volume: 68, pages: 663 - 670), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2016.02.003 – link to the publication

Articles in post-conference publications (6)

  1. Electrochemical identification of the novel glutathione conjugates of antitumor-active acridinones, 2-hydroxacridinone and C-1305

    Authors:
    Agnieszka Potęga, Dorota Garwolińska, Anna Maria Nowicka, Michał Fau, Zofia Mazerska
    Conference:
    2nd Congress of Polish Biochemistry, Cell Biology, Biotechnology and Bioinformatics (year: 2016, pages: 97 (P12.5)), Publisher: Acta Biochim Pol, Abstracts of the Bio 2016 Congress
    Date:
    conference 13 - 16.09.2016
    Status:
    Published

  2. Effects of antitumor-active acridinones, C-1311 and C-1305, on liver cytosolic glutathione S-transferase activity.

    Authors:
    Agnieszka Potęga, Anna Nowak, Natalia Daca, Monika Pawłowska, Zofia Mazerska
    Conference:
    VIII Konwersatorium Chemii Medycznej (year: 2016, pages: 73 (P-9)), Publisher: Polskie Towarzystwo Chemii Medycznej
    Date:
    conference 15 - 17.09.2016
    Status:
    Published

  3. C-1311 and C-1305-mediated mechanism based inhibition of CYP1A2 and CYP34A – insight into electrochemical identification and characterization of reactive metabolites.

    Authors:
    Agnieszka Potęga, Barbara Fedejko-Kap, Zofia Mazerska
    Conference:
    20th North American ISSX Meeting (year: 2015, pages: 95 - 96), Publisher: International Society for the Study of Xenobiotics
    Date:
    conference 18 - 22.10.2015
    Status:
    Published
    DOI:
    link to the publication

  4. Metabolizm leków – badania enzymatyczne vs. symulacja elektrochemiczna./Drug metabolism – enzymatic studies vs. electrochemical simulation.

    Authors:
    Agnieszka Potęga, Zofia Mazerska
    Conference:
    III Sympozjum Szkoła Chemii Medycznej (year: 2017, pages: 24 - 25 (W-4)), Publisher: Polskie Towarzystwo Farmaceutyczne
    Date:
    conference 06 - 08.09.2017
    Status:
    Published

  5. Electrochemical simulation of enzymatic transformations studied for the selected antitumor acridine derivatives

    Authors:
    Agnieszka Potęga, Weronika Hewelt-Belka, Olga Siewruk, Katarzyna Zapała, Zofia Mazerska
    Conference:
    VI Konwersatorium Chemii Medycznej (year: 2014, pages: 62-63), Publisher: Polskie Towarzystwo Chemii Medycznej
    Date:
    conference 18 - 20.09.2014
    Status:
    Published

  6. On-line electrochemistry-mass spectrometry (EC/MS) – A powerful tool for the prediction of drug oxidative metabolism reactions and their molecular mechanism.

    Authors:
    Agnieszka Potęga, Kamila Wilczewska, Zofia Mazerska
    Conference:
    13th European ISSX Meeting (year: 2015, pages: 60 - 61), Publisher: International Societ for the Study of Xenobiotics
    Date:
    conference 20 - 25.06.2015
    Status:
    Published
    DOI:
    link to the publication

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