"RNA toxicity in pathogenesis of polyglutamine diseases"
2012/06/A/NZ1/00094
Keywords
Descriptors
- NZ1_1: Biologia molekularna
- NZ1_5: Inżynieria genetyczna
- NZ1_7: Inżynieria komórkowa
Panel
NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution
Instytut Chemii Bioorganicznej PAN
Voivodeship: wielkopolskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 10
Call
MAESTRO 3 – announced on 2012-06-15
- Amount awarded
- 2 996 500 PLN
- Project start date
- 2013-03-22
- Project end date
- 2019-03-21
- Project duration
- 72 months (the same as in the proposal)
- Project status
- Project settled
Equipment purchased [PL]
- Termocykler (2 szt) i aparat do hybrydyzacji "dot blot" z pompą.
Information in the final report
Publication in academic press/journals (21)
-
2D and 3D FISH of expanded repeat RNAs in human lymphoblasts
- Authors:
- Urbanek MO, Michalak M, Krzyzosiak WJ
- Academic press:
- Methods (year: 2017, volume: 120, pages: 49-57), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.ymeth.2017.04.002 – link to the publication
-
Modeling simple repeat expansion diseases with iPSC technology
- Authors:
- Jaworska E, Kozlowska E, Switonski PM, Krzyzosiak WJ
- Academic press:
- Cellular and Molecular Life Sciences (year: 2016, volume: 73, pages: 4085-4100), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s00018-016-2284-0 – link to the publication
-
Identifying proteins that bind to specific RNAs - focus on simple repeat expansion diseases
- Authors:
- Jazurek M, Ciesiolka A, Starega-Roslan J, Bilinska K, Krzyzosiak WJ
- Academic press:
- Nucleic Acids Research (year: 2016, volume: 44, pages: 9050-9070), Publisher: OXFORD ACADEMIC
- Status:
- Published
- DOI:
- 10.1093/nar/gkw803 – link to the publication
-
Reduction of Huntington's Disease RNA Foci by CAG Repeat-Targeting Reagents
- Authors:
- Urbanek MO, Fiszer A, Krzyzosiak WJ
- Academic press:
- Frontiers in Cellular Neuroscience (year: 2017, volume: 11, pages: 82), Publisher: Frontiers Media SA
- Status:
- Published
- DOI:
- 10.3389/fncel.2017.00082 – link to the publication
-
Generation of human iPS cell line IBCHi002-A from spinocerebellar ataxia type 3/Machado-Joseph disease patient's fibroblasts
- Authors:
- Agata Ciolak, Wlodzimierz J Krzyzosiak, Emilia Kozlowska, Agnieszka Fiszer
- Academic press:
- Stem Cell Research (year: 2020, volume: 45, pages: 101796), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.scr.2020.101796 – link to the publication
-
RAN Translation of the Expanded CAG Repeats in the SCA3 Disease Context
- Authors:
- Magdalena Jazurek-Ciesiolka, Adam Ciesiolka, Alicja A.Komur, Martyna O.Urbanek-Trzeciak, Wlodzimierz J.Krzyzosiak, AgnieszkaFiszer
- Academic press:
- Journal of Molecular Biology (year: 2020, volume: 432, pages: 166699), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.jmb.2020.10.033 – link to the publication
-
miRNAmotif—A Tool for the Prediction of Pre-miRNA–Protein Interactions
- Authors:
- Urbanek-Trzeciak MO, Jaworska E, Krzyzosiak WJ
- Academic press:
- International Journal of Molecular Sciences (year: 2018, volume: 19, pages: 4075), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms19124075 – link to the publication
-
Structural Characteristics of Simple RNA Repeats Associated with Disease and their Deleterious Protein Interactions
- Authors:
- Ciesiolka A, Jazurek M, Drazkowska K, Krzyzosiak WJ
- Academic press:
- Frontiers in Cellular Neuroscience (year: 2017, volume: 11, pages: 97), Publisher: Frontiers Media SA
- Status:
- Published
- DOI:
- 10.3389/fncel.2017.00097 – link to the publication
-
Discriminating RNA variants with single-molecule allele-specific FISH
- Authors:
- Urbanek MO, Krzyzosiak WJ
- Academic press:
- Mutation Research. Reviews in Mutation Research (year: 2017, volume: 773, pages: 230-241), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.mrrev.2016.09.003 – link to the publication
-
Nuclear speckles: molecular organization, biological function and role in disease
- Authors:
- Galganski L, Urbanek MO, Krzyzosiak WJ
- Academic press:
- Nucleic Acids Research (year: 2017, volume: 45, pages: 10350-10368), Publisher: Oxford University Press
- Status:
- Published
- DOI:
- 10.1093/nar/gkx759 – link to the publication
-
Small RNA Detection by in Situ Hybridization Methods
- Authors:
- Urbanek MO, Nawrocka AU, Krzyzosiak WJ.
- Academic press:
- International Journal of Molecular Sciences (year: 2015, volume: 16(6), pages: 13259-13286), Publisher: MDPI AG
- Status:
- Published
- DOI:
- 10.3390/ijms160613259 – link to the publication
-
The role of the immune system in triplet repeat expansion diseases.
- Authors:
- Olejniczak M, Urbanek MO, Krzyzosiak WJ.
- Academic press:
- Mediators of Inflammation (year: 2015, volume: -, pages: 873860), Publisher: HINDAWI PUBLISHING CORPORATION
- Status:
- Published
- DOI:
- 10.1155/2015/873860 – link to the publication
-
Current understanding of the role of microRNAs in spinocerebellar ataxias
- Authors:
- Edyta Koscianska and Wlodzimierz J Krzyzosiak
- Academic press:
- Cerebellum and Ataxias (year: 2014, volume: 0,0465277777777778, pages: bd), Publisher: BioMed Central
- Status:
- Published
- DOI:
- 10.1186/2053-8871-1-7 – link to the publication
-
Sequence-non-specific effects generated by various types of RNA interference triggers
- Authors:
- Olejniczak M, Urbanek MO, Jaworska E, Witucki L, Szczesniak MW, Makalowska I, Krzyzosiak WJ.
- Academic press:
- Biochimica et Biophysica Acta (year: 2015, volume: 1859(2), pages: 306–314), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.bbagrm.2015.11.005 – link to the publication
-
Cooperation meets competition in microRNA-mediated DMPK transcript regulation
- Authors:
- Koscianska E, Witkos TM, Kozlowska E, Wojciechowska M, Krzyzosiak WJ
- Academic press:
- Nucleic Acids Research (year: 2015, volume: 43, pages: 9500-9518), Publisher: OXFORD UNIV PRESS
- Status:
- Published
- DOI:
- 10.1093/nar/gkv849 – link to the publication
-
In Vitro Expansion of CAG, CAA, and Mixed CAG/CAA Repeats
- Authors:
- Figura G, Koscianska E, Krzyzosiak WJ.
- Academic press:
- International Journal of Molecular Sciences (year: 2015, volume: 16(8), pages: 18741-18751), Publisher: MDPI AG
- Status:
- Published
- DOI:
- 10.3390/ijms160818741 – link to the publication
-
Nuclear speckles are detention centers for transcripts containing expanded CAG repeats
- Authors:
- Urbanek MO, Jazurek M, Switonski PM, Figura G, Krzyzosiak WJ
- Academic press:
- Biochimica et Biophysica Acta - Molecular Basis of Disease (year: 2016, volume: 1862, pages: 1513-1520), Publisher: ELSEVIER
- Status:
- Published
- DOI:
- 10.1016/j.bbadis.2016.05.015 – link to the publication
-
siRNA release from pri-miRNA scaffolds is controlled by the sequence and structure of RNA
- Authors:
- Galka-Marciniak P, Olejniczak M, Starega-Roslan J, Szczesniak MW, Makalowska I, Krzyzosiak WJ
- Academic press:
- Biochimica et Biophysica Acta - Gene Regulatory Mechanisms (year: 2016, volume: 1859, pages: 639-649), Publisher: ELSEVIER
- Status:
- Published
- DOI:
- 10.1016/j.bbagrm.2016.02.014 – link to the publication
-
RNA FISH for detecting expanded repeats in human diseases
- Authors:
- Urbanek MO, Krzyzosiak WJ
- Academic press:
- Methods (year: 2015, volume: 2015, pages: S1046-2023), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.ymeth.2015.11.017 – link to the publication
-
RAN translation and frameshifting as translational challenges at simple repeats of human neurodegenerative disorders
- Authors:
- Wojciechowska M, Olejniczak M, Galka-Marciniak P, Jazurek M, Krzyzosiak WJ
- Academic press:
- Nucleic Acids Research (year: 2014, volume: 42(19), pages: 11849-64), Publisher: Oxford Univ Press
- Status:
- Published
- DOI:
- 10.1093/nar/gku794 – link to the publication
-
RNA imaging in living cells - methods and applications
- Authors:
- Urbanek MO, Galka-Marciniak P, Olejniczak M, Krzyzosiak WJ
- Academic press:
- RNA Biology (year: 2014, volume: 3;11(8), pages: 1083-95), Publisher: Landes Bioscience
- Status:
- Published
- DOI:
- 10.4161/rna.35506 – link to the publication
Book publications / chapters in book publications (1)
-
MicroRNA deregulation in trinucleotide repeat expansion disorders
- Authors:
- Koscianska E, Kozlowska E, Jaworska E, Krzyzosiak WJ.
- Book:
- Applied RNAi: From Fundamental Research to Therapeutic Applications (year: 2014, volume: bd, pages: 227-246), Publisher: Caister Academic Press
- Status:
- Published