Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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The role of endplate calcification, nutritional vessel occlusion and proteins responsible for the elaboration of inorganic pyrophosphate in the pathogenesis of cervical disc degenerative disease.

2012/07/N/NZ5/00078

Keywords:

intervertebral disk degenerative disease cervical disks endplate scanning electron microscopy vasculature ANK VDR

Descriptors:

  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydzial Lekarski

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Krzysztof Tomaszewski 

Number of co-investigators in the project: 2

Call: PRELUDIUM 4 - announced on 2012-09-15

Amount awarded: 99 970 PLN

Project start date (Y-m-d): 2013-06-18

Project end date (Y-m-d): 2015-06-17

Project duration:: 24 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (5)
  1. Age- and degeneration-related variations in cell density and glycosaminoglycan content in the human cervical intervertebral disc and its endplates.
    Authors:
    Tomaszewski KA, Walocha JA, Mizia E, Gładysz T, Głowacki R, Tomaszewska R.
    Academic press:
    Polish Journal of Pathology (rok: 2015, tom: 66, strony: 296-309), Wydawca: Termedia
    Status:
    Published
    DOI:
    10.5114/pjp.2015.54964 - link to the publication
  2. Degeneration and calcification of the cervical endplate is connected with a decreased expression of ANK, ENPP-1, OPN and TGF-β1 in the intervertebral disc.
    Authors:
    Tomaszewski KA, Adamek D, Pasternak A, Głowacki R, Tomaszewska R, Walocha JA.
    Academic press:
    Polish Journal of Pathology (rok: 2014, tom: 65, strony: 204-211), Wydawca: Termedia
    Status:
    Published
    DOI:
    10.5114/pjp.2014.45783 - link to the publication
  3. Validation of the intervertebral disc histological degeneration score in cervical intervertebral discs and their end plates
    Authors:
    Tomaszewski KA, Henry BM, Gładysz T, Głowacki R, Walocha JA, Tomaszewska R
    Academic press:
    The Spine Journal (rok: 2017, tom: 17, strony: 738-745), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.spinee.2017.01.006 - link to the publication
  4. The biology behind the human intervertebral disc and its endplates.
    Authors:
    Tomaszewski KA, Saganiak K, Gładysz T, Walocha JA.
    Academic press:
    Folia Morphologica (rok: 2015, tom: 74, strony: 157-168), Wydawca: Via Medica
    Status:
    Published
    DOI:
    10.5603/FM.2015.0026 - link to the publication
  5. Endplate calcification and cervical intervertebral disc degeneration – the role of endplate marrow contact channel occlusion.
    Authors:
    Tomaszewski KA, Adamek D, Konopka T, Tomaszewska R, Walocha JA.
    Academic press:
    Folia Morphologica (rok: 2015, tom: 74, strony: 84-92), Wydawca: Via Medica
    Status:
    Published
    DOI:
    10.5603/FM.2015.0014 - link to the publication

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