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Molecular basis of antibacterial activity of thiosemicarbazide-based compounds

2012/05/D/NZ7/02278

Keywords:

1,4-disubstituted thiosemicarbazide antibacterial activity bacterial topoisomerases lipophilicity structural studies physico-chemical studies

Descriptors:

  • NZ7_14:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agata Paneth 

Number of co-investigators in the project: 2

Call: SONATA 3 - announced on 2012-03-15

Amount awarded: 283 750 PLN

Project start date (Y-m-d): 2013-02-04

Project end date (Y-m-d): 2017-08-03

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (15)
  1. Synthesis and antibacterial activity of 1,4-dibenzoylthiosemicarbazide derivatives
    Authors:
    Agata Paneth, Paweł Stączek, Tomasz Plech, Aleksandra Strzelczyk, Dominika Janowska, Joanna Stefańska, Katarzyna Dzitko, Monika Wujec, Szymon Kosiek, Piotr Paneth
    Academic press:
    Biomedicine & Pharmacotherapy (rok: 2017, tom: 88, strony: 1235-1242), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2017.02.001 - link to the publication
  2. Structure-activity relationship studies of microbiologically active thiosemicarbazides derived from hydroxybenzoic acid hydrazides
    Authors:
    Tomasz Plech, Agata Paneth, Barbara Kaproń, Urszula Kosikowska, Anna Malm, Aleksandra Strzelczyk, Paweł Stączek
    Academic press:
    Chemical Biology & Drug Design (rok: 2014, tom: 85, strony: 315-325), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/cbdd.12392 - link to the publication
  3. 1,4-Disubstituted Thiosemicarbazide Derivatives are Potent Inhibitors of Toxoplasma gondii Proliferation
    Authors:
    Katarzyna Dzitko, Agata Paneth, Tomasz Plech, Jakub Pawełczyk, Paweł Stączek, Joanna Stefańska, Piotr Paneth
    Academic press:
    Molecules (rok: 2014, tom: 19, strony: 9926-9943), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules19079926 - link to the publication
  4. Structure-activity relationship studies of microbiologically active thiosemicarbazides derived from hydroxybenzoic acid hydrazides
    Authors:
    Tomasz Plech, Agata Paneth, Barbara Kaproń, Urszula Kosikowska, Anna Malm, Aleksandra Strzelczyk, Paweł Stączek
    Academic press:
    Chemical Biology & Drug Design (rok: 2014, tom: 85, strony: 315-325), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/cbdd.12392 - link to the publication
  5. Lipophilicity Studies on Thiosemicarbazide Derivatives
    Authors:
    Agata Paneth, Anna Hawrył, Tomasz Plech, Mirosław Hawrył, Ryszard Świeboda, Dominika Janowska, Monika Wujec, Piotr Paneth
    Academic press:
    Molecules (rok: 2017, tom: 22, strony: 952), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules22060952 - link to the publication
  6. Lipophilicity Studies on Thiosemicarbazide Derivatives
    Authors:
    Agata Paneth, Anna Hawrył, Tomasz Plech, Mirosław Hawrył, Ryszard Świeboda, Dominika Janowska, Monika Wujec, Piotr Paneth
    Academic press:
    Molecules (rok: 2017, tom: 22, strony: 952), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules22060952 - link to the publication
  7. Molecular Properties Prediction, Docking Studies, and Antimicrobial Screening of 1,3,4-Thiadiazole and S-Triazole Derivatives
    Authors:
    Agata Siwek, Tomasz Plech, Joanna Stefańska, Paweł Stączek and Aleksandra Strzelczyk
    Academic press:
    Current Computer-Aided Drug Design (rok: 2014, tom: 10, strony: 45730), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/15734099113096660033 - link to the publication
  8. Antimicrobial and physicochemical characterizations of thiosemicarbazide and s-triazole derivatives
    Authors:
    Edyta Kuśmierz, Agata Siwek, Urszula Kosikowska, Anna Malm, Tomasz Plech, Andrzej Wróbel, Monika Wujec 
    Academic press:
    Phosphorus, Sulfur, and Silicon and the Related Elements (rok: 2014, tom: 189, strony: 45664), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/10426507.2014.902831 - link to the publication
  9. 1,4-Disubstituted Thiosemicarbazide Derivatives are Potent Inhibitors of Toxoplasma gondii Proliferation
    Authors:
    Katarzyna Dzitko, Agata Paneth, Tomasz Plech, Jakub Pawełczyk, Paweł Stączek, Joanna Stefańska, Piotr Paneth
    Academic press:
    Molecules (rok: 2014, tom: 19, strony: 9926-9943), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules19079926 - link to the publication
  10. Conformational Preference of Potassium Salts of N-Acylhydrazinecarbodithioates with Antifungal Activity. Combined Experimental and Theoretical Approach ;
    Authors:
    Agata Siwek, Tomasz Plech, Nazar Trotsko, Urszula Kosikowska, Anna Malm, Katarzyna Dzitko, Piotr Paneth
    Academic press:
    Current Computer-Aided Drug Design (rok: 2014, tom: 10, strony: 205-216), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1573409910666140521152701 - link to the publication
  11. Synthesis, Characterization and Antimicrobial Activity of 4-benzoyl-1-(pyrazin-2-ylcarbonyl)-thiosemicarbazide
    Authors:
    Dominika Hagel, Agata Siwek, Tomasz Plech
    Academic press:
    Journal of Single Molecule Research (rok: 2014, tom: 2, strony: 45821), Wydawca: Sciknow
    Status:
    Published
    DOI:
    10.12966/jsmr.03.02.2014 - link to the publication
  12. Antimicrobial and physicochemical characterizations of thiosemicarbazide and s-triazole derivatives
    Authors:
    Edyta Kuśmierz, Agata Siwek, Urszula Kosikowska, Anna Malm, Tomasz Plech, Andrzej Wróbel, Monika Wujec 
    Academic press:
    Phosphorus, Sulfur, and Silicon and the Related Elements (rok: 2014, tom: 189, strony: 45664), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/10426507.2014.902831 - link to the publication
  13. Design, synthesis and biological evaluation of 4- benzoyl-1-dichlorobenzoylthiosemicarbazides as potent Gram-positive antibacterial agents
    Authors:
    Agata Paneth, Tomasz Plech, Barbara Kaproń, Dominika Hagel, Urszula Kosikowska, Edyta Kuśmierz, Katarzyna Dzitko, Piotr Paneth
    Academic press:
    Journal of Enzyme Inhibition & Medicinal Chemistry (rok: 2016, tom: 31, strony: 434–440), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.3109/14756366.2015.1036050 - link to the publication
  14. Conformational Preference of Potassium Salts of N-Acylhydrazinecarbodithioates with Antifungal Activity. Combined Experimental and Theoretical Approach ;
    Authors:
    Agata Siwek, Tomasz Plech, Nazar Trotsko, Urszula Kosikowska, Anna Malm, Katarzyna Dzitko, Piotr Paneth
    Academic press:
    Current Computer-Aided Drug Design (rok: 2014, tom: 10, strony: 205-216), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1573409910666140521152701 - link to the publication
  15. Biological evaluation and molecular modelling study of thiosemicarbazide derivatives as bacterial type IIA topoisomerases inhibitors
    Authors:
    Agata Paneth, Paweł Stączek, Tomasz Plech, Aleksandra Strzelczyk, Katarzyna Dzitko, Monika Wujec, Edyta Kuśmierz, Urszula Kosikowska, Agnieszka Grzegorczyk, Piotr Paneth
    Academic press:
    Journal of Enzyme Inhibition and Medicinal Chemistry (rok: 2016, tom: 31, strony: 14–22), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.3109/14756366.2014.1003214 - link to the publication

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