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2-methoxyestradiol as physiological inducer of neuronal nitric oxide synthase (nNOS) in osteosarcoma apoptosis model

2012/07/B/NZ1/00010

Keywords

Descriptors

  • NZ1_1: Biologia molekularna
  • NZ1_2: Biochemia

Panel

NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution

Gdański Uniwersytet Medyczny, Wydział Lekarski

Voivodeship: pomorskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Michał Woźniak

Number of co-investigators in the project: 7

Call

OPUS 4 – announced on 2012-09-15

Amount awarded
843 800 PLN
Project start date
2013-07-17
Project end date
2017-01-16
Project duration
42 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. aparat do automatycznego wywoływania klisz RTG. Cost: 20 000 PLN
  2. aparat do liczenia komórek. Cost: 11 000 PLN
  3. aparaty do elektroforezy (małe i duże żele) i transferu białek wraz z zasilaczami oraz niezbędnym oprzyrządowaniem (2 pcs). Cost: 20 000 PLN
  4. aspirator butelkowy. Cost: 1 600 PLN
  5. fabrycznie nowy aparat do obrazowania żeli i membran otrzymanych techniką wetern blot.
  6. kostkarka do lodu. Cost: 3 500 PLN
  7. kołyska/wytrząsarka laboratoryjna. Cost: 4 500 PLN
  8. sprzęt komputerowy przenośny wraz z dyskiem zewnętrznym. Cost: 5 000 PLN
  9. wirówka z chłodzeniem. Cost: 15 000 PLN
  10. łaźnia wodna termostatowa. Cost: 4 000 PLN

Information in the final report

Publication in academic press/journals (9)

  1. 2-methoxyestradiol impacts on amino acids-mediated metabolic reprogramming in osteosarcoma cells by its interaction with NMDA receptor.

    Authors:
    MAGDALENA GORSKA-PONIKOWSKA*, UGO Perricone, Alicja Kuban-Jankowska, GIOSUE Lo Bosco, and Giampaolo BARONE
    Academic press:
    Journal of Cellular Physiology (year: 2017, volume: 232(11), pages: 3030-3049), Publisher: Journal of Cellular Physiology
    Status:
    Published
    DOI:
    10.1002/jcp.25888 – link to the publication

  2. DNA strand breaks induced by nuclear hijacking of neuronal NOS as an anti-cancer effect of 2-methoxyestradiol

    Authors:
    Gorska Magdalena*, Kuban-Jankowska Alicja, Wnuk Maciej, Rzeszutek Iwona, Zmijewski Michal A, Lewinska Anna, Gorzynik Monika, Daca Agnieszka, Marino Gammazza Antonella, Cappello Francesco, Wozniak Michal
    Academic press:
    Oncotarget (year: 2015, volume: 20;6, pages: 15449-63), Publisher: Oncotarget
    Status:
    Published

  3. Effect of 2-Methoxyestradiol on Dephosphorylation of Neuronal Nitric Oxide Synthase in Osteosarcoma 143B Cells. An in vitro study

    Authors:
    Gorska M*, Kuban-Jankowska A, Antoniewicz J , Wozniak M
    Academic press:
    Journal of Clinical Toxicology (year: 2015, volume: 5,2, pages: 46026), Publisher: Journal of Clinical Toxicology
    Status:
    Published
    DOI:
    10.4172/2161-0495.1000240 – link to the publication

  4. Heat shock proteins in main pediatric malignancies. A clinical overview

    Authors:
    Skora D, Gorska M*
    Academic press:
    Frontiers in Bioscience, Landmark Edition (year: 2016, volume: 21, pages: 157-64.), Publisher: Frontiers in Biosicence
    Status:
    Published
    DOI:
    10.2741/4381 – link to the publication

  5. Nitro-oxidative Stress Is Involved in Anticancer Activity of 17β-Estradiol Derivative in Neuroblastoma Cells

    Authors:
    Gorska, Kuban-Jankowska, Milczarek, Wozniak
    Academic press:
    Anticancer Research (year: 2016, volume: 36(4), pages: 1693-8), Publisher: Anticancer Research
    Status:
    Published

  6. Neuronal Nitric Oxide Synthase-Mediated Genotoxicity of 2-Methoxyestradiol in Hippocampal HT22 Cell Line.

    Authors:
    Gorska M, Zmijewski MA, Kuban-Jankowska A, Wnuk M, Rzeszutek I, Wozniak M.
    Academic press:
    Molecular Neurobiology (year: 2016, volume: 53(7), pages: 5030-40), Publisher: Molecular Neurobiology
    Status:
    Published
    DOI:
    10.1007/s12035-015-9434-5. – link to the publication

  7. Neuronal nitric oxide synthase induction in the antitumorigenic and neurotoxic effects of 2-methoxyestradiol.

    Authors:
    Gorska M*, Kuban-Jankowska A, Zmijewski M, Gorzynik M, Szkatula M, Wozniak M.
    Academic press:
    Molecules (year: 2014, volume: 19(9), pages: 13267-81), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules190913267. – link to the publication

  8. New insight into 2-methoxyestradiol- a possible physiological link between neurodegeneration and cancer cell death.

    Authors:
    Gorska, Kuban-Jankowska, Slawek, Wozniak
    Academic press:
    Current Medicinal Chemistry (year: 2016, volume: 23(15), pages: 1513-27), Publisher: Current Medicinal Chemistry
    Status:
    Published

  9. Impact of apparent antagonism of estrogen receptor β by fulvestrant on anticancer activity of 2-methoxyestradiol.

    Authors:
    Gorska Magdalena*, Roksana Maja Wyszkowska, Alicja Kuban-Jankowska, Michal Wozniak
    Academic press:
    Anticancer Research (year: 2016, volume: 36(5), pages: 2217-26), Publisher: Anticancer Research
    Status:
    Published

Articles in post-conference publications (8)

  1. Physiological and pharmacological consequences of 2-methoxyestradiol, a plausible novel hormone

    Authors:
    MAGDALENA GÓRSKA, ALICJA KUBAN-JANKOWSKA, MONIKA GORZYNIK, MICHAŁ ALEKSANDER ŻMIJEWSKI, M. Wnuk, I. Rzeszutek, A. Lewińska, MICHAŁ WOŹNIAK.
    Conference:
    BIO 2014 Congress: 1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics; 49th Meeting of the Polish Biochemical Society; 12th Conference of the Polish Society for Cell Biology; 16th Meeting of the Polish Biophysical Society; 7th Meeting of the Polish Bioinformatics Society, Warsaw, Poland, (year: 2014, pages: 144), Publisher: Acta Biochim. Pol. 2014; vol. 61, suppl. 1, s. 136, bibliogr. [3] poz.
    Date:
    conference September 9th-12th
    Status:
    Published

  2. Dual effects of 2-methoxyestradiol : anticancer agent and neurotoxin?

    Authors:
    MONIKA GORZYNIK, ALICJA KUBAN-JANKOWSKA, MICHAŁ A. ŻMIJEWSKI, AGNIESZKA DACA, MICHAŁ WOŹNIAK, MAGDALENA GÓRSKA.
    Conference:
    BIO 2014 Congress: 1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics; 49th Meeting of the Polish Biochemical Society; 12th Conference of the Polish Society for Cell Biology; 16th Meeting of the Polish Biophysical Society; 7th Meeting of the Polish Bioinformatics Society, Warsaw, Poland, (year: 2014, pages: 155), Publisher: Acta Biochim. Pol. 2014; vol. 61, suppl. 1, s. 147, bibliogr. 3 poz.
    Date:
    conference 9th-12th
    Status:
    Published

  3. Anticancer activity of oleuropein, the component of olive oil, in separate and combined treatment of main pediatric malignancies with potent chemotherapeutics - 2 methoxyestradiol and fulvestrant

    Authors:
    Magdalena Gorska
    Conference:
    Nu.Me Gdansk International Meeting, Obesity and Diabetes, Epidemiology and Pathogenesis (year: 2016, pages: 1), Publisher: Nu.Me Gdansk International Meeting
    Date:
    conference 25-27 maj
    Status:
    Published

  4. 2-metoksyestradiol jako naturalny czynnik przeciwnowotworowy w modelu śmierci komórkowej kostniakomięsaka

    Authors:
    EWELINA ZIELIŃSKA, MAGDALENA GÓRSKA, ALICJA KUBAN-JANKOWSKA, MICHAŁ WOŹNIAK.
    Conference:
    CNŚ : Człowiek Nauka Środowisko, (year: 2014, pages: p24), Publisher: Fundacja Centrum Transferu Technologii Synergy, 2014
    Date:
    conference 26-27 czerwca
    Status:
    Published

  5. Cumulative effects of vitamin D and 2-metoxyestradiol on inhibition of growth of osteosarcoma and melanoma cell lines

    Authors:
    JUSTYNA WIERZBICKA, P. Bieniasz-Krzywiec, MAGDALENA GÓRSKA, JAKUB ANTONIEWICZ, K. Wesołowska, ANNA PIOTROWSKA, KAROLINA SIWICKA, MONIKA GORZYNIK, MICHAŁ WOŹNIAK, MICHAŁ A. ŻMIJEWSKI.
    Conference:
    BIO 2014 Congress: 1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics; 49th Meeting of the Polish Biochemical Society; 12th Conference of the Polish Society for Cell Biology; 16th Meeting of the Polish Biophysical Society; 7th Meeting of the Polish Bioinformatics Society, Warsaw, Poland, September 9th-12th 2014 : abstracts (year: 2014, pages: 57), Publisher: Acta Biochim. Pol. 2014; vol. 61, suppl. 1, s. 56
    Date:
    conference September 9th-12th 2014
    Status:
    Published

  6. Anticancer activity and molecular signalling of potent chemotherapeutics- 2-methoxyestradiol and fulvestrant in therapy of osteosarcoma.

    Authors:
    Magdalena Gorska, Alicja Kuban-Jankowska, Roksana Wyszkowska, Michal Zmijewski, Cappello Francesco, Michal Wozniak
    Conference:
    5th Portuguese Young Chemists Meeting (5th PYCheM) (year: 2016, pages: S. 59 : Bibliogr. 4 poz.), Publisher: 5th Portuguese Young Chemists Meeting (5th PYCheM)
    Date:
    conference 26-29.04.2016
    Status:
    Published

  7. Control of mitochondrial biogenesis and function as an anticancer approach - impact of 2-methoxyestradiol and fulvestrant on mitochondria in highly metastatic osteosarcoma 143B.

    Authors:
    Magdalena Gorska*, Alicja Kuban-Jankowska, Mariusz Karbowski, Jan Spodnik, Wojciech Sawczuk, Roksana Wyszkowska, Takashi Wakabayashi, Micha Wozniakl
    Conference:
    Mito2015 - Mitochondria in life, death and disease 2015 (year: 2015, pages: 39), Publisher: Mito 2015
    Date:
    conference 12-16.10.2015
    Status:
    Published

  8. Physiological and pharmacological effects of 2-methoxyestradiol

    Authors:
    Magdalena Gorska, Alicja Kuban-Jankowska, Michal A. Zmijewski, Maciej Wnuk, Monika Gorzynik, Iwona Rzeszutek, Michal Wozniak
    Conference:
    Frontiers in Cancer Prevention: Fulfilled Promises, Translational Challenges and Future Directions (year: 2015, pages: 34), Publisher: Frontiers in Cancer Prevention: Fulfilled Promises, Translational Challenges and Future Directions
    Date:
    conference 24-26.06.2015
    Status:
    Published

Book publications / chapters in book publications (2)

  1. Syntazy tlenku azotu (NOSs) jako nowy cel terapeutyczny dla leków antynowotworowych

    Authors:
    Gorska Magdalena
    Book:
    Na pograniczu biologii i chemii, pod red. H. Koroniaka i J. Barciszewskiego (year: 2014, volume: 32, pages: 107-119), Publisher: Poznań : Wydawnictwo Naukowe Uniwersytetu im. Adama Mickiewicza
    Status:
    Published

  2. Białka szoku termicznego HSPs – potencjalne markery diagnostyczne oraz cel terapeutyczny dla leków antynowotworowych nowej generacji

    Authors:
    Dorota Skóra, Monika Gorzynik, Alicja Kuban-Jankowska, Maciej Niedźwiecki, Elżbieta Adamkiewicz-Drozynska, Michał Woźniak Magdalena Górska*
    Book:
    Na pograniczu biologii i chemii, pod red. H. Koroniaka i J. Barciszewskiego (year: 2014, volume: 32, pages: 331-348), Publisher: Poznań : Wydawnictwo Naukowe Uniwersytetu im. Adama Mickiewicza
    Status:
    Published

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