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Design, synthesis and biological evaluation of novel functionalized batracylin conjugates

2012/05/B/NZ7/02461

Keywords

Descriptors

  • ST5_16: Chemia biologiczna
  • NZ7_14: Farmacja, farmakoterapia, farmakologia
  • ST5_23: Chemia organiczna

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Politechnika Gdańska, Wydział Chemiczny

Voivodeship: pomorskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Krystyna Jolanta Dzierzbicka

Number of co-investigators in the project: 5

Call

OPUS 3 – announced on 2012-03-15

Amount awarded
394 900 PLN
Project start date
2013-02-11
Project end date
2016-02-10
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Kamera cyfrowa z oprogramowaniem do akwizycji obrazu. Cost: 40 000 PLN

Information in the final report

Publication in academic press/journals (3)

  1. Erratum to Synthesis of functionalized new conjugates of batracylin with tuftsin/retro-tuftsin derivatives and their biological evaluation [Eur. J. Med. Chem. 106 (2015) 85e94]

    Authors:
    Wioleta Januchta, Marcin Serocki, Krystyna Dzierzbicka, Grzegorz Cholewiński, Andrzej Skladanowski
    Academic press:
    Eur. J. Med. Chem. (year: 2016, volume: 116, pages: 318-319), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2016.02.067 – link to the publication

  2. Synthesis and biological evaluation of novel analogues of batracylin with synthetic amino acids and adenosine: an unexpected effect on centromere segregation in tumor cells through a dual inhibition of topoisomerase II and Aurora B

    Authors:
    Wioleta Januchta, Marcin Serocki, Krystyna Dzierzbicka, Grzegorz Cholewinski, Monika Gensicka, Andrzej Skladanowski
    Academic press:
    RSC Advances (year: 2016, volume: 0, pages: 0), Publisher: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c6ra04957e – link to the publication

  3. Synthesis of functionalized new conjugates of batracylin with tuftsin/retro-tuftsin derivatives and their biological evaluation.

    Authors:
    Januchta W., Serocki M., Dzierzbicka K., Cholewiński G., Skladanowski A.
    Academic press:
    Eur. J. Med. Chem. (year: 2015, volume: 106, pages: 85-94), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2015.10.012 – link to the publication

Articles in post-conference publications (7)

  1. Synteza Amidowych pochodnych batracyliny

    Authors:
    W. Januchta, M. Gensicka, G. Cholewiński, K. Dzierzbicka
    Conference:
    57 Zjazd Naukowy Polskiego Towarzystwa Chemicznego i Stowarzyszenia Inżynierów i Techników Przemysłu Chemicznego (year: 2014, pages: 218), Publisher: Polskie Towarzystwo Chemiczne
    Date:
    conference 14-18 września, Częstochowa
    Status:
    Published

  2. Synteza nowych analogów batracyliny jako potencjalnych związków przeciwnowotworowych

    Authors:
    W. Januchta, K. Dzierzbicka, M. Serocki, G. Cholewiński, A. Składanowski
    Conference:
    57 Zjazd Naukowy Polskiego Towarzystwa Chemicznego i Stowarzyszenia Inżynierów i Techników Przemysłu Chemicznego (year: 2014, pages: 218), Publisher: Polskie Towarzystwo Chemiczne
    Date:
    conference 14-18 września Częstochowa
    Status:
    Published

  3. Synthesis and biological evaluation of functionalized derivatives of batracylin as new antitumor agents

    Authors:
    Serocki M., Januchta W., Dzierzbicka K., Składanowski A
    Conference:
    35th EORTC-PAMM Winter Meeting (year: 2014, pages: 41), Publisher: University of Münster, Germany
    Date:
    conference 12-15 February
    Status:
    Published

  4. Design and synthesis of new analogues of batracylin linked to tuftsin and retro-tuftsin derivatives

    Authors:
    W. Januchta, K. Dzierzbicka, G. Cholewiński, A. Składanowski, M. Serocki
    Conference:
    33RD European Peptide Symposium (year: 2014, pages: S161-S162), Publisher: John Wiley & Sons, Ltd
    Date:
    conference 31 August - 5 September Sofia, Bulgaria
    Status:
    Published

  5. Synthesis and cytotoxic activity of conjugates of adenosine with batracylin derivatives.

    Authors:
    W. Januchta, M. Serocki, M. Prejs, K. Dzierzbicka, G. Cholewinski, A. Skladanowski
    Conference:
    16th Tetrahedron Symposium (year: 2015, pages: P2.124), Publisher: Elsevier
    Date:
    conference 16-19 June
    Status:
    Published

  6. Novel functionalized conjugates of batracylin with aminoacids and short peptides as new antitumor agents,

    Authors:
    Serocki M., Januchta W., Cholewiński G., Dzierzbicka K., Składanowski A.
    Conference:
    36th EORTC-PAMM Winter Meeting (year: 2015, pages: 84), Publisher: Marseille Provence Métropole
    Date:
    conference 21-24 January
    Status:
    Published

  7. Synteza i badania biologiczne analogów batracyliny o potencjalnych właściwościach przeciwnowotworowych

    Authors:
    Januchta W., Dzierzbicka K., Serocki M., Cholewiński G., Składanowski A.
    Conference:
    58 Zjazd Naukowy PTChem (year: 2015, pages: 113), Publisher: Polskie Towarzystwo Chemiczne
    Date:
    conference 21-25 września
    Status:
    Published

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