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Information on the principal investigator and host institution

Information of the project and the call

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The synthesis of new optically active aziridine alcohols and their application in asymmetric synthesis.

2012/05/D/ST5/00505

Keywords:

Aziridines aziridine alcohols ligands stereocontrolled synthesis

Descriptors:

  • ST5_18:
  • ST5_23:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Łódzki, Wydział Chemii, Katedra Chemii Organicznej i Stosowanej

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Michał Rachwalski 

Number of co-investigators in the project: 4

Call: SONATA 3 - announced on 2012-03-15

Amount awarded: 273 500 PLN

Project start date (Y-m-d): 2013-02-04

Project end date (Y-m-d): 2016-02-03

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Kolumna HPLC - semipreparatywna (cena z VAT) (16 605 PLN)
  2. Łaźnia ultradźwiękowa (cena z VAT) (4 000 PLN)
  3. Aparat do pomiaru temperatury topnienia (cena z VAT) (7 000 PLN)
  4. Chiralna kolumna HPLC - analityczna (cena z VAT) (10 000 PLN)
  5. Komputer typu Laptop Toshiba (4 300 PLN)
  6. Mieszadło magnetyczne z termometrem kontaktowym (cena z VAT) (4 000 PLN)
  7. Wyparka próżniowa + pompa membranowa (cena z VAT) (25 000 PLN)
  8. Zestaw do chromatografii fleszowej (cena z VAT) (3 600 PLN)
  9. Zestaw komputerowy PC z oprogramowaniem (cena z VAT) (2 szt.) (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (10)
  1. Highly enantioselective addition of arylzinc reagents to aldehydes promoted by chiral aziridine alcohols
    Authors:
    Z. Wujkowska, S. Jarzyński, A. M. Pieczonka, S. Leśniak, M. Rachwalski
    Academic press:
    Tetrahedron: Asymmetry (rok: 2016, tom: 27, strony: 1238 - 1244), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.005 - link to the publication
  2. Aziridine ring-containing chiral ligands as highly efficient catalysts in asymmetric synthesis
    Authors:
    M. Rachwalski, S. Jarzyński, S. Leśniak
    Academic press:
    Tetrahedron: Asymmetry (rok: 2013, tom: 24, strony: 421-425), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tetasy.2013.03.001 - link to the publication
  3. Mandelic acid derived alpha-aziridinyl alcohols as highly efficient ligands for asymmetric additions of zinc organyls to aldehydes
    Authors:
    M. Rachwalski, S. Jarzyński, M. Jasiński, S. Leśniak
    Academic press:
    Tetrahedron: Asymmetry (rok: 2013, tom: 24, strony: 689-693), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tetasy.2013.04.019 - link to the publication
  4. Highly enantioselective asymmetric direct aldol reaction promoted by aziridine amides constructed on chiral terpene scaffold
    Authors:
    Z. Wujkowska, A. Strojewska, A. M. Pieczonka, S. Leśniak, M. Rachwalski
    Academic press:
    Chirality (rok: 2017, tom: 29, strony: 213 - 220), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/chir.22698 - link to the publication
  5. Limonene oxide derived aziridinyl alcohols as highly efficient catalysts for asymmetric additions of organozinc species to aldehydes
    Authors:
    M. Rachwalski
    Academic press:
    Tetrahedron: Asymmetry (rok: 2014, tom: 25, strony: 219-223), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tetasy.2013.11.011 - link to the publication
  6. N-Trityl-aziridinyl alcohols as highly efficient chiral catalysts in asymmetric additions of organozinc species to aldehydes
    Authors:
    S. Jarzyński, S. Leśniak, A. M. Pieczonka, M. Rachwalski
    Academic press:
    Tetrahedron: Asymmetry (rok: 2015, tom: 26, strony: 35 - 40), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tetasy.2014.11.016 - link to the publication
  7. Highly efficient conjugate addition of diethylzinc to enones catalyzed by chiral ligands derived from (S)-mandelic acid
    Authors:
    M. Rachwalski, S. Jarzyński, S. Leśniak
    Academic press:
    Tetrahedron: Asymmetry (rok: 2013, tom: 24, strony: 1117-1119), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tetasy.2013.07.009 - link to the publication
  8. Lactic acid derived aziridinyl alcohols as highly effective catalysts for asymmetric additions of an organozinc species to aldehydes
    Authors:
    S. Leśniak, M. Rachwalski, S. Jarzyński, E. Obijalska
    Academic press:
    Tetrahedron: Asymmetry (rok: 2013, tom: 24, strony: 1336-1340), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tetasy.2013.09.008 - link to the publication
  9. Zinc(II) mediated asymmetric aldol condensation catalyzed by chiral aziridine ligands
    Authors:
    A. M. Pieczonka, S. Jarzyński, Z. Wujkowska, S. Leśniak, M. Rachwalski
    Academic press:
    Tetrahedron Letters (rok: 2015, tom: 56, strony: 6506 - 6507), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.027 - link to the publication
  10. Highly efficient conjugate additions of diethylzinc to enones promoted by chiral aziridine alcohols and aziridine ethers
    Authors:
    S. Jarzyński, M. Rachwalski, A. M. Pieczonka, Z. Wujkowska, S. Leśniak
    Academic press:
    Tetrahedron: Asymmetry (rok: 2015, tom: 26, strony: 924 - 927), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tetasy.2015.07.010 - link to the publication

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