Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Mechanisms of DNA replication regulation in prokaryotic and eukaryotic cells: are there general biological rules of the control of this process?

2011/02/A/NZ1/00009

Keywords:

DNA replication central carbon metabolism transcription flavonoids

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry
  • NZ2_1: Molecular genetics

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Gdański, Wydział Biologii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Grzegorz Węgrzyn 

Number of co-investigators in the project: 10

Call: MAESTRO 1 - announced on 2011-06-15

Amount awarded: 2 996 000 PLN

Project start date (Y-m-d): 2012-04-30

Project end date (Y-m-d): 2017-04-30

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Mikroskop optyczny do pozyskiwania i analizy obrazu fluorescencyjnego (250 000 PLN)
  2. Wirówka na małe objętości (15 000 PLN)
  3. Wirówka laboraroryjna (35 000 PLN)
  4. Zamrażarka niskotemperaturowa z wyposażeniem (70 000 PLN)
  5. Spektrofotometr (30 000 PLN)
  6. Wirówka z pompą do zatężania próbek (koncentrator) (30 000 PLN)
  7. Fotometr do biologii molekularnej (23 000 PLN)
  8. Wstrząsarka laboratoryjna z platformą uniwersalną (35 000 PLN)
  9. Łaźnia wodna (12 000 PLN)

Information in the final report

  • Publication in academic press/journals (13)
  • Book publications / chapters in book publications (1)
  1. Effects of flavonoids on expression of genes involved in cell cycle regulation and DNA replication in human fibroblasts
    Authors:
    Marta Moskot, Joanna Jakóbkiewicz-Banecka, Elwira Smolińska, Ewa Piotrowska, Grzegorz Węgrzyn, Magdalena Gabig-Cimińska
    Academic press:
    Molecular and Cellular Biochemistry (rok: 2015, tom: 407, strony: 97-109), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11010-015-2458-3 - link to the publication
  2. Mutations in central carbon metabolism genes suppress defects in nucleoid position and cell division of replication mutants in Escherichia coli
    Authors:
    Monika Maciąg-Dorszyńska, Małgorzata Ignatowska, Laurent Jannière, Grzegorz Węgrzyn, Agnieszka Szalewska-Pałasz
    Academic press:
    Gene (rok: 2012, tom: 503, strony: 31-35), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.gene.2012.04.066 - link to the publication
  3. Phenethyl isothiocyanate inhibits Shiga toxin production in enterohemorrhagic Escherichia coli by the stringent response induction
    Authors:
    Dariusz Nowicki, Monika Maciąg-Dorszyńska, Wioletta Kobiela, Anna Herman-Antosiewicz, Alicja Węgrzyn, Agnieszka Szalewska-Pałasz, Grzegorz Węgrzyn
    Academic press:
    Antimicrobial Agents and Chemotherapy (rok: 2014, tom: 58, strony: 2304-2315), Wydawca: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/AAC.02515-13 - link to the publication
  4. The model homologue of the partially defective human 5,10-methylenetetrahydrofolate reductase, considered as a risk factor for stroke due to increased homocysteine level, can be protected and reactivated by heat shock proteins
    Authors:
    Michał Grabowski, Bogdan Banecki, Leszek Kadziński, Joanna Jakóbkiewicz-Banecka, Magdalena Gabig-Cimińska, Alicja Węgrzyn, Grzegorz Węgrzyn, Zyta Banecka-Majkutewicz
    Academic press:
    Metabolic Brain Disease (rok: 2016, tom: 31, strony: 1041-1045), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11011-016-9844-8 - link to the publication
  5. ppGpp-dependent negative control of DNA replication of Shiga toxin-converting bacteriophages in Escherichia coli
    Authors:
    Dariusz Nowicki, Wioletta Kobiela, Alicja Węgrzyn, Grzegorz Węgrzyn, Agnieszka Szalewska-Pałasz
    Academic press:
    Journal of Bacteriology (rok: 2013, tom: 195, strony: 5007–5015), Wydawca: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/JB.00592-13 - link to the publication
  6. Cell cycle is disturbed in mucopolysaccharidosis type II fibroblasts, and can be improved by genistein
    Authors:
    . Marta Moskot, Magdalena Gabig-Cimińska, Joanna Jakóbkiewicz-Banecka, Magdalena Węsierska, Katarzyna Bocheńska, Grzegorz Węgrzyn
    Academic press:
    Gene (rok: 2016, tom: 585, strony: 100–103), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.gene.2016.03.029 - link to the publication
  7. Genistein inhibits activities of methylenetetrahydrofolate reductase and lactate dehydrogenase, enzymes which use NADH as a substrate
    Authors:
    Michał Grabowski, Bogdan Banecki, Leszek Kadziński, Joanna Jakóbkiewicz-Banecka, Rajmund Kaźmierkiewicz, Magdalena Gabig-Cimińska, Grzegorz Węgrzyn, Alicja Węgrzyn, Zyta Banecka-Majkutewicz
    Academic press:
    Biochemical and Biophyscial Research Communications (rok: 2015, tom: 465, strony: 363-367), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbrc.2015.08.004 - link to the publication
  8. Purified Stx and λ phages' initiator O proteins bind specifically to two different origins of replication in vitro
    Authors:
    Katarzyna I. Kozłowska, Joanna Tymecka-Mulik, Grzegorz Węgrzyn
    Academic press:
    Protein Expression and Purification (rok: 2016, tom: 131, strony: 16-26), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pep.2016.11.002 - link to the publication
  9. Replicating DNA by cell factories: roles of central carbon metabolism and transcription in the control of DNA replication in microbes, and implications for understanding this process in human cells
    Authors:
    Sylwia Barańska, Monika Glinkowska, Anna Herman-Antosiewicz, Monika Maciąg-Dorszyńska, Dariusz Nowicki, Agnieszka Szalewska-Pałasz, Alicja Węgrzyn, Grzegorz Węgrzyn
    Academic press:
    Microbial Cell Factories (rok: 2013, tom: 12, strony: 55), Wydawca: Springer-BioMed Central
    Status:
    Published
    DOI:
    10.1186/1475-2859-12-55 - link to the publication
  10. A dual promoter system regulating lambda DNA replication initiation
    Authors:
    Paweł Olszewski, Anna Szambowska, Sylwia Barańska, Magdalena Narajczyk, Grzegorz Węgrzyn, Monika Glinkowska
    Academic press:
    Nucleic Acids Research (rok: 2014, tom: 42, strony: 4450-4462), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gku103 - link to the publication
  11. Different effects of ppGpp on Escherichia coli DNA replication in vivo and in vitro
    Authors:
    Monika Maciąg-Dorszyńska, Agnieszka Szalewska-Pałasz, Grzegorz Węgrzyn
    Academic press:
    FEBS Open Bio (rok: 2013, tom: 3, strony: 161-164), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.fob.2013.03.001 - link to the publication
  12. Effects of partial silencing of genes coding for enzymes involved in glycolysis and tricarboxylic acid cycle on the enterance of human fibroblasts to the S phase
    Authors:
    Aleksandra Konieczna, Aneta Szczepańska, Karolina Sawiuk, Grzegorz Węgrzyn, Robert Łyżeń
    Academic press:
    BMC Cell Biology (rok: 2015, tom: 16, strony: 16), Wydawca: Springer-BioMed Central
    Status:
    Published
    DOI:
    10.1186/s12860-015-0062-8 - link to the publication
  13. Enzymes of the central carbon metabolism: are they linkers between transcription, DNA replication, and carcinogenesis?
    Authors:
    Aleksandra Konieczna, Aneta Szczepańska, Karolina Sawiuk, Robert Łyżeń, Grzegorz Węgrzyn
    Academic press:
    Medical Hypotheses (rok: 2015, tom: 84, strony: 58-67), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mehy.2014.11.016 - link to the publication
  1. DNA Replication Control in Microbial Cell Factories
    Authors:
    Monika Glinkowska, Lidia Boss, Grzegorz Węgrzyn
    Book:
    DNA Replication Control in Microbial Cell Factories (rok: 2015, tom: książka, strony: 50 stron), Wydawca: Springer
    Status:
    Published

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