Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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mRNA stabilization-dependent regulation of MMP-9 (Matrix Metalloproteinase-9) mRNA expression after the neuronal activation and during epileptogenesis

2012/05/B/NZ3/01943

Keywords:

MMP-9 mRNA stability epilepsy hippocampus

Descriptors:

  • NZ3_5: Molecular neurobiology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Centrum Medyczne Kształcenia Podyplomowego

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Marcin Rylski 

Number of co-investigators in the project: 5

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 469 000 PLN

Project start date (Y-m-d): 2013-02-13

Project end date (Y-m-d): 2017-02-12

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Uniwersalna rotoro-wytrząsarka Roto-Shake Genie(R) - 6-in-1, wraz z dodatkowym zestawem statywów na probówki Roto-Shake Genie, 230VAC; 71834-20; 6 Clip Plates for 12 each of 10-13mm tubes; 71834-50 (8 000 PLN)
  2. Aparat do elektroforezy horyzontalnej firmy Bio-Rad wraz z akcesoriami.
  3. mikroskop stereoskopowy Carl Zeiss, DV4 (6 000 PLN)

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (2)
  1. HuR (Elavl1) and HuB (Elavl2) Stabilize Matrix Metalloproteinase-9 mRNA During Seizure-Induced Mmp-9 Expression in Neurons
    Authors:
    Katarzyna Zybura-Broda, Malgorzata Wolder-Gontarek, Magdalena Ambrozek-Latecka, Artur Choros, Agnieszka Bogusz, Joanna Wilemska-Dziaduszycka and Marcin Rylski
    Academic press:
    Frontiers in Neuroscience (rok: 2018, tom: Volume 12, strony: Article 224), Wydawca: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fnins.2018.00224 - link to the publication
  1. Increased mRNA stability is a mechanism controlling Matrix Metalloproteinase-9 upregulation during epileptogenesis in the rat hippocampus
    Authors:
    Małgorzata Wolder-Gontarek, Katarzyna Zybura-Broda, Agnieszka Bogusz, Marcin Rylski
    Conference:
    Neuronus 2014 IBRO & IRUN Neuroscience Forum (rok: 2014, ), Wydawca: www.neuronusforum.pl
    Data:
    konferencja 25-27 kwietnia
    Status:
    Published
  2. MRNA STABILITY-DEPENDENT REGULATION OF MMP-9 (MATRIX METALLOPROTEINASE-9) EXPRESSION AFTER NEURONAL ACTIVATION IN THE RAT HIPPOCAMPUS
    Authors:
    K. Zybura-Broda, M. Ambrozek-Latecka, M. Wolder-Gontarek, J. Wilemska, M. Rylski
    Conference:
    9th Fens Forum of Neuroscience 2014, Milan, Italy (rok: 2014, ), Wydawca: Federation of European Neuroscience Societies
    Data:
    konferencja 05-09 lipca
    Status:
    Published

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