Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Molecular mechanisms of pro-survival processes in breast cancer

2012/06/A/NZ1/00089

Keywords:

mutations in TP53 and MDM2 genes chemoresistance DNA repair angiogenesis

Descriptors:

  • NZ1_1:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Maciej Żylicz 

Number of co-investigators in the project: 11

Call: MAESTRO 3 - announced on 2012-06-15

Amount awarded: 3 000 000 PLN

Project start date (Y-m-d): 2013-05-06

Project end date (Y-m-d): 2019-01-05

Project duration:: 68 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komputery z monitorami i oprogramowaniem (3 szt.) (30 000 PLN)
  2. Drukarka kolorowa laserowa (10 000 PLN)
  3. Inkubator CO2 (60 000 PLN)

Information in the final report

  • Publication in academic press/journals (10)
  1. Oncogenesis and induced pluripotency – commonalities of signalling pathways
    Authors:
    Marta Klimczk
    Academic press:
    Contemporary Oncology (rok: 2015, tom: 19, strony: A16-A21), Wydawca: Termedia Publishing House ul. Kleeberga 2 61-615 Poznań
    Status:
    Published
    DOI:
    10.5114/wo.2014.47133 - link to the publication
  2. Białka z rodziny ID w inicjacji i progresji nowotworów
    Authors:
    Magdalena Pruszko, Alicja Zylicz
    Academic press:
    Postępy Biochemii (rok: 2016, tom: Tom 62, Nr 4, strony: 449-458), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
  3. Molecular chaperones in the acquisition of cancer cell chemoresistance with mutated TP53 and MDM2 up-regulation
    Authors:
    Tracz-Gaszewska Z, Klimczak M, Biecek P, Herok M, Kosinski M, Olszewski MB, Czerwińska P, Wiech M, Wiznerowicz M, Zylicz A, Zylicz M, Wawrzynow B.
    Academic press:
    Oncotarget (rok: 2017, tom: 8(47), strony: 82123-82143.), Wydawca: Impact Journals, Mikhail Blagosklonny, Andrei V. Gudkov
    Status:
    Published
    DOI:
    10.18632/oncotarget.18899 - link to the publication
  4. Zebrafish as experimental model to establish the contribution of mutant p53 and ID4 to breast cancer angiogenesis in vivo
    Authors:
    Magdalena Pruszko, Elisa Milano, Alicja Zylicz, Maciej Zylicz, Giovanni Blandino, Giulia Fontemaggi
    Academic press:
    Journal of Thoracic Disease (rok: 2018, tom: 10(3), strony: E231-E233), Wydawca: AME Publishing Company
    Status:
    Published
    DOI:
    10.21037/jtd.2018.03.86 - link to the publication
  5. The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge
    Authors:
    Katarzyna Tomczak, Patrycja Czerwińska, Maciej Wiznerowicz
    Academic press:
    Contemporary Oncology (rok: 2015, tom: 19, strony: A68-A77), Wydawca: Termedia Publishing House ul. Kleeberga 2 61-615 Poznań
    Status:
    Published
    DOI:
    10.5114/wo.2014.47136 - link to the publication
  6. Chaperoning the guardian of the genome. The two-faced role of molecular chaperones in p53 tumor suppressor action
    Authors:
    Wawrzynow B, Zylicz A, Zylicz M
    Academic press:
    Biochim Biophys Acta, Rev Cancer (rok: 2018, tom: 1869(2), strony: 161-174), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.bbcan.2017.12.004 - link to the publication
  7. Diverse and cancer type‑specific roles of the p53 R248Q gain‑of‑function mutation in cancer migration and invasiveness
    Authors:
    Olszewski MB, Pruszko M, Snaar-Jagalska E, Zylicz A, Zylicz M
    Academic press:
    INTERNATIONAL JOURNAL OF ONCOLOGY (rok: 2019, tom: 54, strony: 1168-1182), Wydawca: Spandidos Publications, United Kingdom
    Status:
    Published
    DOI:
    10.3892/ijo.2019.4723 - link to the publication
  8. Heat shock proteins create a signature to predict the clinical outcome in breast cancer
    Authors:
    Klimczak M, Biecek P, Zylicz A, Zylicz M.
    Academic press:
    Scientific Reports (rok: 2019, ), Wydawca: Nature Research
    Status:
    Published
    DOI:
    10.1038/s41598-019-43556-1 - link to the publication
  9. Wild-type p53 oligomerizes more efficiently than p53 hot-spot mutants and overcomes mutant p53 gain-of-function via a dominant-positive mechanism
    Authors:
    Dawid Walerych, Magdalena Pruszko, Lukasz Zyla, Michalina Wezyk, Katarzyna Gaweda-Walerych and Alicja Zylicz
    Academic press:
    Oncotarget (rok: 2018, tom: 9(62), strony: 32063-32080), Wydawca: Impact Journals, LLC
    Status:
    Published
    DOI:
    10.18632/oncotarget.25944 - link to the publication
  10. Wielofunkcyjność białka MDM2 oraz jego rola w niestabilności genomowej komórek nowotworowych
    Authors:
    Marta Małuszek
    Academic press:
    Postępy Biochemii (rok: 2015, tom: 61, nr 1, strony: brak), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published