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Information of the project and the call

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Study of the effect of 17-beta estradiol on expression of gene encoding hypoxia inducible factor - 1 alpha (HIF-1 alpha) by epigenetic mechanisms in carcinogenesis of colorectal cancer.

2012/05/N/NZ5/00844

Keywords:

colorectal cancer estradiol hypoxia epigenetics

Descriptors:

  • NZ1_1: Molecular biology
  • NZ3_1: Cell biology
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski I

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Agnieszka Rawłuszko-Wieczorek 

Number of co-investigators in the project: 3

Call: PRELUDIUM 3 - announced on 2012-03-15

Amount awarded: 150 000 PLN

Project start date (Y-m-d): 2013-01-29

Project end date (Y-m-d): 2016-01-28

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (2)
  1. Clinical significance of DNA methylation mRNA levels of TET family members in colorectal cancer.
    Authors:
    Rawłuszko-Wieczorek AA, Siera A, Horbacka K, Horst N, Krokowicz P, Jagodziński PP.
    Academic press:
    Journal of Cancer Research and Clinical Oncology (rok: 2015, tom: 141, strony: 1379-1392), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00432-014-1901-2 - link to the publication
  2. Prognostic potential of DNA methylation and transcript levels of HIF1A and EPAS1 in colorectal cancer
    Authors:
    Rawłuszko-Wieczorek AA, Horbacka K, Krokowicz P, Misztal M, Jagodziński PP
    Academic press:
    Molecular Cancer Research (rok: 2014, tom: 12, strony: 1112-1127), Wydawca: American Association for Cancer Research, Inc
    Status:
    Published
    DOI:
    10.1158/1541-7786.MCR-14-0054 - link to the publication
  3. Significance of intratissue estrogen concentration coupled with estrogen receptors levels in colorectal cancer prognosis
    Authors:
    Agnieszka Anna Rawłuszko-Wieczorek, Łukasz Marczak, Nikodem Horst, Karolina Horbacka, Piotr Krokowicz, Paweł Piotr Jagodziński
    Academic press:
    Oncotarget (rok: 2017, tom: 8, strony: 115546-115560), Wydawca: oncotarget
    Status:
    Published
    DOI:
    10.18632/oncotarget.23309 - link to the publication
  4. TET proteins in cancer: Current 'state of the art'
    Authors:
    Rawłuszko-Wieczorek AA, Siera A, Jagodziński PP
    Academic press:
    Critical Reviews in Oncology/Hematology (rok: 2015, tom: 96, strony: 425-436), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.critrevonc.2015.07.008 - link to the publication
  1. Epigenetic regulation of hypoxia-inducible factor -3α (HIF-3α) expression in colorectal cancer
    Authors:
    Rawłuszko-Wieczorek AA, Bujnicka KE, Horbacka K, Horst N, Krokowicz P, Jagodzińnski PP
    Conference:
    23rd Congress of the International Union of Biochemistry and Molecular Biology (IUBMB) and 44th Annual Meeting of the Brazilian Society for Biochemistry and Molecular Biology – SBBq (rok: 2015, ), Wydawca: Brazilian Society for Biochemistry and Molecular Biology
    Data:
    konferencja 24.08-28.08.2015
    Status:
    Published
  2. Significance of DNA methylation in regulation of hypoxia-inducible factor -3a expression in colorectal cancer
    Authors:
    Rawłuszko-Wieczorek AA, Bujnicka KE, Horbacka K, Krokowicz P, Jagodzińnski PP
    Conference:
    FEBS EMBO 2014 Conference (rok: 2014, ), Wydawca: Wiley
    Data:
    konferencja 30.08.2014-3.09.2014
    Status:
    Published
    DOI:
    link to the publication

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