"RNA toxicity in pathogenesis of polyglutamine diseases"

2012/06/A/NZ1/00094

Keywords

Descriptors

  • NZ1_1: Biologia molekularna
  • NZ1_5: Inżynieria genetyczna
  • NZ1_7: Inżynieria komórkowa

Panel

NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution

Instytut Chemii Bioorganicznej PAN

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Maciej Figiel

Number of co-investigators in the project: 10

Call

MAESTRO 3 – announced on 2012-06-15

Amount awarded
2 996 500 PLN
Project start date
2013-03-22
Project end date
2019-03-21
Project duration
72 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Termocykler (2 szt) i aparat do hybrydyzacji "dot blot" z pompą.

Information in the final report

Publication in academic press/journals (21)

  1. 2D and 3D FISH of expanded repeat RNAs in human lymphoblasts

    Authors:
    Urbanek MO, Michalak M, Krzyzosiak WJ
    Academic press:
    Methods (year: 2017, volume: 120, pages: 49-57), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ymeth.2017.04.002 – link to the publication
  2. Modeling simple repeat expansion diseases with iPSC technology

    Authors:
    Jaworska E, Kozlowska E, Switonski PM, Krzyzosiak WJ
    Academic press:
    Cellular and Molecular Life Sciences (year: 2016, volume: 73, pages: 4085-4100), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-016-2284-0 – link to the publication
  3. Identifying proteins that bind to specific RNAs - focus on simple repeat expansion diseases

    Authors:
    Jazurek M, Ciesiolka A, Starega-Roslan J, Bilinska K, Krzyzosiak WJ
    Academic press:
    Nucleic Acids Research (year: 2016, volume: 44, pages: 9050-9070), Publisher: OXFORD ACADEMIC
    Status:
    Published
    DOI:
    10.1093/nar/gkw803 – link to the publication
  4. Reduction of Huntington's Disease RNA Foci by CAG Repeat-Targeting Reagents

    Authors:
    Urbanek MO, Fiszer A, Krzyzosiak WJ
    Academic press:
    Frontiers in Cellular Neuroscience (year: 2017, volume: 11, pages: 82), Publisher: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fncel.2017.00082 – link to the publication
  5. Generation of human iPS cell line IBCHi002-A from spinocerebellar ataxia type 3/Machado-Joseph disease patient's fibroblasts

    Authors:
    Agata Ciolak, Wlodzimierz J Krzyzosiak, Emilia Kozlowska, Agnieszka Fiszer
    Academic press:
    Stem Cell Research (year: 2020, volume: 45, pages: 101796), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.scr.2020.101796 – link to the publication
  6. RAN Translation of the Expanded CAG Repeats in the SCA3 Disease Context

    Authors:
    Magdalena Jazurek-Ciesiolka, Adam Ciesiolka, Alicja A.Komur, Martyna O.Urbanek-Trzeciak, Wlodzimierz J.Krzyzosiak, AgnieszkaFiszer
    Academic press:
    Journal of Molecular Biology (year: 2020, volume: 432, pages: 166699), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jmb.2020.10.033 – link to the publication
  7. miRNAmotif—A Tool for the Prediction of Pre-miRNA–Protein Interactions

    Authors:
    Urbanek-Trzeciak MO, Jaworska E, Krzyzosiak WJ
    Academic press:
    International Journal of Molecular Sciences (year: 2018, volume: 19, pages: 4075), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19124075 – link to the publication
  8. Structural Characteristics of Simple RNA Repeats Associated with Disease and their Deleterious Protein Interactions

    Authors:
    Ciesiolka A, Jazurek M, Drazkowska K, Krzyzosiak WJ
    Academic press:
    Frontiers in Cellular Neuroscience (year: 2017, volume: 11, pages: 97), Publisher: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fncel.2017.00097 – link to the publication
  9. Discriminating RNA variants with single-molecule allele-specific FISH

    Authors:
    Urbanek MO, Krzyzosiak WJ
    Academic press:
    Mutation Research. Reviews in Mutation Research (year: 2017, volume: 773, pages: 230-241), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mrrev.2016.09.003 – link to the publication
  10. Nuclear speckles: molecular organization, biological function and role in disease

    Authors:
    Galganski L, Urbanek MO, Krzyzosiak WJ
    Academic press:
    Nucleic Acids Research (year: 2017, volume: 45, pages: 10350-10368), Publisher: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkx759 – link to the publication
  11. Small RNA Detection by in Situ Hybridization Methods

    Authors:
    Urbanek MO, Nawrocka AU, Krzyzosiak WJ.
    Academic press:
    International Journal of Molecular Sciences (year: 2015, volume: 16(6), pages: 13259-13286), Publisher: MDPI AG
    Status:
    Published
    DOI:
    10.3390/ijms160613259 – link to the publication
  12. The role of the immune system in triplet repeat expansion diseases.

    Authors:
    Olejniczak M, Urbanek MO, Krzyzosiak WJ.
    Academic press:
    Mediators of Inflammation (year: 2015, volume: -, pages: 873860), Publisher: HINDAWI PUBLISHING CORPORATION
    Status:
    Published
    DOI:
    10.1155/2015/873860 – link to the publication
  13. Current understanding of the role of microRNAs in spinocerebellar ataxias

    Authors:
    Edyta Koscianska and Wlodzimierz J Krzyzosiak
    Academic press:
    Cerebellum and Ataxias (year: 2014, volume: 0,0465277777777778, pages: bd), Publisher: BioMed Central
    Status:
    Published
    DOI:
    10.1186/2053-8871-1-7 – link to the publication
  14. Sequence-non-specific effects generated by various types of RNA interference triggers

    Authors:
    Olejniczak M, Urbanek MO, Jaworska E, Witucki L, Szczesniak MW, Makalowska I, Krzyzosiak WJ.
    Academic press:
    Biochimica et Biophysica Acta (year: 2015, volume: 1859(2), pages: 306–314), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbagrm.2015.11.005 – link to the publication
  15. Cooperation meets competition in microRNA-mediated DMPK transcript regulation

    Authors:
    Koscianska E, Witkos TM, Kozlowska E, Wojciechowska M, Krzyzosiak WJ
    Academic press:
    Nucleic Acids Research (year: 2015, volume: 43, pages: 9500-9518), Publisher: OXFORD UNIV PRESS
    Status:
    Published
    DOI:
    10.1093/nar/gkv849 – link to the publication
  16. In Vitro Expansion of CAG, CAA, and Mixed CAG/CAA Repeats

    Authors:
    Figura G, Koscianska E, Krzyzosiak WJ.
    Academic press:
    International Journal of Molecular Sciences (year: 2015, volume: 16(8), pages: 18741-18751), Publisher: MDPI AG
    Status:
    Published
    DOI:
    10.3390/ijms160818741 – link to the publication
  17. Nuclear speckles are detention centers for transcripts containing expanded CAG repeats

    Authors:
    Urbanek MO, Jazurek M, Switonski PM, Figura G, Krzyzosiak WJ
    Academic press:
    Biochimica et Biophysica Acta - Molecular Basis of Disease (year: 2016, volume: 1862, pages: 1513-1520), Publisher: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2016.05.015 – link to the publication
  18. siRNA release from pri-miRNA scaffolds is controlled by the sequence and structure of RNA

    Authors:
    Galka-Marciniak P, Olejniczak M, Starega-Roslan J, Szczesniak MW, Makalowska I, Krzyzosiak WJ
    Academic press:
    Biochimica et Biophysica Acta - Gene Regulatory Mechanisms (year: 2016, volume: 1859, pages: 639-649), Publisher: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.bbagrm.2016.02.014 – link to the publication
  19. RNA FISH for detecting expanded repeats in human diseases

    Authors:
    Urbanek MO, Krzyzosiak WJ
    Academic press:
    Methods (year: 2015, volume: 2015, pages: S1046-2023), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ymeth.2015.11.017 – link to the publication
  20. RAN translation and frameshifting as translational challenges at simple repeats of human neurodegenerative disorders

    Authors:
    Wojciechowska M, Olejniczak M, Galka-Marciniak P, Jazurek M, Krzyzosiak WJ
    Academic press:
    Nucleic Acids Research (year: 2014, volume: 42(19), pages: 11849-64), Publisher: Oxford Univ Press
    Status:
    Published
    DOI:
    10.1093/nar/gku794 – link to the publication
  21. RNA imaging in living cells - methods and applications

    Authors:
    Urbanek MO, Galka-Marciniak P, Olejniczak M, Krzyzosiak WJ
    Academic press:
    RNA Biology (year: 2014, volume: 3;11(8), pages: 1083-95), Publisher: Landes Bioscience
    Status:
    Published
    DOI:
    10.4161/rna.35506 – link to the publication

Book publications / chapters in book publications (1)

  1. MicroRNA deregulation in trinucleotide repeat expansion disorders

    Authors:
    Koscianska E, Kozlowska E, Jaworska E, Krzyzosiak WJ.
    Book:
    Applied RNAi: From Fundamental Research to Therapeutic Applications (year: 2014, volume: bd, pages: 227-246), Publisher: Caister Academic Press
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski