Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Sequence preferences of ribonucleases involved in human microRNA biogenesis.

2011/03/B/NZ1/03259

Keywords:

Drosha cleavages Dicer cleavages sequence specificity mutant precursors miRNA 5' end bias

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry
  • NZ1_4: Structural biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

INSTYTUT CHEMII BIOORGANICZNEJ PAN W POZNANIU

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Włodzimierz Krzyżosiak 

Number of co-investigators in the project: 6

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 910 000 PLN

Project start date (Y-m-d): 2012-08-17

Project end date (Y-m-d): 2015-08-16

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. zestaw komputerowy (5 000 PLN)
  2. Notebook.
  3. aparat do elektroforezy (10 000 PLN)
  4. aparat do transferu białek.
  5. wirówka z rotorami (45 000 PLN)

Information in the final report

  • Publication in academic press/journals (9)
  1. The panorama of miRNA-mediated mechanisms in mammalian cells.
    Authors:
    Stroynowska-Czerwinska A, Fiszer A, Krzyzosiak WJ.
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2014, tom: 71, strony: 2253-2270), Wydawca: SPRINGER BASEL AG, PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
    Status:
    Published
    DOI:
    10.1007/s00018-013-1551-6 - link to the publication
  2. Cooperation meets competition in microRNA-mediated DMPK transcript regulation.
    Authors:
    Koscianska E, Witkos TM, Kozlowska E, Wojciechowska M, Krzyzosiak WJ
    Academic press:
    Nucleic Acids Research (rok: 2015, tom: 43, strony: 9500-18), Wydawca: OXFORD UNIV PRESS
    Status:
    Published
    DOI:
    10.1093/nar/gkv849 - link to the publication
  3. RNA imaging in living cells – methods and applications
    Authors:
    Martyna O Urbanek, Paulina Galka-Marciniak, Marta Olejniczak & Wlodzimierz J Krzyzosiak
    Academic press:
    RNA Biology (rok: 2014, tom: 11, strony: 1083-1095), Wydawca: LANDES BIOSCIENCE, 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA
    Status:
    Published
    DOI:
    10.4161/rna.35506 - link to the publication
  4. Sequence Features of Drosha and Dicer Cleavage Sites Affect the Complexity of IsomiRs
    Authors:
    Julia Starega-Roslan, Tomasz M. Witkos, Paulina Galka-Marciniak, Wlodzimierz J. Krzyzosiak
    Academic press:
    International Journal of Molecular Sciences (rok: 2015, tom: 16, strony: 8110-8127), Wydawca: MDPI AG
    Status:
    Published
    DOI:
    10.3390/ijms16048110 - link to the publication
  5. Small RNA Detection by in Situ Hybridization Methods
    Authors:
    Martyna O. Urbanek, Anna U. Nawrocka, Wlodzimierz J. Krzyzosiak
    Academic press:
    International Journal of Molecular Sciences (rok: 2015, tom: 16, strony: 13259-13286), Wydawca: MDPI AG
    Status:
    Published
    DOI:
    10.3390/ijms160613259 - link to the publication
  6. Characterization of a naturally occurring truncated Dicer
    Authors:
    Nicola Mosca, Julia Starega-Roslan, Filomena Castiello, Aniello Russo, Wlodzimierz J. Krzyzosiak, Nicoletta Potenza
    Academic press:
    Molecular Biology Reports (rok: 2015, tom: 42, strony: 1333-1340), Wydawca: SPRINGER
    Status:
    Published
    DOI:
    10.1007/s11033-015-3878-6 - link to the publication
  7. Nucleotide sequence of miRNA precursor contributes to cleavage site selection by Dicer
    Authors:
    Julia Starega-Roslan, Paulina Galka-Marciniak, Wlodzimierz J. Krzyzosiak
    Academic press:
    Nucleic Acids Research (rok: 2015, tom: 43, strony: 10939-51), Wydawca: OXFORD UNIV PRESS
    Status:
    Published
    DOI:
    10.1093/nar/gkv968 - link to the publication
  8. Regulation of Huntingtin Gene Expression by miRNA-137, -214, -148a, and Their Respective isomiRs
    Authors:
    Emilia Kozlowska, Wlodzimierz J. Krzyzosiak, Edyta Koscianska
    Academic press:
    International Journal of Molecular Sciences (rok: 2013, tom: 14, strony: 16999-17016), Wydawca: MDPI AG
    Status:
    Published
    DOI:
    10.3390/ijms140816999 - link to the publication
  9. Current understanding of the role of microRNAs in spinocerebellar ataxias
    Authors:
    Edyta Koscianska and Wlodzimierz J Krzyzosiak
    Academic press:
    Cerebellum & Ataxias (rok: 2014, tom: 1, strony: 7), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/2053-8871-1-7 - link to the publication

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