Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

DHA/EPA and changes of peripheral blood cell epigenetics as well as the level of endothelial and pancreatic beta cell specific miRNA.

2011/02/A/NZ2/00022

Keywords:

epigenetic metabolic syndrome diabetes type 2

Descriptors:

  • NZ1_1: Molecular biology
  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ5_5: Diagnostics in human diseases

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydzial Lekarski

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Aldona Dembińska-Kieć 

Number of co-investigators in the project: 18

Call: MAESTRO 1 - announced on 2011-06-15

Amount awarded: 2 824 000 PLN

Project start date (Y-m-d): 2012-06-06

Project end date (Y-m-d): 2015-12-06

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. płuczka do płytek 96-dołkowych (1 840 PLN)
  2. termocykler (25 000 PLN)
  3. system do oczyszczania wody (20 000 PLN)
  4. wirówka wortex z rotorem (5 000 PLN)
  5. zamrażarka niskotemperaturowa z wyposażeniem (50 000 PLN)
  6. zestaw pipet (6 663 PLN)
  7. sonifikator z wposażeniem (20 000 PLN)

Information in the final report

  • Publication in academic press/journals (9)
  • Articles in post-conference publications (25)
  1. Enhanced GIP secretion in obesity is associated with biochemical alterations and miRNA contributing to the development of liver steatosis
    Authors:
    Joanna Goralska; Urszula Raźny; Anna Polus; Agnieszka Dziewońska; Anna Gruca; Anna Zdzienicka; Aldona Dembińska-Kieć; Bogdan Solnica; Agnieszka Micek; Maria Kapusta; Krystyna SłowińskaSolnica; Malgorzata Malczewska-Malec
    Academic press:
    BBA - Molecular Basis of Disease (rok: 2019, ), Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    brak - link to the publication
  2. Effect of insulin resistance on whole blood mRNA and microRNA expression affecting bone turnover
    Authors:
    Urszula Razny, Anna Polus, Joanna Goralska, Anna Zdzienicka, Anna Gruca, Maria Kapusta, Maria Biela, Aldona Dembinska-Kiec, Bogdan Solnica and Malgorzata Malczewska-Malec
    Academic press:
    European Journal of Endocrinology (rok: 2019, tom: 181, strony: 525-537), Wydawca: Bioscientifica Ltd
    Status:
    Published
    DOI:
    10.1530/EJE-19-0542 - link to the publication
  3. DNA methylation microarrays identify epigenetically regulated genes in obese patients with hypercholesterolemia
    Authors:
    Teresa Płatek, Anna Polus, Joanna Góralska, Urszula Raźny, Anna Gruca, Beata Kiec-Wilk, Piotr Zabielski, Maria Kapusta, Krystyna Słowińska-Solnica, Bogdan Solnica, Małgorzata Malczewska-Malec, Aldona Dembińska-Kieć
    Academic press:
    Journal of Steroid Biochemistry and Molecular Biology (rok: 2019, ), Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    brak - link to the publication
  4. The patterns of histone acetylation in type 2 diabetes mellitus; a whole genome study
    Authors:
    Barbara Zapała, Monika Piwowar, Wiktor Jurkowski, Urszula Ciałowicz, Agnieszka Dziewońska, Jan Koper, Bogdan Solnica, Aldona Dembińska-Kieć
    Academic press:
    Clinical Epigenetics - Endocrinology and Metabolic Epigenetics (rok: 2019, ), Wydawca: BMC
    Status:
    Submitted
    DOI:
    brak - link to the publication
  5. Carboxylated and undercarboxylated osteocalcin in metabolic complications of human obesity and prediabetes.
    Authors:
    Razny U, Fedak D, Kiec-Wilk B, Goralska J, Gruca A, Zdzienicka A, Kiec-Klimczak M, Solnica B, Hubalewska-Dydejczyk A, Malczewska-Malec M
    Academic press:
    Diabetes Metab Res Rev (rok: 2017, tom: 33(3), strony: 45302), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/dmrr.2862 - link to the publication
  6. Omega-3 fatty acid supplementation influences the whole blood transcriptome in women with obesity, associated with pro-resolving lipid mediator production
    Authors:
    Polus A, Zapala B, Razny U, Gielicz A, Kiec-Wilk B, Malczewska-Malec M, Sanak M, Childs CE, Calder PC, Dembinska-Kiec A.
    Academic press:
    Biochim Biophys Acta. Mol. Cell Biol. Lipids (rok: 2016, tom: 1861(11), strony: 1746-1755), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbalip.2016.08.005 - link to the publication
  7. Effect of caloric restriction with or without n-3 polyunsaturated fatty acids on insulin sensitivity in obese subjects: A randomized placebo controlled trial
    Authors:
    Urszula Razny, Beata Kiec-Wilk, AnnaPolus, Joanna Goralska, Malgorzata Malczewska-Malec, Dominika Wnek, Anna Zdzienicka, Anna Gruca, Caroline E. Childs, Maria Kapusta, Krystyna Slowinska-Solnica, Philip C.Calder, Aldona Dembinska-Kieć
    Academic press:
    BBA Clinical (rok: 2015, tom: 4, strony: 45486), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbacli.2015.05.001 - link to the publication
  8. Pro-inflammatory gene expression profile in obese adults with high plasma GIP levels.
    Authors:
    Góralska J, Raźny U, Polus A, Stancel-Możwiłło J, Chojnacka M, Gruca A, Zdzienicka A, Dembińska-Kieć A, Kieć-Wilk B, Solnica B, Malczewska-Malec M
    Academic press:
    Int J Obes (rok: 2017, tom: 45639, strony: 45319), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/ijo.2017.305 - link to the publication
  9. Relation of the protein glycation, oxidation and nitration to the osteocalcin level in obese subjects.
    Authors:
    Razny U, Goralska J, Zdzienicka A, Fedak D, Masania J, Rabbani N, Thornalley P, Pawlica-Gosiewska D, Gawlik K, Dembinska-Kiec A, Solnica B, Malczewska-Malec M
    Academic press:
    Acta Biochim Pol. (rok: 2017, tom: 64(3), strony: 415-422), Wydawca: The Journal of the Polish Biochemical Society and of the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Status:
    Published
    DOI:
    10.18388/abp.2017_1627 - link to the publication
  1. Anti-inflammatory effect of n-3 PUFA supplementation in subjects with obesity and type 2 diabetes.
    Authors:
    Raźny U., Kieć-Wilk B., Góralska J., Polus A., Zapała B., Chojnacka M., Malczewska-Malec M., Malec M., Dembińska-Kieć A.
    Conference:
    The HARC Conference on Translational Research in Healthy Ageing., Łódź, Poland (rok: 2015, ), Wydawca: The HARC Conference on Translational Research in Healthy Ageing., Łódź, Poland
    Data:
    konferencja 16-18 kwiecień
    Status:
    Published
  2. Incretin mimetic exendin-4 influence the bioenergetics of human adipocytes.
    Authors:
    Góralska J., Śliwa A., Chojnacka M., Polus A., Gruca A., Raźny U., Kiec-Klimczak M., Kieć-Wilk B., Dembińska-Kieć A.
    Conference:
    49th Meetting of the Polish Biochemical Society, 12th Conference of the Polish Society for Cell Biology, 16th Meeting of the Polish Biophysical Society, 7th Meeting of the Polish Bioinformatics Society, (rok: 2014, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 9-12 wrzesnia
    Status:
    Published
  3. Relationships of GIP with liver function – Effects of caloric restriction and n-3PUFA supplementation.
    Authors:
    Malczewska-Malec M, Góralska J., Raźny U., Kieć-Wilk B., Solnica B., Stancel-Możwiłło J., Dembińska-Kiec A.
    Conference:
    83rd EAS Congress, Glasgow, UK (rok: 2015, ), Wydawca: Atherosclerosis
    Data:
    konferencja 22-25 marca
    Status:
    Published
    DOI:
    link to the publication
  4. Supplementation of the low-calorie diet with n-3 PUFA significantly improves plasma lipid profile depending on the GIP level
    Authors:
    Góralska J., Malczewska-Malec M, Raźny U., Zdzienicka A., Kieć-Wilk B.,Zabielski P., Chabowski A., Dembińska-Kiec A.
    Conference:
    17th International Symposium on Atherosclerosis. ISA 2015. Netherlands, Amsterdam, (rok: 2015, ), Wydawca: 17th International Symposium on Atherosclerosis. ISA 2015. Netherlands, Amsterdam,
    Data:
    konferencja 23-26-maja
    Status:
    Published
  5. The effect of EPA/DHA suppelmentation on postprandial triglyceride and insulin concentration in obesity.
    Authors:
    Raźny U., Malczewska-Malec M., Góralska J., Zdzienicka A., Stancel-Możwiłło J., Childs C., Calder C., Gruca A., Dembińska-Kieć A
    Conference:
    Nutritionally and clinically relevent emerging biomarkers (rok: 2014, ), Wydawca: Medical University of Graz
    Data:
    konferencja 27-28 marca
    Status:
    Published
  6. Anti-inflammatory effects of n-3 PUFA supplementation in obesity.
    Authors:
    Góralska J., Raźny U., Kiec-Wilk B., Malczewska-Malec M., Polus A., Zdzienicka A., Wnek D., Gruca A., Stancel-Mozwillo J., Malecki M
    Conference:
    EAS Congress (rok: 2014, ), Wydawca: EAS
    Data:
    konferencja 31 maja-3 czerwca
    Status:
    Published
  7. Selected nutrient responsive biomarkers of metabolic syndrome.
    Authors:
    Malczewska-Malec M., Raźny U., Góralska J., Kieć -Wilk B., Solnica B., Dembińska-Kieć A.,
    Conference:
    Biomarkers and Health claims on food Bioclaims Meeting with Stakeholders, Palma de Mallorca, Spain (rok: 2015, ), Wydawca: Biomarkers and Health claims on food Bioclaims Meeting with Stakeholders, Palma de Mallorca, Spain
    Data:
    konferencja 12-13 luty
    Status:
    Published
  8. Anti-inflammatory effects of transcellular EPA and DHA metabolites in prediabetes
    Authors:
    Polus A., Raźny U., Śliwa A., Gielicz A., Zapała B., Sanak M., Calder P., Dembińska-Kieć A.,
    Conference:
    Biomarkers and Health claims on food Bioclaims Meeting with Stakeholders, Palma de Mallorca, Spain (rok: 2015, ), Wydawca: Biomarkers and Health claims on food Bioclaims Meeting with Stakeholders, Palma de Mallorca, Spain
    Data:
    konferencja 12-13 luty
    Status:
    Published
  9. Carboxylated and undercarboxylated osteocalcin as the marker of metabolic complications of human obesity.
    Authors:
    Zdzienicka A., Raźny U., Fedak D., Kieć-Wilk B., Góralska J., Malczewska-Malec M.
    Conference:
    17th International Symposium on Atherosclerosis. ISA 2015. Netherlands, Amsterdam, (rok: 2015, ), Wydawca: 17th International Symposium on Atherosclerosis. ISA 2015. Netherlands, Amsterdam,
    Data:
    konferencja 23-26 maja
    Status:
    Published
  10. Comparison of different compliance criteria in the evaluation of 3-months omega-3 PUFA supplementation study
    Authors:
    Uchman A., Childs C., Góralska J., Raźny U., Malczewska-Malec M., Calder P., Kieć-Wilk B.
    Conference:
    Doctoral Workshop on Molecular Nutrition (rok: 2014, ), Wydawca: Universitat Rovira i Virgili
    Data:
    konferencja 26-27 czerwca
    Status:
    Published
  11. Differences in plasma fatty acids profile in patients with diabetes Type 1 and diabetes Type 2.
    Authors:
    Góralska J., Kieć-Wilk B., Malczewska-Malec M., Raźny U., Zabielski P., Chabowski A., Zdzienicka A., Małecki M., Dembińska-Kieć A.
    Conference:
    The HARC Conference on Translational Research in Healthy Ageing., Łódź, Poland (rok: 2015, ), Wydawca: The HARC Conference on Translational Research in Healthy Ageing., Łódź, Poland
    Data:
    konferencja 16-18 kwiecień
    Status:
    Published
  12. Lipotoxic effect of free fatty acid in the in vitro model
    Authors:
    Śliwa A., Góralska J., Gruca A., Polus A., Ciałowicz U., Kieć-Wilk B., Dembińska-Kieć A:
    Conference:
    EBEC 2014 (rok: 2014, ), Wydawca: Biochimica et Biophysica Acta (BBA) – Bioenergetics
    Data:
    konferencja 12-17 lipca
    Status:
    Published
  13. The effect of n-3 PUFA supplementation on postprandial triglycerides and insulin in obesity
    Authors:
    Raźny U., Polus A., Wnęk D., Kieć-Wilk B., Śliwa A., Zdzienicka A., Gruca A.,Małecki M., Malczewska-Malec M.
    Conference:
    EAS Congress (rok: 2014, ), Wydawca: EAS
    Data:
    konferencja 31 maja-3 czerwca
    Status:
    Published
  14. The effect on-3 PUFA on markers of insulin resistance in prediabesity
    Authors:
    Polus A., Kieć-Wilk B., Malczewska-Malec M., Fedak D., Sanak M., Calder P. Dembińska-Kieć A
    Conference:
    Doctoral Workshop on Molecular Nutrition (rok: 2014, ), Wydawca: Universitat Rovira i Virgili
    Data:
    konferencja 26-27 czerwca
    Status:
    Published
  15. Anti-inflammatory effects of EPA and DHA supplementation. Correlation of changes in biochemical markers of low-grade systemic inflammatory during obesity with the expression of miRNAs
    Authors:
    Polus A., Razny U., Goralska J., Malczewska-Malec M., Wnek M, Kiec-Wilk B., Zdzienicka A., Dembinska-Kiec A.
    Conference:
    21th European Congress on Obesity (ECO 2014) (rok: 2014, ), Wydawca: S. Karger Medical and Scientific Publishers
    Data:
    konferencja 28-31 maja
    Status:
    Published
  16. Carboxylated and uncarboxylated osteocalcin as the marker of metabolic complications of human obesity and prediabetes.
    Authors:
    Raźny U., Malczewska-Malec M., Fedak D., Góralska J., Gruca A., Zdzienicka A., Kieć-Wilk B., Solnica B., Dembińska-Kieć A
    Conference:
    Biomarkers and Health claims on food Bioclaims Meeting with Stakeholders, Palma de Mallorca, Spain (rok: 2015, ), Wydawca: Biomarkers and Health claims on food Bioclaims Meeting with Stakeholders, Palma de Mallorca, Spain
    Data:
    konferencja 12-13 luty
    Status:
    Published
  17. Comparison of different compliance criteria in the evaluation of 3-months omega-3 PUFA supplementation study.
    Authors:
    Zdzienicka A., Childs C., Raźny U., Góralska J., Malczewska-Malec M., Calder P., Dembińska-Kiec A
    Conference:
    83rd EAS Congress, Glasgow, UK (rok: 2015, ), Wydawca: Atherosclerosis
    Data:
    konferencja 22-25 marca
    Status:
    Published
  18. Incretin mimetic exendin – 4 influence the bioenergetics of human adipocytes
    Authors:
    Góralska J., Śliwa A., Polus A., Chojnacka M., Raźny U., Gruca A., Zdzienicka A., Dembińska-Kieć A.
    Conference:
    EBEC 2014 (rok: 2014, ), Wydawca: Biochimica et Biophysica Acta (BBA) – Bioenergetics
    Data:
    konferencja 12-17 lipca
    Status:
    Published
  19. The new class of PUFA derivatives promoting resolution of inflammation
    Authors:
    Polus A., Kieć-Wilk B., Dembińska-Kiec A
    Conference:
    Nutritionally and clinically relevent emerging biomarkers" (rok: 2014, ), Wydawca: Medical University of Graz
    Data:
    konferencja 27-28 marca
    Status:
    Published
  20. miRNA and Anti-inflammatory effect of n-3 PUFA (DHA/EPA) in prediabetes.
    Authors:
    Polus A., Kieć-Wilk B., Czech U., Konovalova T/. Singruner A., Schmitz T., Dembińska-Kiec A.
    Conference:
    EAS Congress (rok: 2014, ), Wydawca: EAS
    Data:
    konferencja 31 maja-3 czerwca
    Status:
    Published
  21. GIP and lipids changes in obese patients supplementation with n-3 PUFA during caloric restriction.
    Authors:
    Góralska J., Malczewska-Malec M., Raźny U., Polus A., Zdzienicka A., Gruca A., Kapusta M., Kieć-Wilk B., Solnica B., Zabielski P., Chabowski A., Calder P., Małecki M., Dembińska-Kieć A.
    Conference:
    Biomarkers and Health claims on food Bioclaims Meeting with Stakeholders, Palma de Mallorca, Spain (rok: 2015, ), Wydawca: Biomarkers and Health claims on food Bioclaims Meeting with Stakeholders, Palma de Mallorca, Spain
    Data:
    konferencja 12-13 luty
    Status:
    Published
  22. Influence of caloric restriction and n- PUFAs supplementation on insulin sensivity in prediabetes
    Authors:
    Raźny U., Malczewska-Malec M., Góralska J., Zdzienicka A., Kieć-Klimczak M., Hubalewska-Dydejczyk A., Dembińska-Kieć A.
    Conference:
    49th Meetting of the Polish Biochemical Society, 12th Conference of the Polish Society for Cell Biology, 16th Meeting of the Polish Biophysical Society, 7th Meeting of the Polish Bioinformatics Society (rok: 2014, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 9-12 września
    Status:
    Published
  23. Is the Quantity or Quality of fasting blood FFAs responsible for the obesity complications? Biomarkers in Human Health and disease.
    Authors:
    Dembińska-Kieć A.
    Conference:
    1st Reunion Meeting of the BIOCLAIMS Consortium and 5th International Symposium of the Human Nutrition & Metabolism Research and Training Center. (rok: 2015, ), Wydawca: HNMRC
    Data:
    konferencja 9-10 October
    Status:
    Published
  24. Relationships of GIP secretion with plasma fatty acids profile in diabetic patients.
    Authors:
    Góralska J., Kieć-Wilk B., Malczewska-Malec M, Raźny U., Zabielski P., Chabowski A. Zdzienicka A., Solnica B., Małecki M., Dembińska-Kiec A
    Conference:
    83rd EAS Congress, Glasgow, UK (rok: 2015, ), Wydawca: Atherosclerosis
    Data:
    konferencja 22-25 marca
    Status:
    Published
  25. The n-3 PUFA supplementation in diabetes and obesity
    Authors:
    Anna Polus, Monika Piwowar, Wiktor Jurkowski, Małgorzata Malczewska-Malec, Beata Kieć-Wilk, Teresa Płatek, Monika Chojnacka, Barbara Zapała, Agnieszka Śliwa, Dominika Wnęk, Aldona Dembińska-Kieć
    Conference:
    Epigenetics, Obesity and Metabolism Conference EOM 2015 CAMBRIDGE, UK (rok: 2015, ), Wydawca: Epigenetics, Obesity and Metabolism Conference EOM 2015 CAMBRIDGE, UK
    Data:
    konferencja 11-14 październik
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy