Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Human obesity: the potential role of genes encoding sirtuins and epigenetic control of their activity.

2012/05/B/NZ5/01536

Keywords:

sirtuins adipose tissue obesity DNA methylation miRNA

Descriptors:

  • NZ5_1: Etiology of human diseases
  • NZ5_3: Pathogenesis of human diseases
  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Alina Kuryłowicz 

Number of co-investigators in the project: 6

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 357 200 PLN

Project start date (Y-m-d): 2013-02-20

Project end date (Y-m-d): 2016-08-19

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Mikrowirówka z rotorem do wirowania max. 18 probówek typu Eppendorf od 0,2 do 2,0 ml (8 500 PLN)
  2. Zestaw 6 pipet badawczych (Eppendorf Reference i Eppendorf Research) i pipeta elektroniczna 0,5-10µl (Eppendorf Xplorer) (12 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (1)
  1. SIRT1 and SIRT7 expression in adipose tissues of obese and normal-weight individuals is regulated by microRNAs but not by methylation status.
    Authors:
    Kurylowicz A, Owczarz M, Polosak J, Jonas MI, Lisik W, Jonas M, Chmura A, Puzianowska-Kuznicka M.
    Academic press:
    International Journal of Obesity (London). (rok: 2016, tom: 40 (11), strony: 1635-1642), Wydawca: Nature
    Status:
    Published
    DOI:
    0.1038/ijo.2016.131. - link to the publication
  2. Adiponectin/resistin interplay in serum and in adipose tissue of obese and normal-weight individuals
    Authors:
    •Jonas MI, Kurylowicz A, Bartoszewicz Z, Lisik W, Jonas M, Domienik-Karlowicz J, Puzianowska-Kuznicka M
    Academic press:
    Diabetology and Metabolic Syndrome (rok: 2017, tom: 0,440972222222222, strony: 0,440972222222222), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s13098-017-0293-2 - link to the publication
  3. NGS Reveals Molecular Pathways Affected by Obesity and Weight Loss-Related Changes in miRNA Levels in Adipose Tissue
    Authors:
    •Kuryłowicz A, Wicik Z, Owczarz M, Jonas MI, Kotlarek M, Świerniak M, Lisik W, Jonas M, Noszczyk B, Puzianowska-Kuźnicka M.
    Academic press:
    International Journal of Molecular Sciences (rok: 2017, tom: 19 (1), strony: pii: E66), Wydawca: MDPI Open Access Journals
    Status:
    Published
    DOI:
    10.3390/ijms19010066 - link to the publication
  4. In Search of New Therapeutic Targets in Obesity Treatment: Sirtuins.
    Authors:
    Kuryłowicz A
    Academic press:
    International Journal of Molecular Sciences (rok: 2016, tom: 17 (4), strony: pii: E572), Wydawca: MDPI Open Access Journals
    Status:
    Published
    DOI:
    10.3390/ijms17040572 - link to the publication
  1. Interferencja miRNA, a nie metylacja promotorów, ma wpływ na ekspresję genów SIRT1 i SIRT7 w tkankach tłuszczowych osób otyłych i o prawidłowej masie ciała.
    Authors:
    Kurylowicz A, Pietrzykowska M, Owczarz M, Polosak J, Jonas MI, Lisik W, Jonas M, Chmura A, Puzianowska-Kuznicka M
    Conference:
    XXI Zjazd Polskiego Towarzystwa Endokrynologicznego (rok: 2016, ), Wydawca: Via medica
    Data:
    konferencja 15-17.09.2016r
    Status:
    Published

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