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Molecular mechanisms of pro-survival processes in breast cancer

2012/06/A/NZ1/00089

Keywords

Descriptors

  • NZ1_1: Biologia molekularna

Panel

NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Maciej Żylicz

Number of co-investigators in the project: 11

Call

MAESTRO 3 – announced on 2012-06-15

Amount awarded
3 000 000 PLN
Project start date
2013-05-06
Project end date
2019-01-05
Project duration
68 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Drukarka kolorowa laserowa. Cost: 10 000 PLN
  2. Inkubator CO2. Cost: 60 000 PLN
  3. Komputery z monitorami i oprogramowaniem (3 pcs). Cost: 30 000 PLN

Information in the final report

Publication in academic press/journals (12)

  1. Molecular chaperones in the acquisition of cancer cell chemoresistance with mutated TP53 and MDM2 up-regulation

    Authors:
    Tracz-Gaszewska Z, Klimczak M, Biecek P, Herok M, Kosinski M, Olszewski MB, Czerwińska P, Wiech M, Wiznerowicz M, Zylicz A, Zylicz M, Wawrzynow B.
    Academic press:
    Oncotarget (year: 2017, volume: 8(47), pages: 82123-82143.), Publisher: Impact Journals, Mikhail Blagosklonny, Andrei V. Gudkov
    Status:
    Published
    DOI:
    10.18632/oncotarget.18899 – link to the publication

  2. The mutant p53-ID4 complex controls VEGFA isoforms by recruiting lncRNA MALAT1

    Authors:
    Pruszko M, Milano E, Forcato M, Donzelli S, Ganci F, Di Agostino S, De Panfilis S, Fazi F, Bates DO, Bicciato S, Zylicz M, Zylicz A, Blandino G, Fontemaggi G.
    Academic press:
    EMBO Reports (year: 2017, volume: 18(8), pages: 1331-1351), Publisher: EMBO Press
    Status:
    Published
    DOI:
    10.15252/embr.201643370 – link to the publication

  3. Białka z rodziny ID w inicjacji i progresji nowotworów

    Authors:
    Magdalena Pruszko, Alicja Zylicz
    Academic press:
    Postępy Biochemii (year: 2016, volume: Tom 62, Nr 4, pages: 449-458), Publisher: Polskie Towarzystwo Biochemiczne
    Status:
    Published

  4. Oncogenesis and induced pluripotency – commonalities of signalling pathways

    Authors:
    Marta Klimczk
    Academic press:
    Contemporary Oncology (year: 2015, volume: 19, pages: A16-A21), Publisher: Termedia Publishing House ul. Kleeberga 2 61-615 Poznań
    Status:
    Published
    DOI:
    10.5114/wo.2014.47133 – link to the publication

  5. Wielofunkcyjność białka MDM2 oraz jego rola w niestabilności genomowej komórek nowotworowych

    Authors:
    Marta Małuszek
    Academic press:
    Postępy Biochemii (year: 2015, volume: 61, nr 1, pages: brak), Publisher: Polskie Towarzystwo Biochemiczne
    Status:
    Published

  6. Diverse and cancer type‑specific roles of the p53 R248Q gain‑of‑function mutation in cancer migration and invasiveness

    Authors:
    Olszewski MB, Pruszko M, Snaar-Jagalska E, Zylicz A, Zylicz M
    Academic press:
    INTERNATIONAL JOURNAL OF ONCOLOGY (year: 2019, volume: 54, pages: 1168-1182), Publisher: Spandidos Publications, United Kingdom
    Status:
    Published
    DOI:
    10.3892/ijo.2019.4723 – link to the publication

  7. Wild-type p53 oligomerizes more efficiently than p53 hot-spot mutants and overcomes mutant p53 gain-of-function via a dominant-positive mechanism

    Authors:
    Dawid Walerych, Magdalena Pruszko, Lukasz Zyla, Michalina Wezyk, Katarzyna Gaweda-Walerych and Alicja Zylicz
    Academic press:
    Oncotarget (year: 2018, volume: 9(62), pages: 32063-32080), Publisher: Impact Journals, LLC
    Status:
    Published
    DOI:
    10.18632/oncotarget.25944 – link to the publication

  8. Expression of ID4 protein in breast cancer cells induces reprogramming of tumourassociated macrophages

    Authors:
    Sara Donzelli, Elisa Milano, Magdalena Pruszko, Andrea Sacconi, Silvia Masciarelli, Ilaria Iosue, Elisa Melucci, Enzo Gallo, Irene Terrenato, Marcella Mottolese, Maciej Zylicz, Alicja Zylicz, Francesco Fazi, Giovanni Blandino and Giulia Fontemaggi
    Academic press:
    Breast Cancer Research (year: 2018, volume: 0,874305555555556, pages: 46037), Publisher: BIOMED CENTRAL LTD
    Status:
    Published
    DOI:
    10.1186/s13058-018-0990-2 – link to the publication

  9. Chaperoning the guardian of the genome. The two-faced role of molecular chaperones in p53 tumor suppressor action

    Authors:
    Wawrzynow B, Zylicz A, Zylicz M
    Academic press:
    Biochim Biophys Acta, Rev Cancer (year: 2018, volume: 1869(2), pages: 161-174), Publisher: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.bbcan.2017.12.004 – link to the publication

  10. Zebrafish as experimental model to establish the contribution of mutant p53 and ID4 to breast cancer angiogenesis in vivo

    Authors:
    Magdalena Pruszko, Elisa Milano, Alicja Zylicz, Maciej Zylicz, Giovanni Blandino, Giulia Fontemaggi
    Academic press:
    Journal of Thoracic Disease (year: 2018, volume: 10(3), pages: E231-E233), Publisher: AME Publishing Company
    Status:
    Published
    DOI:
    10.21037/jtd.2018.03.86 – link to the publication

  11. The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge

    Authors:
    Katarzyna Tomczak, Patrycja Czerwińska, Maciej Wiznerowicz
    Academic press:
    Contemporary Oncology (year: 2015, volume: 19, pages: A68-A77), Publisher: Termedia Publishing House ul. Kleeberga 2 61-615 Poznań
    Status:
    Published
    DOI:
    10.5114/wo.2014.47136 – link to the publication

  12. Heat shock proteins create a signature to predict the clinical outcome in breast cancer

    Authors:
    Klimczak M, Biecek P, Zylicz A, Zylicz M.
    Academic press:
    Scientific Reports (year: 2019, volume: 0, pages: 0), Publisher: Nature Research
    Status:
    Published
    DOI:
    10.1038/s41598-019-43556-1 – link to the publication

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