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The role of microparticles in pathomechanisms of diabetic retinopathy - analysis of intercellular communication mechanisms in endothelial aging

2012/07/B/NZ5/02510

Keywords

Descriptors

  • NZ5_3: Patogeneza chorób człowieka
  • NZ3_4: Starzenie
  • NZ4_4: Patofizjologia ogólna

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Lekarski

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Ewa Łucja Stępień

Number of co-investigators in the project: 7

Call

OPUS 4 – announced on 2012-09-15

Amount awarded
697 100 PLN
Project start date
2013-06-26
Project end date
2017-06-25
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. czytnik absorbancji, fluorescencji i luminescencji z oprogramowaniem do pomiarów kinetycznych, spektralnych i analizy odczytów. Cost: 90 000 PLN

Information in the final report

Publication in academic press/journals (9)

  1. The role of microparticles in pathomechanisms of diabetic retinopathy – analysis of intercellular communication mechanisms in endothelial aging. Case control study in patients with metabolic syndrome, diabetes type 1 and type 2

    Authors:
    Ewa Stępień, Iwona Szuścik, Aleksandra Tokarz, Francisco J. Enguita, Bogdan Solnica, Aleksander Żurakowski, Maciej Małecki
    Academic press:
    Journal of Medical Science (year: 2014, volume: 83, pages: 322-327), Publisher: Poznan University of Medical Sciences
    Status:
    Published

  2. Extracellular vesicles participate in the transport of cytokines and angiogenic factors in diabetic patients with ocular complications.

    Authors:
    Tokarz A, Szuścik I, Kuśnierz-Cabala B, Kapusta M, Konkolewska M, Żurakowski A, Georgescu A, Stępień E.
    Academic press:
    Folia Med Cracov (year: 2015, volume: 55, pages: 35-48), Publisher: PAN
    Status:
    Published
    DOI:
    link to the publication

  3. Urinary Extracellular Vesicles: Potential Biomarkers of Renal Function in Diabetic Patients

    Authors:
    Kamińska A, Platt M, Kasprzyk J, Kuśnierz-Cabala B, Gala-Błądzińska A, Woźnicka O, Jany BR, Krok F, Piekoszewski W, Kuźniewski M, Stępień EŁ
    Academic press:
    J Diabetes Res (year: 2016, volume: 2016, pages: 5741518), Publisher: Hindawi
    Status:
    Published
    DOI:
    10.1155/2016/5741518 – link to the publication

  4. Microparticles in endothelial function

    Authors:
    Ewa Stępień, Marta Targosz-Korecka
    Academic press:
    Postępy Biochemii (year: 2013, volume: 59, pages: 395-404), Publisher: Kwartalnik Polskiego Towarzystwa Biochemicznego
    Status:
    Published
    DOI:
    link to the publication

  5. Circulating ectosomes – targeting angiogenic microRNAs in diabetes

    Authors:
    Stępień E, Durak-Kozica M, Kamińska A, Targosz-Korecka M, Libera M, Tylko G Opalińska A, Kapusta M, Solnica B, Georgescu A, Costa M, Czyżewska-Buczyńska A, Witkiewicz W, Małecki M, Enguita FJ
    Academic press:
    Theranostics (year: 2018, volume: 8, pages: 3874-3890), Publisher: Ivyspring International Publisher Pty Ltd
    Status:
    Published
    DOI:
    10.7150/thno.23334 – link to the publication

  6. The effects of subdiffusion on the NTA size measurements of extracellular vesicles in biological samples

    Authors:
    M Majka, M Durak-Kozica, A Kamińska, A Opalińska, M Szczęch, E Stępień
    Academic press:
    arXiv.org>physics>biological physics (year: 2018, volume: 1701,09001, pages: 46040), Publisher: Cornell University Library
    Status:
    Published
    DOI:
    link to the publication

  7. Circulating Microvesicles in Regenerative Angiogenesis

    Authors:
    Drożdż A, Stępień E
    Academic press:
    Curr Trends in Biomed Eng & Bioscien (year: 2017, volume: 3;1, pages: 001-003), Publisher: JP Juniper Publishers
    Status:
    Published
    DOI:
    10.19080/CTBEB.2017.03.555602 – link to the publication

  8. Application of nano-LC-MALDI-TOF/TOF-MS for proteomic analysis of microvesicles.

    Authors:
    Kasprzyk J, Stępień E, Piekoszewski W.
    Academic press:
    Clin Biochem (year: 2017, volume: 50, pages: 241-243), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.clinbiochem.2016.11.013 – link to the publication

  9. Immobilization and detection of platelet-derived extracellular vesicles on functionalized silicon substrate: cytometric and spectrometric approach

    Authors:
    Gajos K, Kamińska A, Awsiuk K, Bajor A, Gruszczyński K, Pawlak A, Żądło A, Kowalik A, Budkowski A, Stępień E
    Academic press:
    Download PDF Analytical and Bioanalytical Chemistry (year: 2017, volume: 409, pages: 1109–1119), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00216-016-0036-5 – link to the publication

Articles in post-conference publications (7)

  1. Improved criteria of MVs size discrimination allow better characteristics of patients with controlled and uncontrolled diabetes mellitus.

    Authors:
    M. Durak, K. Rawojć, A.Tokarz, A. Opalińska, W. Łojkowski, E.L. Stepien.
    Conference:
    ISEV 2015 meeting. Washington DC (year: 2015, pages: 119), Publisher: Journal of Extracellular Vesicles 2015, 4: 27783
    Date:
    conference 23-26 April 2015
    Status:
    Published

  2. Urinary extracellular vesicles number and diameter as biomarkers of renal disease in diabetic patients

    Authors:
    Agnieszka Kaminska, Mark Platt, Beata Kusnierz-Cabala, Marek Kuzniewski, Ewa Stepien
    Conference:
    The Fifth International Meeting of ISEV (International Society for Extracellular Vesicles) (year: 2016, pages: 141), Publisher: Taylor & Francis Online
    Date:
    conference 4-7 Maja
    Status:
    Published

  3. Simplified method for proteome analysis of platelet-induced membrane vesicles

    Authors:
    Joanna Kasprzyk, Wojciech Piekoszewski, Ewa Stepien
    Conference:
    The Fifth International Meeting of ISEV (International Society of Extracellular Vesicles) (year: 2016, pages: 51), Publisher: Taylor & Francis Online
    Date:
    conference 4-7 maja
    Status:
    Published

  4. Human plasma microparticles are specific source of pro- and antiangiogenic miRNAs

    Authors:
    Ewa L. Stepien, Iwona Wybranska, Roman Pfitzner and Francisco J. Enguita
    Conference:
    ISEV 2014 Annual Meeting (year: 2014, pages: 94), Publisher: ISEV
    Date:
    conference 30.04-03.05
    Status:
    Published

  5. Interplay of RANTES chemokine and CCR5+ bearing microvesicles in diabetic retinopathy.

    Authors:
    Tokarz A, Drożdż AE, Szuścik I, STEPIEŃ E.
    Conference:
    ISEV 2017 International meeting, Toronto, Canada (year: 2017, pages: PF05.06; 1310414), Publisher: Taylor&Francis; Journal of Extracellular Vesicles
    Date:
    conference 18-21 May
    Status:
    Published
    DOI:
    link to the publication

  6. Circulating Tie2+ microvesicles as potential indicators of diabetic retinopathy progression.

    Authors:
    Tokarz A, Drożdż AE, Szuścik I, STEPIEŃ E.
    Conference:
    ISEV 2017 International meeting, Toronto, Canada (year: 2017, pages: PT06.08; 1310414), Publisher: Taylor&Francis, Journal of Extracellular Vesicles
    Date:
    conference 18-21 May
    Status:
    Published
    DOI:
    link to the publication

  7. Hyperglycemia induced microvesicles control endothelial cell migration.

    Authors:
    Drożdż AE, Jach R, Huras H, STĘPIEŃ E.
    Conference:
    ISEV 2017 International meeting, Toronto, Canada (year: 2017, pages: PF11.02; 1310414), Publisher: Taylor&Francis, Journal of Extracellular Vesicles
    Date:
    conference 18-21 May
    Status:
    Published
    DOI:
    link to the publication

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