Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Mechanisms of interactions between dendrimers and proteins.

2012/04/M/NZ1/00059

Keywords:

dendrimer protein interaction mechanism

Descriptors:

  • NZ1_3: Biophysics
  • ST5_10: Functional materials/nanomaterials, nanoparticles

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Maria Bryszewska 

Number of co-investigators in the project: 6

Call: HARMONIA 2 - announced on 2011-12-15

Amount awarded: 328 380 PLN

Project start date (Y-m-d): 2012-09-17

Project end date (Y-m-d): 2015-09-16

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (12)
  • Articles in post-conference publications (12)
  1. Recent patents in dendrimers for nanomedicine: evolution 2014
    Authors:
    D. Shcharbin, N. Shcharbina, M. Bryszewska
    Academic press:
    Recent Patents on Nanomedicine (rok: 2014, tom: 4, strony: 25-31), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1877912304666140609233256#sthash.a99HaLjs.dpuf - link to the publication
  2. Contribution of hydrophobicity, DNA and proteins to the cytotoxicity of cationic PAMAM dendrimers
    Authors:
    I. Halets, D. Shcharbin, B. Klajnert, M. Bryszewska
    Academic press:
    International Journal of Pharmaceutics (rok: 2013, tom: 454, strony: 45294), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ijpharm.2013.06.061 - link to the publication
  3. How to study dendrimers and dendriplexes III. Biodistribution, pharmacokinetics and toxicity in vivo
    Authors:
    D. Shcharbin. Anna Janaszewska, B. Klajnert-Maculewicz, B. Ziemba, V. Dzmitruk, I. Halets, S. Loznikova, N. Shcharbina, K. Milowska, M. Ionov, A. Shakhbazaud, M. Bryszewska
    Academic press:
    Journal of Controlled Release (rok: 2014, tom: 181, strony: 40-52), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.jconrel.2014.02.021 - link to the publication
  4. Acidosis, magnesium and acetylsalicylic acid: Effects on thrombin.
    Authors:
    N. Borisevich, S. Loznikova, A. Sukhodola, I. Halets, M. Bryszewska, D. Shcharbin
    Academic press:
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (rok: 2013, tom: 104, strony: 158-164), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.saa.2012.11.051 - link to the publication
  5. Nanoparticle corona for proteins: Mechanisms of interaction between dendrimers and proteins.
    Authors:
    Shcharbin D., Ionov M., Abashkin V., Loznikova S., Dzmitruk V., Shcharbina N, Matusevich N., Milowska K., Gałęcki K., Wysocki S., Bryszewska M.
    Academic press:
    Coll. Surfaces B: Biointerfaces (rok: 2015, tom: 134, strony: 377-383), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.colsurfb.2015.07.017 - link to the publication
  6. Stabilizing effect of small concentrations of PAMAM dendrimers at the insulin aggregation
    Authors:
    O. Nowacka, D. Shcharbin, B. Klajnert-Maculewicz, M. Bryszewska
    Academic press:
    Colloids and Surfaces B: Biointerfaces (rok: 2014, tom: 116, strony: 757-760), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.colsurfb.2014.01.056 - link to the publication
  7. Synthesis, characterization and biological properties of new hybrid carbosilane-viologen-phosphorus dendrimers
    Authors:
    Moreno S., Szwed A., El Brahmi N., Milowska K., Kurowska J., Fuentes-Paniagua E., Pedziwiatr-Werbicka E., Gabryelak T., Katir N., de la Mata F.J., Muñoz-Fernández M.A., Gomez-Ramirez R., Caminade A.M., Majoral J.-P., Bryszewska M.
    Academic press:
    RSC Advances (rok: 2015, tom: 5, strony: 25942-25958), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c5ra00960j - link to the publication
  8. Interaction of PAMAM dendrimers with bovine insulin depends on nanoparticle end-groups
    Authors:
    Nowacka O., Miłowska K., Bryszewska M.
    Academic press:
    J. Lumin. (rok: 2015, tom: 162, strony: 87-91), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jlumin.2015.02.014 - link to the publication
  9. Interference of cationic polymeric nanoparticles with clinical chemistry tets-Clinical relevance
    Authors:
    D. Shcharbin , N. Shcharbina, K. Milowska, F.J. de la Mata, M.A. Muñoz-Fernandez, S. Mignani, R. Gomez-Ramirez, J.P. Majoral, M. Bryszewska
    Academic press:
    International Journal of Pharmaceutics (rok: 2014, tom: 473, strony: 599-606), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ijpharm.2014.07.054 - link to the publication
  10. Carbosilane dendrimers inhibit α-synuclein fibrillation and prevent cells from rotenone-induced damage.
    Authors:
    Milowska K., Szwed A., Mutrynowska M., Gomez-Ramirez R., de la Mata F.J., Gabryelak T., Bryszewska M.
    Academic press:
    Int. J. Pharm. (rok: 2015, tom: 484, strony: 268-275), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijpharm.2015.02.066 - link to the publication
  11. Nanomaterials in stroke treatment: Perspectives
    Authors:
    N. Shcharbina, D. Shcharbin, M. Bryszewska
    Academic press:
    Stroke (rok: 2013, tom: 44, strony: 2351-2355), Wydawca: American Heart Association
    Status:
    Published
    DOI:
    10.1161/STROKEAHA.113.001298 - link to the publication
  12. Poly(amidoamine) dendrimer complexes as a platform for gene delivery
    Authors:
    D. Shcharbin, A. Shakhbazau, M. Bryszewska
    Academic press:
    Expert Opinion on Drug Delivery (rok: 2013, tom: 10, strony: 1687-1698), Wydawca: Informa Healthcare, U.K.
    Status:
    Published
    DOI:
    10.1517/17425247.2013.853661 - link to the publication
  1. Application of PPI sugar modified dendrimers in neurodegenerative disorders
    Authors:
    P. Piatek, M. Marcinkowska, A. Janaszewska, B. Voit, D. Appelhans, M. Bryszewska, B. Klajnert-Maculewicz
    Conference:
    Assets of Chemistry in Drug Discovery (rok: 2014, ), Wydawca: CRDP Montpellier
    Data:
    konferencja 24-25 March 2014
    Status:
    Published
  2. Luminescent analysis of the impact of phosphorus dendrimers of 3rd and 4th generations at the conformation and structural-dinamical state of human thrombin
    Authors:
    V.M. Abashkin, S. Zh. Loznikova, K. Milowska, J.-P. Majoral
    Conference:
    Molecular, Membrane and Cellular Basics for Functioning of Biosystems (rok: 2014, ), Wydawca: Białoruska Akademia Nauk
    Data:
    konferencja 17-20 czerwca
    Status:
    Published
  3. Luminescent analysis of the interaction between PAMAM dendrimers of 3rd and 4th generation and plasma proteins or cytosolic enzymes
    Authors:
    I.V. Halets, A.L. Krauchonak, D. Shcharbin, M. Bryszewska
    Conference:
    IV Kongres Fizyków Białorusi (rok: 2013, ), Wydawca: Kowczeg, Mińsk
    Data:
    konferencja 24-26 kwietnia
    Status:
    Published
  4. Ocena właściwości biologicznych dendrymerów hybrydowych na podstawie ich interakcji z białkami
    Authors:
    Szwed A., Milowska K., Gabryelak T.
    Conference:
    I Ogólnopolska Konferencja Doktorantów Nauk o Życiu (rok: 2015, ), Wydawca: Uniwersytet Łódzki
    Data:
    konferencja 20-22 kwietnia
    Status:
    Published
  5. Carbosilane dendrimers affect the fibrillation of alpha-synuclein
    Authors:
    Milowska K., Gomez-Ramirez R., de la Mata .F.J., Gabryelak T., Bryszewska M.
    Conference:
    Polymer processing with resulting morphology and properties: feet in the present and eyes at the future (rok: 2015, ), Wydawca: Uniwersytet Salerno
    Data:
    konferencja 15-17 października
    Status:
    Published
  6. Carbosilane-viologen-phosphorus interaction with proteins base on alkaline phosphatase
    Authors:
    Szwed A., Milowska K., Bryszewska M., Gomez-Ramirez R., de la Mata .J., Gabryelak T.
    Conference:
    Chemistry and biology: A permanent dialogue. 22nd Young Research Fellows Meeting (rok: 2015, ), Wydawca: Journees Jeunes Chercheurs
    Data:
    konferencja 4-6 lutego
    Status:
    Published
  7. Interaction between polyamidoamine dendrimers and regulatory plasma proteins: alkaline phosphatase and L-lactic dehydrogenase
    Authors:
    K. Milowska, M. Ionov, E. Borowska, I. Halets, T. Gabryelak, S. Shcharbin, M. Bryszewska
    Conference:
    38th FEBS CONGRESS (Saint Petersburg) (rok: 2013, ), Wydawca: Willey Blackwell
    Data:
    konferencja 6-11 lipca
    Status:
    Published
  8. Wpływ dendrymerów karbokrzemowo-wiologenowo-fosforowych na strukturę drugorzędową wybranych białek regulatorowych"
    Authors:
    Szwed A., Milowska K., Bryszewska M., Gabryelak T.
    Conference:
    IV Konferencja Biologii Molekularnej, (rok: 2015, ), Wydawca: Uniwersytet Łódzki
    Data:
    konferencja 26-28 marca
    Status:
    Published
  9. Interaction between Si-C carbosilane dendrimers and albumin
    Authors:
    V. Dzmitruk, J. de la Mata, R. Gomez-Ramirez, E. Pedziwiatr-Werbicka, M. Bryszewska, D.Shcharbin,
    Conference:
    Molecular, Membrane and Cellular Basics for Functioning of Biosystems (rok: 2014, ), Wydawca: Białoruska Akademia Nauk
    Data:
    konferencja 17-20.06
    Status:
    Published
  10. Biologiczne właściwości dendrymerów wiologenowo-karbokrzemowo-fosforowych (SMT)
    Authors:
    A. Szwed, J. Kurowska, K. Miłowska, M. Bryszewska, T. Gabryelak
    Conference:
    III Studencka Konferencja Biologii Molekularnej (rok: 2014, ), Wydawca: Uniwersytet Łódzki
    Data:
    konferencja 20-22 marca
    Status:
    Published
  11. Influence of PAMAM dendrimers on the human insulin
    Authors:
    Nowacka O., Milowska K., Ionov M., Bryszewska M.
    Conference:
    Polymer processing with resulting morphology and properties: feet in the present and eyes at the future (rok: 2015, ), Wydawca: Uniwersytet Salerno
    Data:
    konferencja 15-15 pażdziernika
    Status:
    Published
  12. The role of phosphorus dendrimers in alpha-synuclein fibrillation
    Authors:
    Milowska K., Apartsin E., Majoral J.P., Gabryelak T., Bryszewska M.
    Conference:
    2nd Worlds Congress on NeuroTherapeutics: Dilmmas, Debates, Discussions (rok: 2015, ), Wydawca: CongressMed
    Data:
    konferencja 3-6 września
    Status:
    Published