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Interactions between polymorphic variants of CD28, CTLA-4, CD80, CD86, CBLB, CD40, CD40L and ALCAM genes as a predisposing factor to susceptibility to multiple sclerosis and clinical course of the disease.

2012/05/N/NZ6/03426

Keywords:

multiple sclerosis polymorphism gene-gene interactions

Descriptors:

  • NZ6_2: Clinical immunology
  • NZ2_6: Immunogenetics
  • NZ5_1: Etiology of human diseases

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda PAN

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Marta Wagner 

Number of co-investigators in the project: 2

Call: PRELUDIUM 3 - announced on 2012-03-15

Amount awarded: 100 000 PLN

Project start date (Y-m-d): 2013-02-13

Project end date (Y-m-d): 2015-02-12

Project duration:: 24 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (4)
  1. Investigation of gene–gene interactions between CD40 and CD40L in Polish multiple sclerosis patients
    Authors:
    M. Wagner, A. Wiśniewski, M. Bilińska, A. Pokryszko-Dragan, M. Cyrul, P. Kuśnierczyk, M. Jasek
    Academic press:
    Human Immunology (rok: 2014, tom: 75, strony: 796-801), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.humimm.2014.05.013 - link to the publication
  2. Polymorphisms in CD28, CTLA-4, CD80 and CD86 genes may influence the risk of multiple sclerosis and its age of onset
    Authors:
    Wagner M, Sobczyński M, Karabon L, Bilińska M, Pokryszko-Dragan A, Pawlak-Adamska E, Cyrul M, Kuśnierczyk P, Jasek M.
    Academic press:
    Jorunal of Neuroimmunology (rok: 2015, tom: 288, strony: 79-86), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jneuroim.2015.09.004 - link to the publication
  3. ALCAM and CD6-multiple sclerosis risk factors
    Authors:
    M. Wagner, M. Bilińska, A. Pokryszko-Dragan, M. Sobczyński, M. Cyru, P. Kuśnierczyk, M. Jasek
    Academic press:
    Journal of Neuroimmunology (rok: 2014, tom: 276, strony: 98-103), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jneuroim.2014.08.621 - link to the publication
  4. MS risk allele rs1883832T is associated with decreased mRNA expression of CD40
    Authors:
    Marta Wagner, Maciej Sobczyński, Małgorzata Bilińska, Anna Pokryszko-Dragan, Małgorzata Cyrul, Piotr Kuśnierczyk, Monika Jasek
    Academic press:
    Journal of Molecular Neuroscience (rok: 2015, tom: brak, strony: brak), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12031-015-0490-0 - link to the publication

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