Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Identification of the adhesins of pathogenic fungi Candida "non-albicans"

2012/07/B/NZ1/02867

Keywords:

candidiasis cell wall epithelial cells extracellular matrix proteins proteomics protein-protein interaction fluorescence spectroscopy surface plasmon resonance

Descriptors:

  • NZ1_10: Microbiology
  • NZ1_2: Biochemistry
  • NZ6_7: Mycology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

UNIWERSYTET JAGIELLOŃSKI, Wydział Biochemii Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Andrzej Kozik 

Number of co-investigators in the project: 7

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 775 000 PLN

Project start date (Y-m-d): 2013-07-08

Project end date (Y-m-d): 2016-07-07

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Półpreparatywne kolumny do chromatografii białek (40 000 PLN)
  2. Spektrofluorymetr przystosowany do pomiarów widm i polaryzacji fluorescencji w zakresie UV/VIS (150 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (6)
  1. Characterization of the interactions between human high-molecular-mass kininogen and cell wall proteins of pathogenic yeasts Candida tropicalis.
    Authors:
    J. Karkowska-Kuleta, D. Zajac, G. Bras, O. Bochenska, K. Seweryn, S. Kedracka-Krok, U. Jankowska, M. Rapala-Kozik, A. Kozik
    Academic press:
    Acta Biochimica Polonica (rok: 2016, tom: 63, strony: 427-436), Wydawca: Polish Biochemical Society and the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Status:
    Published
    DOI:
    10.18388/abp.2016_1353 - link to the publication
  2. Cell wall proteome of pathogenic fungi
    Authors:
    J. Karkowska-Kuleta, A. Kozik
    Academic press:
    Acta Biochimica Polonica (rok: 2015, tom: 62, strony: 339-351), Wydawca: Polish Biochemical Society and the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Status:
    Published
    DOI:
    10.18388/abp.2015_1032 - link to the publication
  3. Fibronectin-, vitronectin- and laminin-binding proteins at the cell walls of Candida parapsilosis and Candida tropicalis pathogenic yeasts
    Authors:
    A. Kozik, J. Karkowska-Kuleta, D. Zajac, O. Bochenska, S. Kedracka-Krok, U. Jankowska, M. Rapala-Kozik
    Academic press:
    BMC Microbiology (rok: 2015, tom: 15, strony: 197), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s12866-015-0531-4 - link to the publication
  4. Kinetic and thermodynamic characterization of the interactions between the components of human plasma kinin-forming system and isolated and purified cell wall proteins of Candida albicans
    Authors:
    K. Seweryn, J. Karkowska-Kuleta, N. Wolak, O. Bochenska, S. Kedracka-Krok, A. Kozik, M. Rapala-Kozik
    Academic press:
    Acta Biochimica Polonica (rok: 2015, tom: 62, strony: 825-835), Wydawca: Polish Biochemical Society and the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Status:
    Published
    DOI:
    10.18388/abp.2015_1142 - link to the publication
  5. Interaction of human fibronectin with Candida glabrata epithelial adhesin 6 (Epa6).
    Authors:
    D. Zajac, J. Karkowska-Kuleta, O. Bochenska, M. Rapala-Kozik, A. Kozik
    Academic press:
    Acta Biochimica Polonica (rok: 2016, tom: 63, strony: 417-426), Wydawca: Polish Biochemical Society and the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Status:
    Published
    DOI:
    10.18388/abp.2016_1328 - link to the publication
  6. Moonlighting proteins as virulence factors of pathogenic fungi, parasitic protozoa and multicellular parasites
    Authors:
    J. Karkowska-Kuleta, A. Kozik
    Academic press:
    Molecular Oral Microbiology (rok: 2014, tom: 29, strony: 270-283), Wydawca: John Wiley & Sons Ltd
    Status:
    Published
    DOI:
    10.1111/omi.12078 - link to the publication
  7. Surfaceome of pathogenic yeasts, Candida parapsilosis and Candida tropicalis, revealed with the use of cell surface shaving method and shotgun proteomic approach
    Authors:
    J. Karkowska-Kuleta, D. Zajac, O. Bochenska, A. Kozik
    Academic press:
    Acta Biochimica Polonica (rok: 2015, tom: 62, strony: 807-819), Wydawca: Polish Biochemical Society and the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Status:
    Published
    DOI:
    10.18388/abp.2015_1140 - link to the publication
  1. Characterization of vitronectin binding by proteins, isolated from Candida parapsilosis and Candida tropicalis cell walls.
    Authors:
    A. Kozik, D. Zajac, G. Bras, O. Bochenska, J. Karkowska-Kuleta, M. Rapala-Kozik
    Conference:
    13th ASM Conference on Candida and Canidiasis. Seattle, WA, USA (rok: 2016, ), Wydawca: American Society for Microbiology
    Data:
    konferencja 13.04. - 17.04.2016
    Status:
    Published
  2. Fibronectin, a multifunctional human glycoprotein, tightly binds to proteins exposed on the cell wall of pathogenic yeasts, Candida parapsilosis and Candida tropicalis
    Authors:
    J. Karkowska-Kuleta, D. Zajac, O. Bochenska, S. Kedracka-Krok, A. Kozik
    Conference:
    39th FEBS Congress, Paryż, Francja (rok: 2014, ), Wydawca: The FEBS Journal, Vol. 281 (Suppl. 1), John Wiley & Sons Ltd
    Data:
    konferencja 30.08 - 4.09.2014
    Status:
    Published
    DOI:
    link to the publication
  3. Identification of fibronectin-, vitronectin-, and laminin-binding proteins, associated with the cell walls of Candida parapsilosis and Candida tropicalis.
    Authors:
    A. Kozik, J. Karkowska-Kuleta, D. Zajac, O. Bochenska, S. Kedracka-Krok, U. Jankowska, M. Rapala-Kozik
    Conference:
    19th Congress of the International Society for Human and Animal Mycology, Melbourne, Australia (rok: 2015, ), Wydawca: ISHAM
    Data:
    konferencja 4.05 - 8.05.2015
    Status:
    Published
  4. Growth-dependent cell wall proteome and secretome of Candida glabrata.
    Authors:
    D. Zajac, J. Karkowska-Kuleta, O. Bochenska, A. Kozik
    Conference:
    6th International Weigl Conference on Microbiology, Gdansk (rok: 2015, ), Wydawca: Polish Biochemical Society and the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Data:
    konferencja 8.07. - 10.07.2015
    Status:
    Published
  5. Shedding light on Candida parapsilosis and Candida tropicalis secretome and surfaceome with the use of cell surface shaving method and shotgun proteomic approach.
    Authors:
    J. Karkowska-Kuleta, D. Zajac, O. Bochenska, A. Kozik
    Conference:
    6th International Weigl Conference on Microbiology, Gdansk (rok: 2015, ), Wydawca: Polish Biochemical Society and the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Data:
    konferencja 8.07. - 10.07.2015
    Status:
    Published
  6. Candida parapsilosis Cell-wall Adhesins Similar to Agglutinin-like Sequence (Als) Proteins are Involved in Binding of Fibronectin and Adhesion to Human Epithelial Cells.
    Authors:
    A. Kozik, D. Zajac, G. Bras, J. Karkowska-Kuleta, O. Bochenska, M. Rapala-Kozik
    Conference:
    ASM Microbe 2016, Boston, MA, USA (rok: 2016, ), Wydawca: American Society for Microbiology
    Data:
    konferencja 16.06. - 20.06.2016
    Status:
    Published

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