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Does overexpression of cell adhesion molecule L1 in rats with complete spinal cord transection influences the expression of ADAM10 metalloprotease and generation of soluble forms of L1.

2012/05/N/NZ4/02241

Keywords:

spinal cord injury cell adhesion molecules ADAM metaloproteases neuronal plasticity

Descriptors:

  • NZ4_9: Systems neurobiology
  • NZ4_10: Neuroimaging and computational neuroscience

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Rafał Płatek 

Number of co-investigators in the project: 3

Call: PRELUDIUM 3 - announced on 2012-03-15

Amount awarded: 100 000 PLN

Project start date (Y-m-d): 2013-01-25

Project end date (Y-m-d): 2015-01-24

Project duration:: 24 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (1)
  1. L1 overexpression in rats with complete spinal cord transection downregulates phosphacan and upregulates synaptophysin, GAP43 and Adcy1 expression
    Authors:
    Płatek R., Grycz K., Więckowska A., Czarkowska-Bauch J., Kügler S., Schachner M., Skup M.
    Academic press:
    Acta Neurobiologiae Experimentalis (rok: 2013, tom: 73 (Supl. 1), strony: 34-35), Wydawca: Nencki Institute of Experimental Biology Polish Neuroscience Society
    Status:
    Published
    DOI:
    "brak" - link to the publication
  2. The impact of training and neurotrophins on functional recovery after complete spinal cord transection: cellular and molecular mechanisms contributing to motor improvement
    Authors:
    Małgorzata Skup*, Ewelina Ziemlińska, Olga Gajewska-Woźniak, Rafał Płatek, Anna Maciejewska, and Julita Czarkowska-Bauch
    Academic press:
    Acta Neurobiologiae Experimentalis (rok: 2014, tom: 74, strony: 121-141), Wydawca: Nencki Institute of Experimental Biology Polish Neuroscience Society
    Status:
    Published
    DOI:
    brak - link to the publication
  1. Chronic L1 overexpression causes widespread changes in expression of molecules engaged in neuronal plasticity Adcy1, GAP-43 and synaptophysin, but not in ADAM10 - L1 shedding metalloprotease in rats with complete spinal cord transection
    Authors:
    Płatek R., Więckowska A., Grycz K., Czarkowska-Bauch J., Kügler S., Skup M.
    Conference:
    2014 Annual Meeting of Society for Neuroscience (rok: 2014, ), Wydawca: Society for Neuroscience
    Data:
    konferencja 15-19 listopada
    Status:
    Published
    DOI:
    link to the publication

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