Synthesis of biologically important 2-alkylidene-1-oxoheterocycles using Horner-Wadsworth-Emmons approach
2012/07/B/ST5/02006
Keywords
Descriptors
- ST5_23: Chemia organiczna
Panel
ST5 – Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering
Host institution
Politechnika Łódzka, Wydział Chemiczny
Voivodeship: łódzkie
Principal investigator (from the host institution)
Number of co-investigators in the project: 10
Call
OPUS 4 – announced on 2012-09-15
- Amount awarded
- 575 000 PLN
- Project start date
- 2013-09-13
- Project end date
- 2017-09-12
- Project duration
- 48 months (the same as in the proposal)
- Project status
- Project settled
Equipment purchased [PL]
- Laboratoryjny system próżniowy, chemoodporny. Cost: 14 000 PLN
- Laboratoryjny zestaw próżniowy z pompą membranową i kontrolerem próżni.
- Pompa strzykawkowa. Cost: 10 000 PLN
- Suszarka laboratoryjna. Cost: 5 000 PLN
- Wyparka Buchi z pionową chłodnicą (chillerem). Cost: 16 000 PLN
Information in the final report
Publication in academic press/journals (8)
-
Asymmetric synthesis of 1,4-disubstituted 3-methylidenedihydroquinolin-2(1H)-ones
- Authors:
- Marlena Pięta, Jacek Kędzia, Jakub Wojciechowski, Tomasz Janecki
- Academic press:
- Tetrahedron: Asymmetry (year: 2017, volume: 28, pages: 567-576), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.tetasy.2017.03.010 – link to the publication
-
Highly syn-diastereoselective Michael addition of enolizable ketones to 3-(diethoxyphosphoryl)coumarin
- Authors:
- D. Deredas, K. Huben, W. Maniukiewicz, H. Krawczyk
- Academic press:
- Tetrahedron (year: 2014, volume: 70, pages: 8925-8929), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.tet.2014.09.064 – link to the publication
-
Novel synthesis and cytotoxic activity of 1,4-disubstituted 3-methylidene-3,4-dihydroquinolin2(1H)-ones
- Authors:
- M. Pięta, J. Kędzia, A. Janecka, D. K. Pomorska, M. Różalski, U. Krajewska, T. Janecki
- Academic press:
- RSC Advances (year: 2015, volume: 5, pages: 78324-78335), Publisher: The Royal Society of Chemistry
- Status:
- Published
- DOI:
- 10.1039/c5ra16673j – link to the publication
-
Synthesis and anticancer properties of 3 - methylene - 4 - (2 - oxoalkyl) - 3,4 - dihydrocoumarins
- Authors:
- D. Deredas, K. Huben, A. Janecka, A. Długosz, D. K. Pomorska, M. Mirowski, U. Krajewska, T. Janecki and H. Krawczyk
- Academic press:
- MedChemComm. (year: 2016, volume: 7, pages: 11745-1756), Publisher: The Royal Society of Chemistry
- Status:
- Published
- DOI:
- 10.1039/c6md00118a – link to the publication
-
Synthesis of novel 4,4-disubstituted 3-methylidenechroman-2-ones as potent anticancer agents
- Authors:
- Rafał Jakubowski, Dorota K. Pomorska, Angelika Długosz, Anna Janecka, Urszula Krajewska, Marek Różalski, Marek Mirowski, Tomasz Bartosik, Tomasz Janecki
- Academic press:
- ChemMedChem (year: 2017, volume: 12, pages: 599-605), Publisher: WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
- Status:
- Published
- DOI:
- 10.1002/cmdc.201700080 – link to the publication
-
Synthesis of substituted methylidenepyrimidobenzothiazolones as potential cytotoxic agents
- Authors:
- J. Modranka, A. Pietrzak, W. M. Wolf, and T. Janecki
- Academic press:
- Arkivoc (year: 2017, volume: part ii, pages: 118-137), Publisher: ARKAT USA, Inc.
- Status:
- Published
- DOI:
- 10.3998/ark.5550190.p009.707 – link to the publication
-
Anticancer properties of a new hybrid analog AD-013 combining a coumarin scaffold with an α-methylene-δ-lactone motif
- Authors:
- Angelika Długosz, Katarzyna Gach-Janczak, Jacek Szymański, Dariusz Deredas, Henryk Krawczyk, Tomasz Janecki, Anna Janecka
- Status:
- Accepted for publication
-
Involvement of a-methylene-g- and d-lactones in the suppression of multidrug resistance in MCF-7 cells
- Authors:
- Angelika Długosz, Katarzyna Gach-Janczak, Jacek Szyma´nski, Dariusz Deredas, Tomasz Janecki, Anna Janecka
- Status:
- Accepted for publication