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Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Development of stereospecific phosphorylating agents containing nucleophilic catalytic groups

2011/03/B/ST5/03102

Keywords:

stereospecific phosphates H-phosphonates phosphorothioates phosphorylating reagents nucleophilic catalysis

Descriptors:

  • ST5_23:
  • ST5_18:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Instytut Chemii Bioorganicznej PAN

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Michał Sobkowski 

Number of co-investigators in the project: 5

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 301 500 PLN

Project start date (Y-m-d): 2012-08-29

Project end date (Y-m-d): 2016-02-28

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Wirówka laboratoryjna (5 000 PLN)
  2. Pompa próżniowa olejowa (15 000 PLN)
  3. Zestaw komputerowy (3 500 PLN)
  4. Pompa próżniowa membranowa z kontrolerem próżni (25 000 PLN)
  5. Program komputerowy ChemOffice (5 500 PLN)
  6. Program komputerowy Reference Manager (1 500 PLN)
  7. Chiralne kolumny HPLC (4 szt.) (38 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (6)
  1. Recent Advances in H-Phosphonate Chemistry. Part 2. Synthesis of C-Phosphonate Derivatives
    Authors:
    Sobkowski M., Kraszewski A., Stawiński J.
    Academic press:
    Topics in Current Chemistry (rok: 2015, tom: 361, strony: 179-216), Wydawca: Springer-Verlag
    Status:
    Published
    DOI:
    10.1007/128_2014_563 - link to the publication
  2. Recent Advances in H-Phosphonate Chemistry. Part 1. H-Phosphonate Esters: Synthesis and Basic Reactions
    Authors:
    Sobkowski M., Kraszewski A., Stawiński J.
    Academic press:
    Topics in Current Chemistry (rok: 2015, tom: 361, strony: 137-177), Wydawca: Springer-Verlag
    Status:
    Published
    DOI:
    10.1007/128_2014_562 - link to the publication
  3. Oxyonium phosphobetaines - unusually stable nucleophilic catalyst-phosphate complexes formed from H-phosphonates and N-oxides
    Authors:
    M.Materna, J. Stawiński, A.Kiliszek, W.Rypniewski, M.Sobkowski
    Academic press:
    RSC Advances (rok: 2016, tom: 6(18), strony: 14448-14451), Wydawca: ROYAL SOC CHEMISTRY
    Status:
    Published
    DOI:
    10.1039/c5ra27465f - link to the publication
  4. The case of triethylammonium cation loss during purification of certain nucleotide analogues. A cautionary note
    Authors:
    Kolodziej,K.; Romanowska,J.; Stawinski,J.; Kraszewski,A.; Sobkowski,M.
    Academic press:
    Analytical and Bioanalytical Chemistry (rok: 2015, tom: 407, strony: 1775-1780), Wydawca: Springer-Verlag
    Status:
    Published
    DOI:
    10.1007/s00216-014-8397-0 - link to the publication
  5. Aryl H-Phosphonates 18. Synthesis, properties, and biological activity of 2 ',3 '-dideoxynucleoside (N-heteroaryl)phosphoramidates of increased lipophilicity
    Authors:
    K.Kołodziej, J.Romanowska, J.Stawiński, J.Boryski, A.Dąbrowska, A.lipniacki, A.Piasek, A.Kraszewski, M.Sobkowski
    Academic press:
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (rok: 2015, tom: 100, strony: 77-88), Wydawca: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2015.06.004 - link to the publication
  1. N-Oxides as Reagents in Nucleotide Chemistry
    Authors:
    Materna,M.; Stawinski,J.; Sobkowski,M.
    Conference:
    XVIth Symposium on Chemistry of Nucleic Acid Components (rok: 2014, ), Wydawca: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic
    Data:
    konferencja 8-14.06.2014
    Status:
    Published
  2. Oxidative dehalogenation of halogenophosphates by N-oxides in the synthesis of nucleotide analogues
    Authors:
    Materna,M.; Stawinski,J.; Sobkowski,M.
    Conference:
    XXI International Round Table on Nucleosides, Nucleotides and Nucleic Acids. Chemical Biology of Nucleic Acids (rok: 2014, ), Wydawca: BOKiZ
    Data:
    konferencja 24-28.08.2014
    Status:
    Published
  3. N-Oxides in the synthesis of nucleotide analogue
    Authors:
    Materna,M.; Stawinski,J.; Sobkowski,M.
    Conference:
    XXI International Round Table on Nucleosides, Nucleotides and Nucleic Acids. Chemical Biology of Nucleic Acids (rok: 2014, ), Wydawca: BOKiZ
    Data:
    konferencja 24-28.08.2014
    Status:
    Published
  4. Trialkylamine N-Oxides as Reagents in Nucleotide Chemistry
    Authors:
    M. Materna, J. Stawinski, M. Sobkowski
    Conference:
    XVIth Symposium on Chemistry of Nucleic Acid Components (rok: 2014, ), Wydawca: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic
    Data:
    konferencja 8-13.06.2014
    Status:
    Published
  5. Trialkylamine N-oxides in nucleotide chemistry
    Authors:
    Materna,M.; Stawinski,J.; Sobkowski,M.
    Conference:
    XXI International Round Table on Nucleosides, Nucleotides and Nucleic Acids. Chemical Biology of Nucleic Acids (rok: 2014, ), Wydawca: BOKiZ
    Data:
    konferencja 24-28.08.2014
    Status:
    Published
  6. Zastosowanie N-tlenków w syntezie analogów nukleotydów
    Authors:
    Materna,M.; Stawinski,J.; Sobkowski,M.
    Conference:
    58 Zjazd Naukowy Polskiego Towarzystwa Chemicznego (rok: 2015, ), Wydawca: Polskie Towarzystwo Chemiczne
    Data:
    konferencja 21-25.09.2015
    Status:
    Published
    DOI:
    link to the publication

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