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Regulation of the molecular mechanisms of heme absorption: studies on piglets with iron deficiency anemia supplemented with heme iron.

2012/05/E/NZ5/02126

Keywords

Descriptors

  • NZ5_8: Leczenie chorób zwierząt
  • NZ5_7: Leczenie chorób człowieka

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Instytut Genetyki i Hodowli Zwierząt PAN

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Rafał Radosław Starzyński

Number of co-investigators in the project: 4

Call

SONATA BIS 1 – announced on 2012-03-15

Amount awarded
1 324 447 PLN
Project start date
2013-01-31
Project end date
2017-05-31
Project duration
52 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Dewar (81 litrów). Cost: 15 000 PLN
  2. Dygestorium metalowe DSM-12.00 S S. Cost: 19 335 PLN
  3. Odyssey CLx - Infared Imaging System. Cost: 190 000 PLN

Information in the final report

Publication in academic press/journals (6)

  1. Urinary hepcidin levels in iron-deficient and iron-supplemented piglets are correlated with hepatic hepcidin mRNA expression, serum hepcidin concentrations and hematological and biochemical indicators of iron status.

    Authors:
    Staroń R., Van Swelm R.P.L., Lipiński P., Gajowiak A., Lenartowicz M., Gajewska M., Pieszka M., Laarakkers C. M. M., Swinkels D.W., and Starzyński R.R
    Academic press:
    PlosOne (year: 2015, volume: 0(8):e0136695, pages: 46034), Publisher: PUBLIC LIBRARY SCIENCE
    Status:
    Published
    DOI:
    10.1371/journal.pone.0136695 – link to the publication

  2. Diagnostics of iron-deficiency anaemia in piglets in the early postnatal period – a review.

    Authors:
    GODYŃ D., PIESZKA M., LIPIŃSKI P., STARZYŃSKI R.R.
    Academic press:
    Animal Science Papers and Reports. (year: 2016, volume: 34/4, pages: 307-318), Publisher: IGHZ PAN
    Status:
    Published
    DOI:
    link to the publication

  3. Metabolizm hemu jako integralny element homeostazy żelaza/Heme metabolism as an integral part of iron homeostasis

    Authors:
    Paweł Lipiński, Rafał R. Starzyński, Agnieszka Styś, Anna Gajowiak, Robert Staroń
    Academic press:
    PHMD (year: 2014, volume: 68/2014/IV, pages: 557-70.), Publisher: Instytut Immunologii i Terapii Doświadczalnej PAN
    Status:
    Published
    DOI:
    10.5604/17322693.1102284. – link to the publication

  4. Iron supplementation in suckling piglets: how to correct iron deficiency anemia without affecting plasma hepcidin levels.

    Authors:
    Starzyński RR1, Laarakkers CM, Tjalsma H, Swinkels DW, Pieszka M, Styś A, Mickiewicz M, Lipiński P.
    Academic press:
    PLOS One (year: 2013, volume: 8(5): e64022., pages: 8(5): e64022.), Publisher: PUBLIC LIBRARY SCIENCE
    Status:
    Published
    DOI:
    10.1371/journal.pone.0064022 – link to the publication

  5. Dietary hemoglobin rescues young piglets from severe iron deficiency anemia: deciphering the pathways of heme iron absorption.

    Authors:
    Staroń R., Lipiński, P. Lenartowicz M., Bednarz A., Gajowiak A., Ewa Smuda E., Wojciech Krzeptowski W., Marek Pieszka M., Tamara Korolonek T., Iqbal Hamza I., Dorine W. Swinkels DW., Rachel P.L. Van Swelm RPL., and Rafał R. Starzyński.
    Academic press:
    PlosONE (year: 2017, volume: jul 13(7), pages: 46044), Publisher: PUBLIC LIBRARY SCIENCE
    Status:
    Published
    DOI:
    10.1371/journal.pone.0181117 – link to the publication

  6. Enterocyt-wąskie gardło metabolizmu żelaza

    Authors:
    Robert Staroń, Agnieszka Styś, Rafał Starzyński, Anna Gajowiak, Paweł Lipiński
    Academic press:
    Postępy Biologii Komórki (year: 2015, volume: 42, pages: 329-350), Publisher: PTB, PTA,
    Status:
    Published

Articles in post-conference publications (2)

  1. Regulation of ferroportin expression by hepatic iron and hepcidin in pregnant females and their fetuses in response to normal and iron-deficient diet.

    Authors:
    Robert Staroń, Rafał R. Starzyński, Ewa Smuda, Eunice Sindhuvi Edison, Paweł Lipiński
    Conference:
    European Iron Club, 2016 Meeting in Innsbruck (year: 2016, pages: 54-55), Publisher: European Iron Club EIC
    Date:
    conference Austria on April 7-10, 2016
    Status:
    Published

  2. Mechanisms of heme iron absorption in young pigs orally supplemented with hemoglobin

    Authors:
    Staroń R., Lipiński P., Gajowiak A., Smuda E., Dziaman T., Krzeptowski W., Lenartowicz M., Gajewska M., Pieszka M., Bederska-Łojewska D., Swinkels D.W., Van Swelm R., and. Starzynski R.R.
    Conference:
    Ferrum Rex 2nd Meeting of The Polish Iron Club (year: 2015, pages: 12), Publisher: Polskie Towarzystwo Anatomiczne i Polskie Towarzystwo Biologii Komórki
    Date:
    conference May 12-13, 2015, Jastrzębiec POLSKA
    Status:
    Published

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