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Determination of a role of thiamine in the response of budding yeasts Saccharomyces cerevisiae to environmental stress conditions, with the emphasis on intra- and extracellular transport systems and molecular regulatory mechanisms.

2011/03/N/NZ1/01305

Keywords:

vitamin B1 abiotic stress yeast thiamine biosynthesis thiamine transport TDP-dependent enzymes antioxidative defense regulatory systems

Descriptors:

  • NZ1_10: Microbiology
  • NZ1_2: Biochemistry
  • NZ1_9: Biotechnology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Natalia Wolak 

Number of co-investigators in the project: 2

Call: PRELUDIUM 2 - announced on 2011-09-15

Amount awarded: 116 560 PLN

Project start date (Y-m-d): 2012-09-17

Project end date (Y-m-d): 2014-09-16

Project duration:: 24 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Pipeta elektroniczna wielomiarowa Gilson Concept C100 (2 200 PLN)
  2. Wielofunkcyjna uniwersalna wytząsarka PSU-20i z dodatkową platformą (5 800 PLN)
  3. Zestaw pipet automatycznych Discovery (D10, D20, D200, D1000) (1 600 PLN)
  4. Mikrowirówka z vortexem FVL-2400N (1 400 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (4)
  1. Thiamine increases the resistance of baker's yeast Saccharomyces cerevisiae against oxidative, osmotic and thermal stress, through mechanisms partly independent of thiamine diphosphate-bound enzymes.
    Authors:
    Wolak N, Kowalska E, Kozik A, Rapala-Kozik M
    Academic press:
    FEMS Yeast Research (rok: 2014, tom: 14(8), strony: 1249-62), Wydawca: John Wiley & Sons Ltd.
    Status:
    Published
    DOI:
    10.1111/1567-1364.12218. - link to the publication
  2. Characterization of thiamine uptake and utilization in Candida spp. subjected to oxidative stress.
    Authors:
    Wolak N, Tomasi M, Kozik A, Rapala-Kozik M
    Academic press:
    Acta Biochimica Polonica (rok: 2015, tom: 62(3), strony: 445-55), Wydawca: Polish Biochemical Society and the Committee of Biochemistry and Biophysics of the Polish Academy of Sciences
    Status:
    Published
    DOI:
    10.18388/abp.2015_1044 - link to the publication
  1. The effect of external thiamine on the antioxidative potential of baker's yeast Saccharomyces cerevisiae under abiotic stress conditions
    Authors:
    Wolak N, Rapala-Kozik M
    Conference:
    38th FEBS Congress (rok: 2013, ), Wydawca: John Wiley & Sons, Inc.
    Data:
    konferencja 6-11 lipca 2013
    Status:
    Published
    DOI:
    link to the publication
  2. Comparative study of the response against oxidative stress in benign and pathogenic yeasts and its modulation by therapeutic doses of thiamine
    Authors:
    Wolak N, Tomasi M, Rapala-Kozik M, Kozik A
    Conference:
    8. Międzynarodowa Konferencja "Thiamine Biochemistry" (rok: 2014, ), Wydawca: GIGA, Liege
    Data:
    konferencja 23-26 maja 2014
    Status:
    Published
  3. Identification of the main regulatory factors involved in the protective role of thiamine in baker's yeast Saccharomyces cerevisiae under stress conditions
    Authors:
    Wolak N, Kozik A, Rapala-Kozik M
    Conference:
    The FEBS EMBO 2014 Conference (rok: 2014, ), Wydawca: John Wiley & Sons, Inc.
    Data:
    konferencja 30 sierpnia - 4 września 2014
    Status:
    Published
    DOI:
    link to the publication
  4. Involvement of thiamine transport system in the response of budding yeast Saccharomyces cerevisiae to oxidative stress
    Authors:
    Wolak N, Kozik A, Rapala-Kozik M
    Conference:
    12th EUROPEAN CONFERENCE ON FUNGAL GENETICS (rok: 2014, ), Wydawca: ECFG12
    Data:
    konferencja 23-27 marca 2014
    Status:
    Published

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