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Information of the project and the call

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Effect of beta-hydroxy-beta-methylbutyrate and gamma-oryzanol on transcriptiomic profiles of genes and miRNA expression in cultures of equine primary muscular cells

2011/03/B/NZ5/05697

Keywords:

culture cells,satellite cells beta-hydroxy-beta-methylbutyrate HMB gamma-oryzanol GO H2O2 microRNA microarray oxidative stress proteolisis

Descriptors:

  • NZ5_9: Other related subjects
  • NZ5_8: Animal disease treatment
  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Tomasz Sadkowski 

Number of co-investigators in the project: 5

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 377 000 PLN

Project start date (Y-m-d): 2012-08-13

Project end date (Y-m-d): 2015-08-12

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (9)
  1. Effect of β-hydroxy-β-methylbutyrate on miRNA expression in differentiating equine satellite cells exposed to hydrogen peroxide
    Authors:
    Karolina A. Chodkowska, Anna Ciecierska, Kinga Majchrzak, Piotr Ostaszewski and Tomasz Sadkowski
    Academic press:
    Genes & Nutrition (rok: 2018, tom: 13, strony: 10), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s12263-018-0598-2 - link to the publication
  2. Dietary supplementation of β-hydroxy-β-methylbutyrate in animals – a review
    Authors:
    K. A. Szcześniak, P. Ostaszewski, J. C. Fuller Jr, A. Ciecierska and T. Sadkowski
    Academic press:
    Journal of Animal Physiology and Animal Nutrition (rok: 2014, tom: online, strony: 45304), Wydawca: Blackwell Verlag GmbH
    Status:
    Published
    DOI:
    10.1111/jpn.12234 - link to the publication
  3. MicroRNA function in domestic animal physiology and diseases: a promising diagnostic tool for veterinary use
    Authors:
    KAROLINA A. CHODKOWSKA, TOMASZ SADKOWSKI, PIOTR OSTASZEWSKI
    Academic press:
    Medycyna Weterynaryjna (rok: 2017, tom: 73 (3), strony: 156-165), Wydawca: Uniwersytet im Marii Curie-Skłodowskiej
    Status:
    Published
    DOI:
    brak - link to the publication
  4. Characterisation of equine satellite cell transcriptomic profile response to β-hydroxy-β-methylbutyrate (HMB)
    Authors:
    Szcześniak, K. A., Ciecierska, A., Ostaszewski, P., & Sadkowski, T.
    Academic press:
    British Journal of Nutrition : (rok: 2016, tom: 116 (8), strony: 1315-1325), Wydawca: Cambridge University Press
    Status:
    Published
    DOI:
    10.1017/S000711451600324X - link to the publication
  5. Investigation of nutriactive phytochemical - gamma-oryzanol in experimental animal models
    Authors:
    Szcześniak K. A., Ostaszewski P., Ciecierska A., Sadkowski T.
    Academic press:
    Journal of Animal Physiology and Animal Nutrition (rok: 2015, tom: brak, strony: brak), Wydawca: Blackwell Verlag GmbH
    Status:
    Published
    DOI:
    10.1111/jpn.12428 - link to the publication
  6. Transcriptomic profile adaptations following exposure of equine satellite cells to nutriactive phytochemical gamma-oryzanol
    Authors:
    Szcześniak K. A. , Ciecierska A., Ostaszewski P., Chodkowska K. A., Sadkowski T.
    Academic press:
    Genes and Nutrition (rok: 2016, tom: 11 (1), strony: 5), Wydawca: Springer
    Status:
    Published
    DOI:
    brak - link to the publication
  1. Changes in miRNA and gene expression in differentiating equine satellite cells pre-incubated with β-hydroxy-β-methylbutyrate and exposed to hydrogen peroxide
    Authors:
    K.A. Chodkowska, A. Ciecierska, P. Ostaszewski, K. Szcześniak, H.Leontowicz, T. Sadkowski
    Conference:
    Physiology and Biochemistry in Animal Nutrition (rok: 2015, ), Wydawca: The Kielanowski Institute of Animal Physiology and Nutrition, PAS
    Data:
    konferencja 23-24 września
    Status:
    Published
  2. Effect of β-hydroxy-β-methylbutyrate on miRNA expression in differentiating equine skeletal muscle satellite cells.
    Authors:
    Chodkowska KA, Ciecierska A, Ostaszewski P , Szcześniak K, Sadkowski T.
    Conference:
    XXVI Kongresu Polskiego Towarzystwa Fizjologicznego (rok: 2014, ), Wydawca: Journal of Physiology and Pharmacology
    Data:
    konferencja 18.09-20.09
    Status:
    Published
  3. Comparison of microRNA profile changes following exposure of equine satellite cells to gamma-oryzanol and β-hydroxy-β-methylbutyrate
    Authors:
    Szcześniak K.A., Ciecierska A., Ostaszewski P., Chodkowska K.A., Sadkowski T.
    Conference:
    Physiology and Biochemistry in Animal Nutrition (rok: 2015, ), Wydawca: The Kielanowski Institute of Animal Physiology and Nutrition, PAS
    Data:
    konferencja 23-24 września
    Status:
    Published
  4. β-hydroxy-β-methylbutyrate (HMB) may affect equine myogenic cell proliferation and differentiation via IGF1 signalling downstream substrates and transforming growth factor-β superfamily
    Authors:
    Katarzyna A. Szcześniak, Anna Ciecierska, Alicja Majewska, Piotr Ostaszewski, Karolina Chodkowska, Tomasz Sadkowski
    Conference:
    1st World Conference on Innovative Animal Nutrition and Feeding (WIANF) (rok: 2015, ), Wydawca: 1st World Conference on Innovative Animal Nutrition and Feeding (WIANF)
    Data:
    konferencja 15-17 październik
    Status:
    Published
  5. Effect of γ-oryzanol on transcriptomic profile of differentiating equine satellite cells.
    Authors:
    Szcześniak KA, Ciecierska A, Ostaszewski P, Chodkowska K, Sadkowski T.
    Conference:
    XXVI Kongresu Polskiego Towarzystwa Fizjologicznego (rok: 2014, ), Wydawca: Journal of Physiology and Pharmacology
    Data:
    konferencja 18.09-20.09
    Status:
    Published
  6. Effect of gamma-oryzanol on miRNA expression in differentiating equine skeletal muscle satellite cells.
    Authors:
    Chodkowska KA, Ciecierska A., Ostaszewski P, Szcześniak K, Sadkowski T.
    Conference:
    International Scientific Conference Molecular Research in Animal Science" (rok: 2014, ), Wydawca: Uniwersytet Rolniczy im. Hugona Kołłątaja w Krakowie
    Data:
    konferencja 09.06-10.06
    Status:
    Published
  7. Effect of β-hydroxy-β-methylbutyrate on hydrogen peroxide-induced injury in differentiating equine satellite cells - transcriptome profiling
    Authors:
    K.A. Chodkowska, A. Ciecierska, P. Ostaszewski, K. Szcześniak, T. Sadkowski
    Conference:
    Physiology and Biochemistry in Animal Nutrition (rok: 2015, ), Wydawca: The Kielanowski Institute of Animal Physiology and Nutrition, PAS
    Data:
    konferencja 23-24 września
    Status:
    Published
  8. Effect of β-hydroxy-β-methylbutyrate on miRNA expression in differentiating equine satellite cells exposed to hydrogen peroxide
    Authors:
    Karolina A. Chodkowska, Anna Ciecierska, Piotr Ostaszewski, Katarzyna Szcześniak, Tomasz Sadkowski
    Conference:
    1st World Conference on Innovative Animal Nutrition and Feeding (WIANF) (rok: 2015, ), Wydawca: 1st World Conference on Innovative Animal Nutrition and Feeding (WIANF)
    Data:
    konferencja 15-17 październik
    Status:
    Published
  9. Effect of β-hydroxy-β-methylbutyrate on transcriptomic profile in differentiating equine satellite cells
    Authors:
    Szcześniak K., Ciecierska A., Ostaszewski P., Chodkowska K., Sadkowski T.
    Conference:
    International Scientific Conference Molecular Research in Animal Science" (rok: 2014, ), Wydawca: Uniwersytet Rolniczy im. Hugona Kołłątaja w Krakowie
    Data:
    konferencja 09.06-10.06
    Status:
    Published

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