Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Structural and functional characterization of peptidyl prolyl isomerases - universally conserved protein folding catalysts

2011/03/B/NZ1/02825

Keywords:

PPIase immunophilins FKBPs parvulin PpiD SlyD cyclophilins synthetic lethality

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry
  • NZ2_1: Molecular genetics

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Politechnika Gdańska, Wydział Chemiczny

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Satish Raina 

Number of co-investigators in the project: 5

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 453 511 PLN

Project start date (Y-m-d): 2012-08-02

Project end date (Y-m-d): 2015-08-01

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. autoklaw przenośny (10 086 PLN)
  2. pH-metr.
  3. waga analityczna o wysokiej czujności.
  4. wytrząsarka (20 000 PLN)
  5. Sprzęt do rozdziału 2D do żeli IEF (31 380 PLN)
  6. blok termiczny z wytrząsaniem i vortex (15 000 PLN)
  7. inkubator mikrobiologiczny z chłodzeniem.
  8. inkubator (15 000 PLN)
  9. transiluminator UV z dwoma długościami fal (5 332 PLN)
  10. wirówka (20 000 PLN)
  11. wytrząsarka z regulacją temperaturą.

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (8)
  1. Multiple transcriptional factors regulate transcription of the rpoE gene in Escherichia coli under different growth conditions and when the lipopolysaccharide biosynthesis is defective
    Authors:
    Klein G, Stupak A, Biernacka D, Wojtkiewicz P, Lindner B, Raina S
    Academic press:
    Journal of Biological Chemistry (rok: 2016, tom: 291, strony: 22999-23019), Wydawca: American Society for Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1074/jbc.M116.748954 - link to the publication
  2. Molecular and structural basis of inner core lipopolysaccharide alterations in Escherichia coli: incorporation of glucuronic acid and phosphoethanolamine in the heptose region
    Authors:
    Klein G, Müller-Loennies S, Lindner B, Kobylak N, Brade H, Raina S
    Academic press:
    Journal of Biological Chemistry (rok: 2013, tom: 288, strony: 8111-8127), Wydawca: American Society for Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1074/jbc.M112.445981 - link to the publication
  3. Assembly of lipopolisaccharide in Escherichia coli requires the essential LapB heat shock protein
    Authors:
    Klein G, Kobylak N, Lindner B, Stupak A, Raina S
    Academic press:
    Journal of Biological Chemistry (rok: 2014, tom: 289, strony: 14829-14853), Wydawca: American Society for Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1074/jbc.M113.539494 - link to the publication
  4. Regulated control of the assembly and diversity of LPS by non-coding sRNAs
    Authors:
    Klein G, Raina S
    Academic press:
    BioMed Research International (rok: 2015, tom: 2015, strony: 153561), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2015/153561 - link to the publication
  5. Regulated structural alterations and the assembly of LPS
    Authors:
    Klein G, Gorzelak, P, Raina S
    Academic press:
    Molecular Microbiology , Wydawca: Wiley
    Status:
    Submitted
    DOI:
    brak - link to the publication
  1. Assembly of LPS: Essential role of new proteins LprA, LprB and a new sRNA slrA
    Authors:
    Raina S, Klein G
    Conference:
    EMBO/EMBL Symposium New Approaches and Concepts in Microbiology (rok: 2013, ), Wydawca: EMBO/EMBL
    Data:
    konferencja October 14-16
    Status:
    Published
  2. Functional characterisation of cytoplasmic peptide-prolyl cis/trans isomerases in Escherichia coli
    Authors:
    Raina S, Klein G
    Conference:
    International Symposium of Research Centre for Thermotolerant Microbial Resources in Yamaguchi (rok: 2015, ), Wydawca: University of Yamaguchi, Japan
    Data:
    konferencja March 6-9
    Status:
    Published
  3. New insights in the regulatory RNA mediated assembly of the outer membrane in Escherichia coli
    Authors:
    Raina S, Klein G
    Conference:
    3rd Conference on Regulating with RNA in Bacteria (rok: 2013, ), Wydawca: Institute for Molecular Infection Biology
    Data:
    konferencja June 4-8
    Status:
    Published
  4. Catalysis of protein folding by cytoplasmic peptidyl-prolyl isomerases
    Authors:
    Kobylak N, Klein G, Fischer G, Raina S
    Conference:
    ESF-EMBO Symposium Bacterial Networks (bacnet 13) (rok: 2013, ), Wydawca: ESF Reserach Conferences
    Data:
    konferencja March 16-21
    Status:
    Published
  5. Assembly of the outer membrane in Escherichia coli requires a new essential heat shock protein LapB and modulation by a new sRNA slrA
    Authors:
    Raina S, Klein G
    Conference:
    3rd Mol Micro Meeting (rok: 2014, ), Wydawca: Institute for Molecular Infection Biology
    Data:
    konferencja May 7-9
    Status:
    Published
  6. Functional characterization of cytoplasmic peptidyl isomerases: substrate identification and their recognition
    Authors:
    Klein G, Gorzelak P, Stupak A, Fischer G, Raina S
    Conference:
    EMBO Conference: The Biology of Molecular Chaperones (rok: 2015, ), Wydawca: EMBO
    Data:
    konferencja May 8-13
    Status:
    Published
  7. Transcriptional regulation of RpoE sigma factor - sensing of endotoxin alterations
    Authors:
    Klein G, Raina S
    Conference:
    ESF-EMBO Symposium Bacterial Networks (bacnet 13) (rok: 2013, ), Wydawca: ESF Reserach Conferences
    Data:
    konferencja March 16-21
    Status:
    Published
  8. Outer membrane assembly by new chaperones LprA and LprB
    Authors:
    Raina S, Linder B, Klein G
    Conference:
    ESF-EMBO Symposium Bacterial Networks (bacnet 13) (rok: 2013, ), Wydawca: ESF Reserach Conferences
    Data:
    konferencja March 16-21
    Status:
    Published

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