Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Molecular mechanisms of pro-survival processes in breast cancer

2012/06/A/NZ1/00089

Keywords:

mutations in TP53 and MDM2 genes chemoresistance DNA repair angiogenesis

Descriptors:

  • NZ1_1: Molecular biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Maciej Żylicz 

Number of co-investigators in the project: 11

Call: MAESTRO 3 - announced on 2012-06-15

Amount awarded: 3 000 000 PLN

Project start date (Y-m-d): 2013-05-06

Project end date (Y-m-d): 2019-01-05

Project duration:: 68 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komputery z monitorami i oprogramowaniem (3 szt.) (30 000 PLN)
  2. Drukarka kolorowa laserowa (10 000 PLN)
  3. Inkubator CO2 (60 000 PLN)

Information in the final report

  • Publication in academic press/journals (12)
  1. Diverse and cancer type‑specific roles of the p53 R248Q gain‑of‑function mutation in cancer migration and invasiveness
    Authors:
    Olszewski MB, Pruszko M, Snaar-Jagalska E, Zylicz A, Zylicz M
    Academic press:
    INTERNATIONAL JOURNAL OF ONCOLOGY (rok: 2019, tom: 54, strony: 1168-1182), Wydawca: Spandidos Publications, United Kingdom
    Status:
    Published
    DOI:
    10.3892/ijo.2019.4723 - link to the publication
  2. Molecular chaperones in the acquisition of cancer cell chemoresistance with mutated TP53 and MDM2 up-regulation
    Authors:
    Tracz-Gaszewska Z, Klimczak M, Biecek P, Herok M, Kosinski M, Olszewski MB, Czerwińska P, Wiech M, Wiznerowicz M, Zylicz A, Zylicz M, Wawrzynow B.
    Academic press:
    Oncotarget (rok: 2017, tom: 8(47), strony: 82123-82143.), Wydawca: Impact Journals, Mikhail Blagosklonny, Andrei V. Gudkov
    Status:
    Published
    DOI:
    10.18632/oncotarget.18899 - link to the publication
  3. Oncogenesis and induced pluripotency – commonalities of signalling pathways
    Authors:
    Marta Klimczk
    Academic press:
    Contemporary Oncology (rok: 2015, tom: 19, strony: A16-A21), Wydawca: Termedia Publishing House ul. Kleeberga 2 61-615 Poznań
    Status:
    Published
    DOI:
    10.5114/wo.2014.47133 - link to the publication
  4. Expression of ID4 protein in breast cancer cells induces reprogramming of tumourassociated macrophages
    Authors:
    Sara Donzelli, Elisa Milano, Magdalena Pruszko, Andrea Sacconi, Silvia Masciarelli, Ilaria Iosue, Elisa Melucci, Enzo Gallo, Irene Terrenato, Marcella Mottolese, Maciej Zylicz, Alicja Zylicz, Francesco Fazi, Giovanni Blandino and Giulia Fontemaggi
    Academic press:
    Breast Cancer Research (rok: 2018, tom: 0,874305555555556, strony: 45306), Wydawca: BIOMED CENTRAL LTD
    Status:
    Published
    DOI:
    10.1186/s13058-018-0990-2 - link to the publication
  5. Wielofunkcyjność białka MDM2 oraz jego rola w niestabilności genomowej komórek nowotworowych
    Authors:
    Marta Małuszek
    Academic press:
    Postępy Biochemii (rok: 2015, tom: 61, nr 1, strony: brak), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    brak - link to the publication
  6. Chaperoning the guardian of the genome. The two-faced role of molecular chaperones in p53 tumor suppressor action
    Authors:
    Wawrzynow B, Zylicz A, Zylicz M
    Academic press:
    Biochim Biophys Acta, Rev Cancer (rok: 2018, tom: 1869(2), strony: 161-174), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.bbcan.2017.12.004 - link to the publication
  7. Heat shock proteins create a signature to predict the clinical outcome in breast cancer
    Authors:
    Klimczak M, Biecek P, Zylicz A, Zylicz M.
    Academic press:
    Scientific Reports (rok: 2019, ), Wydawca: Nature Research
    Status:
    Published
    DOI:
    10.1038/s41598-019-43556-1 - link to the publication
  8. The mutant p53-ID4 complex controls VEGFA isoforms by recruiting lncRNA MALAT1
    Authors:
    Pruszko M, Milano E, Forcato M, Donzelli S, Ganci F, Di Agostino S, De Panfilis S, Fazi F, Bates DO, Bicciato S, Zylicz M, Zylicz A, Blandino G, Fontemaggi G.
    Academic press:
    EMBO Reports (rok: 2017, tom: 18(8), strony: 1331-1351), Wydawca: EMBO Press
    Status:
    Published
    DOI:
    10.15252/embr.201643370 - link to the publication
  9. Białka z rodziny ID w inicjacji i progresji nowotworów
    Authors:
    Magdalena Pruszko, Alicja Zylicz
    Academic press:
    Postępy Biochemii (rok: 2016, tom: Tom 62, Nr 4, strony: 449-458), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    brak - link to the publication
  10. The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge
    Authors:
    Katarzyna Tomczak, Patrycja Czerwińska, Maciej Wiznerowicz
    Academic press:
    Contemporary Oncology (rok: 2015, tom: 19, strony: A68-A77), Wydawca: Termedia Publishing House ul. Kleeberga 2 61-615 Poznań
    Status:
    Published
    DOI:
    10.5114/wo.2014.47136 - link to the publication
  11. Wild-type p53 oligomerizes more efficiently than p53 hot-spot mutants and overcomes mutant p53 gain-of-function via a dominant-positive" mechanism
    Authors:
    Dawid Walerych, Magdalena Pruszko, Lukasz Zyla, Michalina Wezyk, Katarzyna Gaweda-Walerych and Alicja Zylicz
    Academic press:
    Oncotarget (rok: 2018, tom: 9(62), strony: 32063-32080), Wydawca: Impact Journals, LLC
    Status:
    Published
    DOI:
    10.18632/oncotarget.25944 - link to the publication
  12. Zebrafish as experimental model to establish the contribution of mutant p53 and ID4 to breast cancer angiogenesis in vivo
    Authors:
    Magdalena Pruszko, Elisa Milano, Alicja Zylicz, Maciej Zylicz, Giovanni Blandino, Giulia Fontemaggi
    Academic press:
    Journal of Thoracic Disease (rok: 2018, tom: 10(3), strony: E231-E233), Wydawca: AME Publishing Company
    Status:
    Published
    DOI:
    10.21037/jtd.2018.03.86 - link to the publication

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