Zmiana języka

Projects search

May post-translational non-enzymatic modifications of platelet proteins contribute to altered platelet adhesion to endothelium under conditions of severe hyperglycaemia? DM as a model underlying atherothrombosis derived from protein glycation.

2012/06/A/NZ5/00069

Keywords

Descriptors

  • NZ5_3: Patogeneza chorób człowieka
  • NZ5_7: Leczenie chorób człowieka
  • NZ1_2: Biochemia

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Uniwersytet Medyczny w Łodzi, Wydział Nauk o Zdrowiu

Voivodeship: łódzkie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Cezary Wojciech Watała

Number of co-investigators in the project: 12

Call

MAESTRO 3 – announced on 2012-06-15

Amount awarded
2 515 000 PLN
Project start date
2013-03-25
Project end date
2018-12-24
Project duration
69 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Aparat do elektroforezy.
  2. Destylarka. Cost: 8 000 PLN
  3. Wytrząsarka do płytek mikrotitracyjnych. Cost: 5 000 PLN
  4. Zestaw do badania adhezji w warunkach kontrolowanego przepływu. Cost: 87 000 PLN
  5. Zestaw mikroskopowy do fluorescencyjnej mikroskopii przyżyciowej. Cost: 160 000 PLN
  6. Zestaw mikroskopowy odwrócony. Cost: 240 000 PLN

Information in the final report

Publication in academic press/journals (8)

  1. Higher mitochondrial potential and elevated mitochondrial respiration associate with excessive activation of blood platelets in diabetic rats

    Authors:
    K. Siewiera, H. Kassassir, M. Talar, L. Wieteska, C. Watala
    Academic press:
    Life Sciences (year: 2016, volume: 148, pages: 293-304), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.lfs.2016.02.030 – link to the publication

  2. Non-enzymatic modifications of prostaglandin H synthase 1 affect bifunctional enzyme activity – implications for the sensitivity of blood platelets to acetylsalicylic acid

    Authors:
    Hassan Kassassir, Karolina Siewiera, Marcin Talar, Emilia Stec-Martyna, Zofia Pawlowska, Cezary Watala
    Academic press:
    Chemico-Biological Interactions (year: 2016, volume: 253, pages: 78-92), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cbi.2016.04.021 – link to the publication

  3. Inhibition of cyclooxygenase-2 causes decrease in coronary flow in diabetic mice. Possible role of PGE2 and dysfunctional vasodilation mediated by prostacyclin receptor.

    Authors:
    Przygodzki T, Talar M, Przygodzka P, Watala C,
    Academic press:
    Journal of Physiology and Biochemistry (year: 2015, volume: 71, pages: 351-358), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s13105-015-0415-y – link to the publication

  4. Long-term untreated streptozotocin-diabetes leads to increased expression and elevated activity of prostaglandin H2 synthase in blood platelets.

    Authors:
    Siewiera K, Kassassir H, Talar M, Wieteska L, Watala C.
    Academic press:
    Platelets (year: 2015, volume: 1, pages: 46031), Publisher: Taylor & Francis
    Status:
    Published
    DOI:
    10.3109/09537104.2015.1075492 – link to the publication

  5. Flow cytometry analysis reveals different activation profiles of thrombin- or TRAP-stimulated platelets in db/db mice. The regulatory role of PAR-3.

    Authors:
    Kassassir H, Siewiera K, Talar M, Przygodzki T, Watala C.
    Academic press:
    Blood Cells, Molecules and Diseases (year: 2017, volume: 65, pages: 16-22), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bcmd.2017.03.011 – link to the publication

  6. Enhanced adhesion of blood platelets to intact endothelium of mesenteric vascular bed in mice with streptozotocin-induced diabetes is mediated by an up-regulated endothelial surface deposition of VWF - In vivo study.

    Authors:
    Przygodzki T, Talar M, Kassassir H, Mateuszuk L, Musial J, Watala C.
    Academic press:
    Platelets (year: 2018, volume: 29, pages: 476-485), Publisher: Taylor and Francis
    Status:
    Published
    DOI:
    10.1080/09537104.2017.1332365 – link to the publication

  7. Effects of three-month streptozotocin-induced diabetes in mice on blood platelet reactivity, COX-1 expression and adhesion potential.

    Authors:
    Przygodzki T, Kassassir H, Talar M, Siewiera K, Watala C
    Academic press:
    International Journal of Experimental Pathology (year: 2019, volume: 100, pages: 41-48), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1111/iep.12298 – link to the publication

  8. Quantification of the Blood Platelet Reactivity in the ADP-Induced Model of Non-Lethal Pulmonary Thromboembolism in Mice with the Use of Laser Doppler Flowmetry.

    Authors:
    Przygodzki T, Talar M, Blazejczyk A, Kalchenko V, Watala C.
    Academic press:
    PLoS One (year: 2016, volume: 11, pages: 46035), Publisher: PLoS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0146346 – link to the publication

Articles in post-conference publications (10)

  1. OXIDATION OF C-REACTIVE PROTEIN BY HYPOCHLOROUS ACID LEADS TO THE FORMATION OF POTENT PLATELET ACTIVATOR

    Authors:
    M. Boncler , B.E. Kehler , R. Bednarek , D. Dudzinska , & C. Watala
    Conference:
    UK Platelet Meeting (year: 2015, pages: 4), Publisher: Taylor&Francis
    Date:
    conference 15-16 września
    Status:
    Published
    DOI:
    link to the publication

  2. EVALUATION OF BLOOD PLATELET ADHESIVENESS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS UNDER FLOW CONDITIONS

    Authors:
    Tomasz Przygodzki, Boguslawa Luzak, Lidia Stanczyk, Marcin Kosmalski, Hassan Kassassir, Józef Drzewoski, Cezary Watala
    Conference:
    1st Italian- UK Platelet Meeting (year: 2017, pages: 755-756), Publisher: Taylor and Francis
    Date:
    conference 7-8.09.2017
    Status:
    Published

  3. DOES NON-ENZYMATIC GLYCOSYLATION INVOLVE PLATELET GLYCOPROTEIN IIBIIIA AND AFFECT RECEPTOR-LIGAND INTERACTION? – A PRELIMINARY STUDY

    Authors:
    M. Boncler , E. Stec-Martytna , & C. Watala
    Conference:
    UK Platelet Meeting (year: 2015, pages: 24), Publisher: Taylor&Francis
    Date:
    conference 15-16 września
    Status:
    Published
    DOI:
    link to the publication

  4. QUANTIFICATION OF BLOOD PLATELET REACTIVITY IN MODEL OF ADP-INDUCED NON-LETHAL PULMONARY THROMBOEMBOLISM IN MICE WITH THE USE OF LASER DOPPLER FLOWMETRY

    Authors:
    Tomasz Przygodzki , Marcin Talar , Agnieszka Blazejczyk , Vyacheslav Kalchenko , & Cezary Watala
    Conference:
    UK Platelet Meeting (year: 2015, pages: 21), Publisher: Taylor&Francis
    Date:
    conference 15-16 września
    Status:
    Published
    DOI:
    link to the publication

  5. BLOOD PLATELETS' ADHESION TO ENDOTHELIUM IS INCREASED IN VIVO IN MICE WITH STREPTOZOTOCININDUCED DIABETES

    Authors:
    Tomasz Przygodzki, Marcin Talar, Hassan Kassassir, & Cezary Watala
    Conference:
    UK Platelet Meeting (year: 2015, pages: 16), Publisher: Taylor&Francis
    Date:
    conference 15-16 września
    Status:
    Published
    DOI:
    link to the publication

  6. ASSOCIATIONS BETWEEN ADHESION OF HUMAN BLOOD PLATELETS TO FIBRINOGEN AND VON WILLEBRAND FACTOR UNDER FLOW CONDITIONS AND FLOW CYTOMETRIC HALLMARKS OF PLATELET ACTIVATION AND REACTIVITY. STUDY IN DIABETIC PATIENTS AND NON-DIABETIC VOLUNTEERS

    Authors:
    Tomasz Przygodzki, Boguslawa Luzak, & Cezary Watala
    Conference:
    UK Platelet Meeting (year: 2015, pages: 17), Publisher: Taylor&Francis
    Date:
    conference 15-16 września
    Status:
    Published
    DOI:
    link to the publication

  7. NIEENZYMATYCZNE MODYFIKACJE PŁYTKOWEJ CYKLOOKSYGENAZY 1 – CZY GLIKACJA MOŻE ZMNIEJSZAĆ WRAŻLIWOŚC PŁYTEK KRWI NA DZIAŁANIE KWASU ACETYLOSALICYLOWEGO?

    Authors:
    Cezary Watala, Hassan Kassassir, Karolina Siewiera, Emilia Stec-Martyna, Zofia Pawłowska
    Conference:
    58 Zjazd Naukowy Polskiego Towarzystwa Chemicznego, Gdańsk (year: 2015, pages: 305), Publisher: Polskiego Towarzystwo Chemiczne
    Date:
    conference 21-25 listopada
    Status:
    Published

  8. Decresaed CD61 expression on platelet membranes is a common characteristics of type 2 diabetic patients, streptozotocin-dabetic rats and in vitro model of hyperglycemia. Consequences for platelet adhesion

    Authors:
    N. Wolska, T. Przygodzki, M. Talar, M. Gapinska, C. Watala, M. Rozalski,
    Conference:
    4th Euplan Conference (year: 2018, pages: 78), Publisher: KU Leuven
    Date:
    conference 19-21 września
    Status:
    Published

  9. Parameters of blood morphology and platelet activation undergo changes during progression of streptozotocininduced diabetes in rats

    Authors:
    K. Siewiera, H. Kassassir, T. Przygodzki, D. Polak, N. Wolska, M. Talar, C. Watala
    Conference:
    25th Krakow Conference on Endothelium (year: 2017, pages: 63, 89), Publisher: Jagiellonian Centre for Experimental Therapeutics
    Date:
    conference 20-21 października
    Status:
    Published

  10. ALTERED BLOOD PLATELET ACTIVATION IS NOT RELATED TO ELEVATED MITOCHONDRIAL RESPIRATION IN RAT MODEL OF STREPTOZOTOCIN-INDUCED DIABETES

    Authors:
    Karolina Siewiera, Magdalena Labieniec-Watala, Hassan Kassassir, Dawid Polak, Nina Wolska, & Cezary Watala
    Conference:
    1st Italian- UK Platelet Meeting (year: 2017, pages: 747), Publisher: Taylor and Francis
    Date:
    conference 7-8.09.2017
    Status:
    Published

« New search

Graphic design and implementation: Jakub Piotrowski