Projects funded by the NCN
Elucidating the role of Mal and Pellino3 in anti-viral Toll-like Receptor signalling.
2012/07/B/NZ3/02550
Keywords:
IFNbeta anti-viral response TLR Mal Pellino3
Descriptors:
- NZ3_7: Signal transduction
- NZ3_1: Cell biology
Panel:
NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology
Host institution :
Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda PAN
woj. dolnośląskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 5
Call: OPUS 4 - announced on 2012-09-15
Amount awarded: 652 000 PLN
Project start date (Y-m-d): 2013-06-14
Project end date (Y-m-d): 2016-06-13
Project duration:: 36 months (the same as in the proposal)
Project status: Project settled
Equipment purchased [PL]
- Przystawka MousePOD wraz z systemem do anestezji do scanera IR Odyssay (120 000 PLN)
- System do hodowli myszy w klatkach indywidualnie wentylowanych szt. 1.
- Termocykler RealTime PCR szt. 1.
- Inkubator CO2 (25 000 PLN)
- Komora laminarna klasy 2 (39 000 PLN)
Information in the final report
- Publication in academic press/journals (2)
- Absence of Mal/TIRAP results in abrogated TLR7-dependent activation of IRF7 and suppressed IFN and IP-10 productionAuthors:Ewa Leszczyńska2, Joanna Zyzak1, Edyta Makuch1, Małgorzata Mitkiewicz1, Miwako Narita4, Paul N. Moynagh3, Tomasz Lipiński2, Jakub Siednienko1,2#Academic press:Journal of Immunology (rok: 2019, tom: -, strony: -), Wydawca: The American Association of ImmunologistsStatus:SubmittedDOI:
- HSV-1/TLR9-mediated IFNβ and TNFα induction is Mal-dependent in macrophagesAuthors:Joanna Zyzak1,2, Małgorzata Mitkiewicz1, Ewa Leszczyńska1,2, Patryk Reniewicz1,2, Paul N. Moynagh3, Jakub Siednienko1,2*Academic press:Journal of Innate Immunity (rok: 2019, tom: -, strony: -), Wydawca: KargerStatus:Accepted for publicationDOI: