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Information on the principal investigator and host institution

Information of the project and the call

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Studies on apoptosis and oxidative damage to biological molecules in tissue-specific and non-specific growth hormone receptor knockout (GHRKO) mice

2012/04/M/NZ4/00198

Keywords:

apoptosis oxidative stress growth hormone receptor tissue-specific gene knockout GHRKO mice IGF-I

Descriptors:

  • NZ4_12: Other related subjects

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski z Oddziałem Stomatologicznym

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Adam Gesing 

Number of co-investigators in the project: 6

Call: HARMONIA 2 - announced on 2011-12-15

Amount awarded: 350 000 PLN

Project start date (Y-m-d): 2012-09-24

Project end date (Y-m-d): 2015-09-23

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (8)
  1. A Long-lived Mouse Lacking Both Growth Hormone and Growth Hormone Receptor: A New Animal Model for Aging Studies
    Authors:
    Gesing A, Wiesenborn D, Do A, Menon V, Schneider A, Victoria B, Stout MB, Kopchick JJ, Bartke A, Masternak MM
    Academic press:
    The Journals of Gerontology Series A: Biological Sciences and Medical Sciences; J Gerontol A Biol Sci Med Sci (rok: 2016, ), Wydawca: Oxford University Press Inc.
    Status:
    Published
    DOI:
    10.1093/gerona/glw193 - link to the publication
  2. Gene expression of key regulators of mitochondrial biogenesis is sex dependent in mice with growth hormone receptor deletion in liver
    Authors:
    Zawada I, Masternak MM, List EO, Stout MB, Berryman DE, Lewinski A, Kopchick JJ, Bartke A, Karbownik-Lewinska M, Gesing A
    Academic press:
    Aging (Albany NY) (rok: 2015, tom: 7, strony: 195-204), Wydawca: Impact Journals, LLC
    Status:
    Published
    DOI:
    brak - link to the publication
  3. Growth hormone abolishes beneficial effects of calorie restriction in long-lived Ames dwarf mice
    Authors:
    Gesing A, Al-Regaiey KA, Bartke A, Masternak MM
    Academic press:
    Experimental Gerontology; Exp Gerontol (rok: 2014, tom: 58, strony: 219-229), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.exger.2014.08.010 - link to the publication
  4. Expression of Apoptosis-Related Genes in Liver-Specific Growth Hormone Receptor Gene–Disrupted Mice Is Sex Dependent
    Authors:
    Gesing A, Wang F, List EO, Berryman DE, Masternak MM, Lewinski A, Karbownik-Lewinska M, Kopchick JJ, Bartke A
    Academic press:
    The Journals of Gerontology Series A: Biological Sciences and Medical Sciences; J Gerontol A Biol Sci Med Sci (rok: 2015, tom: 70, strony: 44-52), Wydawca: Oxford University Press Inc.
    Status:
    Published
    DOI:
    10.1093/gerona/glu008 - link to the publication
  5. The role of transplanted visceral fat from the long-lived growth hormone receptor knockout mice on insulin signaling
    Authors:
    Bennis MT, Schneider A, Victoria B, Do A, Wiesenborn DS, Spinel L, Gesing A, Kopchick JJ, Siddiqi SA, Masternak MM
    Academic press:
    GeroScience (rok: 2017, tom: 39, strony: 51-59), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11357-017-9957-y - link to the publication
  6. Pioglitazone does not improve insulin signaling in mice with GH over-expression
    Authors:
    Gesing A, Bartke A, Masternak MM
    Academic press:
    Journal of Endocrinology; J Endocrinol (rok: 2013, tom: 219, strony: 109-117), Wydawca: Bioscientifica LTD
    Status:
    Published
    DOI:
    10.1530/JOE-13-0124 - link to the publication
  7. The contribution of visceral fat to improved insulin signaling in Ames dwarf mice
    Authors:
    Menon V, Zhi X, Hossain T, Bartke A, Spong A, Gesing A, Masternak MM
    Academic press:
    Aging Cell (rok: 2014, tom: 13, strony: 497-506), Wydawca: Wiley-Blackwell
    Status:
    Published
    DOI:
    10.1111/acel.12201 - link to the publication
  8. Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice
    Authors:
    Stout MB, Swindell WR, Zhi X, Rohde K, List EO, Berryman DE, Kopchick JJ, Gesing A, Fang Y, Masternak MM
    Academic press:
    Oncotarget (rok: 2015, tom: 6, strony: 26702-26715), Wydawca: Impact Journals, LLC
    Status:
    Published
    DOI:
    10.18632/oncotarget.5760 - link to the publication

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