Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of sirtuins and AMPK protein kinase in insulin resistance of podocytes

2012/05/B/NZ5/01448

Keywords:

insulin resistance glucose podocytes AMPK SIRT1

Descriptors:

  • NZ3_2: Cell physiology
  • NZ1_1: Molecular biology
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Dorota Rogacka 

Number of co-investigators in the project: 5

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 580 350 PLN

Project start date (Y-m-d): 2013-02-11

Project end date (Y-m-d): 2016-02-10

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Licznik scyntylacyjny (230 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (1)
  1. Involvement of the AMPK-PTEN pathway in insulin resistance induced by high glucose in cultured rat podocytes.
    Authors:
    Dorota Rogacka, Agnieszka Piwkowska, Irena Audzeyenka, Stefan Angielski, Maciej Jankowski
    Academic press:
    The International Journal of Biochemistry & Cell Biology (rok: 2014, tom: 51, strony: 120-130), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biocel.2014.04.008. - link to the publication
  2. SIRT1-AMPK crosstalk is involved in high glucose-dependent impairment of insulin responsiveness in primary rat podocytes
    Authors:
    Dorota Rogacka, Agnieszka Piwkowska, Irena Audzeyenka, Stefan Angielski, Maciej Jankowski
    Academic press:
    Experimental Cell Research (rok: 2016, tom: 349, strony: 328-338), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.yexcr.2016.11.005 - link to the publication
  1. The Role of AMPK-SIRT1 Pathway in High Glucose-Induced Insulin Resistance in Rat Cultured Podocytes
    Authors:
    Dorota Rogacka, Agnieszka Piwkowska, Irena Audzeyenka, Stefan Angielski, Maciej Jankowski
    Conference:
    Experimental Biology (rok: 2015, ), Wydawca: The Federation of American Societies for Experimental Biology
    Data:
    konferencja 28 marca - 1 kwietnia
    Status:
    Published