Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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New phosphino derivatives of chinolone antibiotics and their complexes with copper (I) and copper (II) ions. Determination of physicochemical properties and biological activity in the search of new therapeutic agents.

2011/03/B/ST5/01557

Keywords:

antibiotics chinolones phosphino derivatives copper complexes biological activity

Descriptors:

  • ST5_16:
  • ST5_11: Smart materials – self assembled materials, external stimuli-responsive materials
  • ST5_14: Other related subjects

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Wrocławski, Wydział Chemii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Małgorzata Jeżowska-Bojczuk 

Number of co-investigators in the project: 5

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 485 000 PLN

Project start date (Y-m-d): 2012-08-21

Project end date (Y-m-d): 2015-08-20

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komputer wraz z oprogramowaniem do obliczeń metodami mechaniki molekularnej (molecular docking). (12 000 PLN)
  2. Spektrofluorymetr Cary Eclipse termostatowany ogniwem Peltiera z przystawką typu "stopped-flow" (200 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. Phosphine derivatives of ciprofloxacin and norfloxacin, a new class of potential therapeutic agents
    Authors:
    Aleksandra Bykowska, Radosław Starosta, Urszula K. Komarnicka, Zbigniew Ciunik, Agnieszka Kyzioł, Katarzyna Guz-Regner, Gabriela Bugla-Płoskońska and Małgorzata Jeżowska-Bojczuk
    Academic press:
    New Journal of Chemistry (rok: 2014, tom: 38, strony: 1062-1071), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/C3NJ01243C - link to the publication
  2. Phosphine derivatives of sparfloxacin- synthesis, structures and in vitro activity.
    Authors:
    Urszula K. Komarnicka, Radosław Starosta, Katarzyna Guz-Regner, Gabriela Bugla-Płoskońska, Agnieszka Kyzioł, Małgorzata Jeżowska-Bojczuk
    Academic press:
    Journal of Molecular Structure (rok: 2015, tom: 1096, strony: 55-63), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molstruc.2015.04.044 - link to the publication
  3. Synthesis, properties and biological activity of a novel phosphines ligand derived from ciprofloxacin
    Authors:
    Aleksandra Bykowska, Radosław Starosta, Anna Brzuszkiewicz, Barbara Bażanów, Magdalena Florek, Natalia Jackulak, Jarosław Król, Jakub Grzesiak, Krzysztof Kaliński, Małgorzata Jeżowska-Bojczuk
    Academic press:
    Polyhedron (rok: 2013, tom: 60, strony: 23-29), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.poly.2013.04.059 - link to the publication
  4. Coordination versatility of phosphine derivatives of fluoroquinolones. New CuI and CuII complexes and their interactions with DNA.
    Authors:
    Aleksandra Bykowska, Radosław Starosta, Julia Jezierska, Małgorzata Jeżowska-Bojczuk
    Academic press:
    RSC Advances (rok: 2015, tom: 5, strony: 80804-80815), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/C5RA07483E - link to the publication
  5. Copper(I) complexes with phosphine derived from sparfloxacin. Part I – structures, spectroscopic properties and cytotoxicity.
    Authors:
    Urszula K. Komarnicka, Radosław Starosta, Agnieszka Kyzioł, Małgorzata Jeżowska-Bojczuk
    Academic press:
    Dalton Transactions (rok: 2015, tom: 44, strony: 12688-12699), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/C5DT01146A - link to the publication
  6. New copper(I) complexes bearing lomefloxacin motif: spectroscopic properties, in vitro cytotoxicity and interactions with DNA and human serum albumin.
    Authors:
    U. K. Komarnicka, R. Starosta, A. Kyzioł, M. Płotek, M. Puchalska, and M. Jeżowska-Bojczuk
    Academic press:
    Dalton Trans. (rok: 2016, ), Wydawca: RSC
    Status:
    Submitted
    DOI:
    brak - link to the publication
  7. Copper(I) complexes with phosphine derived from sparfloxacin. Part II: a first insight into the cytotoxic action mode.
    Authors:
    Urszula K. Komarnicka, Radosław Starosta, Michał Płotek, Rodrigo F.M. de Almeida, Małgorzata Jeżowska-Bojczuk, Agnieszka Kyzioł
    Academic press:
    Dalton Transactions (rok: 2016, tom: 45, strony: 5052-5063), Wydawca: RSC
    Status:
    Accepted for publication
    DOI:
    10.1039/c5dt04011f - link to the publication

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