Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Regulation of ALKBH proteins expression in cancer and its role in cancer therapy.

2011/03/B/NZ4/02425

Keywords:

ALKBH dioxygenases cancer chemotherapy targeted therapy alkylating leasions

Descriptors:

  • NZ3_1: Cell biology
  • NZ5_1: Etiology of human diseases
  • NZ1_1: Molecular biology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Biochemii i Biofizyki PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Elżbieta Grzesiuk 

Number of co-investigators in the project: 5

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 537 390 PLN

Project start date (Y-m-d): 2012-08-06

Project end date (Y-m-d): 2016-02-05

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Apart do elektroforezy białek (2 szt.) (8 600 PLN)
  2. Zestaw do półsuchego transferu oraz zasilacz wysokoamperowy (2 szt.) (21 400 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (2)
  1. Ada response – a strategy for repair of alkylated DNA in bacteria
    Authors:
    Mielecki D., Grzesiuk E.
    Academic press:
    FEMS Microbiology Letters (rok: 2014, tom: 355, strony: 1–11), Wydawca: Federation of European Microbiological Societies
    Status:
    Published
    DOI:
    10.1111/1574-6968.12462 - link to the publication
  2. Obstructive sleep apnea and cancer: effects of intermittent hypoxia?
    Authors:
    Kukwa W, Migacz E, Druc K, Grzesiuk E, Czarnecka AM.
    Academic press:
    Future Oncology (rok: 2015, tom: 11(24), strony: 3285-98), Wydawca: Future Medicine
    Status:
    Published
    DOI:
    10.2217/fon.15.216 - link to the publication
  3. Evaluation of anti-cancer activity of new stilbene and methoxydibenzo[b,f]oxepin derivatives
    Authors:
    Garbicz D, Mielecki D, Wrzesiński M, Pilżys T, Marcinkowski M, Piwowarski J, Dębski J, Palak E, Szczeciński P, Krawczyk H, Grzesiuk E
    Academic press:
    Current Cancer Drug Targets (rok: 2017, tom: 17, strony: 45303), Wydawca: Bentham Science
    Status:
    Accepted for publication
    DOI:
    10.2174/1568009617666170623120742 - link to the publication
  4. Effects of changes in intracellular iron pool on AlkB-dependent and AlkB-independent mechanisms protecting E.coli cells against mutagenic action of alkylating agent.
    Authors:
    Sikora A, Maciejewska AM, Poznański J, Pilżys T, Marcinkowski M, Dylewska M, Piwowarski J, Jakubczak W, Pawlak K, Grzesiuk E.
    Academic press:
    MUTATION RESEARCH/FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (rok: 2015, tom: 778, strony: 52-60), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.mrfmmm.2015.05.009 - link to the publication
  1. How to avoid the most frequent mistakes in Western blot analaysis - FTO protein as general example
    Authors:
    M. Marcinkowski, T. Pilżys, J. Piwowarski, E. Grzesiuk
    Conference:
    40th FEBS Congress, The Biochemical Basis of Life (rok: 2015, ), Wydawca: The FEBS Journal
    Data:
    konferencja 4-9 lipiec
    Status:
    Published
    DOI:
    link to the publication
  2. Do changes in free Fe pool influence AlkB-dependent mechanism of DNA repair in bacterial and tumor cells?
    Authors:
    Sikora A., Maciejewska A., Poznański J., Pilżys T., Piwowarski J., Grzesiuk E.
    Conference:
    Mutagenesis (rok: 2014, ), Wydawca: Gordon Research Conference
    Data:
    konferencja 15-20.06.2014
    Status:
    Published
    DOI:
    link to the publication

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