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Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The role of corticotropin releasing factor (CRF) in low and high anxiety rats, and teh iteraction between of the CRF system and the inhibitory neurotransmitter (GABA) in modulation of anxiety reactions

2012/05/B/NZ7/02460

Keywords:

CRF system GABA sytem individual differences conditioned fear

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Psychiatrii i Neurologii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Anna Skórzewska 

Number of co-investigators in the project: 5

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 463 567 PLN

Project start date (Y-m-d): 2013-01-31

Project end date (Y-m-d): 2016-07-30

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komputer Lenovo Think Centre M83.
  2. Homogenizator ultradźwiękowy SONOPULS mini20 (14 000 PLN)
  3. Pompa dwutłokowa LC-20AD (32 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (2)
  1. Behavioral effects and CRF expression in brain structures of high- and low-anxiety rats after chronic restraint stress.
    Authors:
    Wisłowska-Stanek A, Lehner M, Skórzewska A, Krząścik P, Płaźnik A.
    Academic press:
    Behav Brain Res (rok: 2016, tom: 310, strony: 26-35), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbr.2016.05.001 - link to the publication
  2. Chronic restraint increases apoptosis in the hippocampus of rats with high responsiveness to fear stimuli
    Authors:
    Małgorzata Lehner, Aleksandra Wisłowska-Stanek, Anna Skórzewska, Adam Płaźnik
    Academic press:
    Neurosci. Lett. (rok: 2015, tom: 586, strony: 55-59), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neulet.2014.12.011 - link to the publication
  3. Midazolam treatment before re-exposure to contextual fear reduces freezing behavior and amygdala activity differentially in high- and low-anxiety rats.
    Authors:
    Skórzewska A, Lehner M, Wisłowska-Stanek A, Turzyńska D, Sobolewska A, Krząścik P, Płaźnik A.
    Academic press:
    Pharmacol Biochem Behav. (rok: 2015, tom: 129, strony: 34-44), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pbb.2014.11.020. - link to the publication
  4. The effect of chronic administration of corticosterone on anxiety- and depression-like behavior and the expression of GABA-A receptor alpha-2 subunits in brain structures of low- and high-anxiety rats.
    Authors:
    Skórzewska A, Lehner M, Wisłowska-Stanek A, Krząścik P, Ziemba A, Płaźnik A.
    Academic press:
    Horm Behav. (rok: 2014, tom: 65, strony: 45456), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.011 - link to the publication
  5. Changes in the brain expression of alpha-2 subunits of the GABA-A receptor after chronic restraint stress in low- and high-anxiety rats.
    Authors:
    Wisłowska-Stanek A, Lehner M, Skórzewska A, Krząścik P, Maciejak P, Szyndler J, Ziemba A, Płaźnik A.
    Academic press:
    Behav Brain Res (rok: 2013, tom: 253, strony: 337-45), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbr.2013.07.042. - link to the publication
  6. GABAergic control of the activity of the central nucleus of the amygdala in low- and high-anxiety rats
    Authors:
    Anna Skórzewska, Małgorzata Lehner, Aleksandra Wisłowska-Stanek, Danuta Turzyńska, Alicja Sobolewska, Paweł Krząścik, Adam Płaźnik
    Academic press:
    Neuropharmacology (rok: 2015, tom: 99, strony: 566-576), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuropharm.2015.08.039 - link to the publication
  1. Changes in the CRF expression after chronic restraint stress in high (HR) and low (LR) anxiety rats
    Authors:
    Aleksandra Wisłowska-Stanek, Małgorzata Lehner, Anna Skórzewska, Paweł Krząścik, Adam Płaźnik
    Conference:
    XIX International Congress of the Polish Pharmacological Society, Świnoujście, (rok: 2015, ), Wydawca: Pharmacological Reports
    Data:
    konferencja 17-19 September 2015
    Status:
    Published
    DOI:
    link to the publication
  2. The influence of chronic corticosterone administration on rat fear responses and amygdala activity in the high- and low- anxiety rats: The effect of midazolam
    Authors:
    Anna Skórzewska, Małgorzata Lehner, Aleksandra Wisłowska-Stanek, Danuta Turzyńska, Alicja Sobolewska, Paweł Krząścik, Adam Płaźnik
    Conference:
    XIX International Congress of the Polish Pharmacological Society, Świnoujście (rok: 2015, ), Wydawca: Pharmacological Reports
    Data:
    konferencja 17-19 September 2015
    Status:
    Published
    DOI:
    link to the publication

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