Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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May post-translational non-enzymatic modifications of platelet proteins contribute to altered platelet adhesion to endothelium under conditions of severe hyperglycaemia? DM as a model underlying atherothrombosis derived from protein glycation.

2012/06/A/NZ5/00069

Keywords:

diabetes glycation AGEs blood platelets,vascular endothelium

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_7: Human disease treatment
  • NZ1_2: Biochemistry

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Nauk o Zdrowiu

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Cezary Watała 

Number of co-investigators in the project: 12

Call: MAESTRO 3 - announced on 2012-06-15

Amount awarded: 2 515 000 PLN

Project start date (Y-m-d): 2013-03-25

Project end date (Y-m-d): 2018-12-24

Project duration:: 69 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Zestaw do badania adhezji w warunkach kontrolowanego przepływu (87 000 PLN)
  2. Aparat do elektroforezy.
  3. Destylarka (8 000 PLN)
  4. Wytrząsarka do płytek mikrotitracyjnych (5 000 PLN)
  5. Zestaw mikroskopowy do fluorescencyjnej mikroskopii przyżyciowej (160 000 PLN)
  6. Zestaw mikroskopowy odwrócony (240 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  • Articles in post-conference publications (10)
  1. Long-term untreated streptozotocin-diabetes leads to increased expression and elevated activity of prostaglandin H2 synthase in blood platelets.
    Authors:
    Siewiera K, Kassassir H, Talar M, Wieteska L, Watala C.
    Academic press:
    Platelets (rok: 2015, tom: 1, strony: 45300), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.3109/09537104.2015.1075492 - link to the publication
  2. Flow cytometry analysis reveals different activation profiles of thrombin- or TRAP-stimulated platelets in db/db mice. The regulatory role of PAR-3.
    Authors:
    Kassassir H, Siewiera K, Talar M, Przygodzki T, Watala C.
    Academic press:
    Blood Cells, Molecules and Diseases (rok: 2017, tom: 65, strony: 16-22), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bcmd.2017.03.011 - link to the publication
  3. Effects of three-month streptozotocin-induced diabetes in mice on blood platelet reactivity, COX-1 expression and adhesion potential.
    Authors:
    Przygodzki T, Kassassir H, Talar M, Siewiera K, Watala C
    Academic press:
    International Journal of Experimental Pathology (rok: 2019, tom: 100, strony: 41-48), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/iep.12298 - link to the publication
  4. Higher mitochondrial potential and elevated mitochondrial respiration associate with excessive activation of blood platelets in diabetic rats
    Authors:
    K. Siewiera, H. Kassassir, M. Talar, L. Wieteska, C. Watala
    Academic press:
    Life Sciences (rok: 2016, tom: 148, strony: 293-304), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.lfs.2016.02.030 - link to the publication
  5. Quantification of the Blood Platelet Reactivity in the ADP-Induced Model of Non-Lethal Pulmonary Thromboembolism in Mice with the Use of Laser Doppler Flowmetry.
    Authors:
    Przygodzki T, Talar M, Blazejczyk A, Kalchenko V, Watala C.
    Academic press:
    PLoS One (rok: 2016, tom: 11, strony: 45304), Wydawca: PLoS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0146346 - link to the publication
  6. Enhanced adhesion of blood platelets to intact endothelium of mesenteric vascular bed in mice with streptozotocin-induced diabetes is mediated by an up-regulated endothelial surface deposition of VWF - In vivo study.
    Authors:
    Przygodzki T, Talar M, Kassassir H, Mateuszuk L, Musial J, Watala C.
    Academic press:
    Platelets (rok: 2018, tom: 29, strony: 476-485), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1080/09537104.2017.1332365 - link to the publication
  7. Inhibition of cyclooxygenase-2 causes decrease in coronary flow in diabetic mice. Possible role of PGE2 and dysfunctional vasodilation mediated by prostacyclin receptor.
    Authors:
    Przygodzki T, Talar M, Przygodzka P, Watala C,
    Academic press:
    Journal of Physiology and Biochemistry (rok: 2015, tom: 71, strony: 351-358), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s13105-015-0415-y - link to the publication
  8. Non-enzymatic modifications of prostaglandin H synthase 1 affect bifunctional enzyme activity – implications for the sensitivity of blood platelets to acetylsalicylic acid
    Authors:
    Hassan Kassassir, Karolina Siewiera, Marcin Talar, Emilia Stec-Martyna, Zofia Pawlowska, Cezary Watala
    Academic press:
    Chemico-Biological Interactions (rok: 2016, tom: 253, strony: 78-92), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cbi.2016.04.021 - link to the publication
  1. Decresaed CD61 expression on platelet membranes is a common characteristics of type 2 diabetic patients, streptozotocin-dabetic rats and in vitro model of hyperglycemia. Consequences for platelet adhesion
    Authors:
    N. Wolska, T. Przygodzki, M. Talar, M. Gapinska, C. Watala, M. Rozalski,
    Conference:
    4th Euplan Conference (rok: 2018, ), Wydawca: KU Leuven
    Data:
    konferencja 19-21 września
    Status:
    Published
  2. ASSOCIATIONS BETWEEN ADHESION OF HUMAN BLOOD PLATELETS TO FIBRINOGEN AND VON WILLEBRAND FACTOR UNDER FLOW CONDITIONS AND FLOW CYTOMETRIC HALLMARKS OF PLATELET ACTIVATION AND REACTIVITY. STUDY IN DIABETIC PATIENTS AND NON-DIABETIC VOLUNTEERS
    Authors:
    Tomasz Przygodzki, Boguslawa Luzak, & Cezary Watala
    Conference:
    UK Platelet Meeting (rok: 2015, ), Wydawca: Taylor&Francis
    Data:
    konferencja 15-16 września
    Status:
    Published
    DOI:
    link to the publication
  3. OXIDATION OF C-REACTIVE PROTEIN BY HYPOCHLOROUS ACID LEADS TO THE FORMATION OF POTENT PLATELET ACTIVATOR
    Authors:
    M. Boncler , B.E. Kehler , R. Bednarek , D. Dudzinska , & C. Watala
    Conference:
    UK Platelet Meeting (rok: 2015, ), Wydawca: Taylor&Francis
    Data:
    konferencja 15-16 września
    Status:
    Published
    DOI:
    link to the publication
  4. ALTERED BLOOD PLATELET ACTIVATION IS NOT RELATED TO ELEVATED MITOCHONDRIAL RESPIRATION IN RAT MODEL OF STREPTOZOTOCIN-INDUCED DIABETES
    Authors:
    Karolina Siewiera, Magdalena Labieniec-Watala, Hassan Kassassir, Dawid Polak, Nina Wolska, & Cezary Watala
    Conference:
    1st Italian- UK Platelet Meeting (rok: 2017, ), Wydawca: Taylor and Francis
    Data:
    konferencja 7-8.09.2017
    Status:
    Published
  5. BLOOD PLATELETS' ADHESION TO ENDOTHELIUM IS INCREASED IN VIVO IN MICE WITH STREPTOZOTOCININDUCED DIABETES
    Authors:
    Tomasz Przygodzki, Marcin Talar, Hassan Kassassir, & Cezary Watala
    Conference:
    UK Platelet Meeting (rok: 2015, ), Wydawca: Taylor&Francis
    Data:
    konferencja 15-16 września
    Status:
    Published
    DOI:
    link to the publication
  6. Parameters of blood morphology and platelet activation undergo changes during progression of streptozotocininduced diabetes in rats
    Authors:
    K. Siewiera, H. Kassassir, T. Przygodzki, D. Polak, N. Wolska, M. Talar, C. Watala
    Conference:
    25th Krakow Conference on Endothelium (rok: 2017, ), Wydawca: Jagiellonian Centre for Experimental Therapeutics
    Data:
    konferencja 20-21 października
    Status:
    Published
  7. QUANTIFICATION OF BLOOD PLATELET REACTIVITY IN MODEL OF ADP-INDUCED NON-LETHAL PULMONARY THROMBOEMBOLISM IN MICE WITH THE USE OF LASER DOPPLER FLOWMETRY
    Authors:
    Tomasz Przygodzki , Marcin Talar , Agnieszka Blazejczyk , Vyacheslav Kalchenko , & Cezary Watala
    Conference:
    UK Platelet Meeting (rok: 2015, ), Wydawca: Taylor&Francis
    Data:
    konferencja 15-16 września
    Status:
    Published
    DOI:
    link to the publication
  8. NIEENZYMATYCZNE MODYFIKACJE PŁYTKOWEJ CYKLOOKSYGENAZY 1 – CZY GLIKACJA MOŻE ZMNIEJSZAĆ WRAŻLIWOŚC PŁYTEK KRWI NA DZIAŁANIE KWASU ACETYLOSALICYLOWEGO?
    Authors:
    Cezary Watala, Hassan Kassassir, Karolina Siewiera, Emilia Stec-Martyna, Zofia Pawłowska
    Conference:
    58 Zjazd Naukowy Polskiego Towarzystwa Chemicznego, Gdańsk (rok: 2015, ), Wydawca: Polskiego Towarzystwo Chemiczne
    Data:
    konferencja 21-25 listopada
    Status:
    Published
  9. DOES NON-ENZYMATIC GLYCOSYLATION INVOLVE PLATELET GLYCOPROTEIN IIBIIIA AND AFFECT RECEPTOR-LIGAND INTERACTION? – A PRELIMINARY STUDY
    Authors:
    M. Boncler , E. Stec-Martytna , & C. Watala
    Conference:
    UK Platelet Meeting (rok: 2015, ), Wydawca: Taylor&Francis
    Data:
    konferencja 15-16 września
    Status:
    Published
    DOI:
    link to the publication
  10. EVALUATION OF BLOOD PLATELET ADHESIVENESS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS UNDER FLOW CONDITIONS
    Authors:
    Tomasz Przygodzki, Boguslawa Luzak, Lidia Stanczyk, Marcin Kosmalski, Hassan Kassassir, Józef Drzewoski, Cezary Watala
    Conference:
    1st Italian- UK Platelet Meeting (rok: 2017, ), Wydawca: Taylor and Francis
    Data:
    konferencja 7-8.09.2017
    Status:
    Published

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