Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Synthesis of biologically important 2-alkylidene-1-oxoheterocycles using Horner-Wadsworth-Emmons approach

2012/07/B/ST5/02006

Keywords:

Horner-Wadsworth-Emmons reaction phosphorylated heterocycles a-methylene-g- and d-lactones and lactams cytotoxicity

Descriptors:

  • ST5_23:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Politechnika Łódzka, Wydział Chemiczny

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Tomasz Janecki 

Number of co-investigators in the project: 10

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 575 000 PLN

Project start date (Y-m-d): 2013-09-13

Project end date (Y-m-d): 2017-09-12

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Laboratoryjny system próżniowy, chemoodporny (14 000 PLN)
  2. Pompa strzykawkowa (10 000 PLN)
  3. Wyparka Buchi z pionową chłodnicą (chillerem) (16 000 PLN)
  4. Laboratoryjny zestaw próżniowy z pompą membranową i kontrolerem próżni.
  5. Suszarka laboratoryjna (5 000 PLN)

Information in the final report

  • Publication in academic press/journals (9)
  1. Highly syn-diastereoselective Michael addition of enolizable ketones to 3-(diethoxyphosphoryl)coumarin
    Authors:
    D. Deredas, K. Huben, W. Maniukiewicz, H. Krawczyk
    Academic press:
    Tetrahedron (rok: 2014, tom: 70, strony: 8925-8929), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tet.2014.09.064 - link to the publication
  2. Synthesis of substituted methylidenepyrimidobenzothiazolones as potential cytotoxic agents
    Authors:
    J. Modranka, A. Pietrzak, W. M. Wolf, and T. Janecki
    Academic press:
    Arkivoc (rok: 2017, tom: part ii, strony: 118-137), Wydawca: ARKAT USA, Inc.
    Status:
    Published
    DOI:
    10.3998/ark.5550190.p009.707 - link to the publication
  3. Involvement of a-methylene-g- and d-lactones in the suppression of multidrug resistance in MCF-7 cells
    Authors:
    Angelika Długosz, Katarzyna Gach-Janczak, Jacek Szyma´nski, Dariusz Deredas, Tomasz Janecki, Anna Janecka
    Academic press:
    Pharmacological Reports (rok: 2018, ), Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    10.1016/j.pharep.2018.01.002 - link to the publication
  4. Anticancer properties of a new hybrid analog AD-013 combining a coumarin scaffold with an α-methylene-δ-lactone motif
    Authors:
    Angelika Długosz, Katarzyna Gach-Janczak, Jacek Szymański, Dariusz Deredas, Henryk Krawczyk, Tomasz Janecki, Anna Janecka
    Academic press:
    Anti-Cancer Agents in Medicinal Chemistry (rok: 2017, tom: 17, strony: ), Wydawca: Bentham Science
    Status:
    Accepted for publication
    DOI:
    10.2174/1871520617666170921123654 - link to the publication
  5. Asymmetric synthesis of 1,4-disubstituted 3-methylidenedihydroquinolin-2(1H)-ones
    Authors:
    Marlena Pięta, Jacek Kędzia, Jakub Wojciechowski, Tomasz Janecki
    Academic press:
    Tetrahedron: Asymmetry (rok: 2017, tom: 28, strony: 567-576), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tetasy.2017.03.010 - link to the publication
  6. Novel synthesis and cytotoxic activity of 1,4-disubstituted 3-methylidene-3,4-dihydroquinolin2(1H)-ones
    Authors:
    M. Pięta, J. Kędzia, A. Janecka, D. K. Pomorska, M. Różalski, U. Krajewska, T. Janecki
    Academic press:
    RSC Advances (rok: 2015, tom: 5, strony: 78324-78335), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c5ra16673j - link to the publication
  7. Synthesis of novel 4,4-disubstituted 3-methylidenechroman-2-ones as potent anticancer agents
    Authors:
    Rafał Jakubowski, Dorota K. Pomorska, Angelika Długosz, Anna Janecka, Urszula Krajewska, Marek Różalski, Marek Mirowski, Tomasz Bartosik, Tomasz Janecki
    Academic press:
    ChemMedChem (rok: 2017, tom: 12, strony: 599-605), Wydawca: WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
    Status:
    Published
    DOI:
    10.1002/cmdc.201700080 - link to the publication
  8. Novel synthesis of 3-methylidene-1-tosyl-2,3-dihydroquinolin-4(1H)-ones as potent anticancer agents
    Authors:
    Jacek Koszuk, Tomasz Bartosik, Jakub Wojciechowski, Wojciech Wolf, Anna Janecka, Joanna Drogosz, Angelika Długosz, Urszula Krajewska, Marek Mirowski, Tomasz Janecki
    Academic press:
    New Journal of Chemistry , Wydawca: Royal Society of Chemistry
    Status:
    Submitted
    DOI:
    brak - link to the publication
  9. Synthesis and anticancer properties of 3 - methylene - 4 - (2 - oxoalkyl) - 3,4 - dihydrocoumarins
    Authors:
    D. Deredas, K. Huben, A. Janecka, A. Długosz, D. K. Pomorska, M. Mirowski, U. Krajewska, T. Janecki and H. Krawczyk
    Academic press:
    MedChemComm. (rok: 2016, tom: 7, strony: 11745-1756), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c6md00118a - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy