Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Epidemiological and pathogenetic aspects of Primary Biliary Cirrhosis (PBC)

2011/02/A/NZ5/00321

Keywords:

primary biliary cirrhosis epidemiology pathogenesis cholestasis oxidative stress ademethionine chronic fatigue

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Pomorski Uniwersytet Medyczny w Szczecinie, Wydział Lekarski z Oddziałem Nauczania w Języku Angielskim

woj. zachodniopomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Piotr Milkiewicz 

Number of co-investigators in the project: 5

Call: MAESTRO 1 - announced on 2011-06-15

Amount awarded: 1 895 800 PLN

Project start date (Y-m-d): 2012-05-11

Project end date (Y-m-d): 2017-05-11

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komputer przenośny (notebook) (5 000 PLN)
  2. Szafa mroźnicza.
  3. Zamrażarka (40 000 PLN)
  4. Kriostat (70 000 PLN)
  5. Mikroskop świetlny z lampą fluorescencyjną (250 000 PLN)

Information in the final report

  • Publication in academic press/journals (10)
  • Articles in post-conference publications (7)
  1. TRAF1-C5 Affects Quality of Life in Patients with Primary Biliary Cirrhosis
    Authors:
    Joanna Raszeja-Wyszomirska, Ewa Wunsch, Agnieszka Kempinska-Podhorodecka, Daniel S. Smyk, Dimitrios P. Bogdanos, Malgorzata Milkiewicz, Piotr Milkiewicz
    Academic press:
    Clinical and Developmental Immunology (rok: 2013, tom: 2013 (2013), strony: 7), Wydawca: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2013/510547 - link to the publication
  2. Variant adiponutrin confers genetic protection against cholestatic itch
    Authors:
    Marcin Krawczyk, Malgorzata Milkiewicz, Hanns-Ulrich Marschall, Clemens Bartz, Frank Grunhage, Ewa Wunsch, Piotr Milkiewicz, Frank Lammert
    Academic press:
    Scientific Reports (rok: 2014, tom: 4, strony: 4), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/srep06374 - link to the publication
  3. Polymorphisms of IL12RB2 May Affect the Natural History of Primary Biliary Cholangitis: A Single Centre Study
    Authors:
    Urszula Wasik, Ewa Wunsch, Gary L. Norman, Eirini I. Rigopoulou, Dimitrios P. Bogdanos, Piotr Milkiewicz, Małgorzata Milkiewicz
    Academic press:
    Journal of Immunology Research (rok: 2017, tom: 2017, strony: 5 s., art. 2185083), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2017/2185083 - link to the publication
  4. Serum autotaxin is a marker of the severity of liver injury and overall survival in patients with cholestatic liver diseases
    Authors:
    Ewa Wunsch, Marcin Krawczyk, Małgorzata Milkiewicz, Jocelyn Trottier, Olivier Barbier, Markus F. Neurath, Frank Lammert, Andreas E. Kremer, Piotr Milkiewicz
    Academic press:
    Scientific Reports (rok: 2016, tom: 6, art. 30847, strony: 12 s.), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/srep30847 - link to the publication
  5. Decreased expression of vitamin D receptor affects an immune response in primary biliary cholangitis via the VDR-miRNA155-SOCS1 pathway.
    Authors:
    Agnieszka Kempińska-Podhorodecka, Małgorzata Milkiewicz, Urszula Wasik, Joanna Ligocka, Michał Zawadzki, Marek Krawczyk, Piotr Milkiewicz
    Academic press:
    International Journal of Molecular Sciences (rok: 2017, tom: 18 (2), art.289, strony: 15 s.), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/ijms18020289 - link to the publication
  6. Expression of hepatic Fibroblast Growth Factor 19 is enhanced in Primary Biliary Cirrhosis and correlates with severity of the disease.
    Authors:
    Ewa Wunsch, Małgorzata Milkiewicz, Urszula Wasik, Jocelyn Trottier, Agnieszka Kempińska-Podhorodecka, Elwyn Elias, Olivier Barbier, Piotr Milkiewicz
    Academic press:
    Scientific Reports (rok: 2015, tom: 5, strony: art. 13462, 13 s), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/srep13462 - link to the publication
  7. Liver Expression of Sulphotransferase 2A1 Enzyme Is Impaired in Patients with Primary Sclerosing Cholangitis: Lack of the Response to Enhanced Expression of PXR
    Authors:
    Ewa Wunsch, Marta Klak, Urszula Wasik, Malgorzata Milkiewicz, Malgorzata Blatkiewicz, Elzbieta Urasinska, Olivier Barbier, Dariusz Bielicki, Dimitrios P. Bogdanos, Elwyn Elias, Piotr Milkiewicz
    Academic press:
    Journal of Immunology Research (rok: 2015, tom: 2015,art.571353, strony: 8 s.), Wydawca: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2015/571353 - link to the publication
  8. Assessment of health related quality of life in polish patients with primary biliary cirrhosis
    Authors:
    Joanna Raszeja-Wyszomirska, Ewa Wunsch, Marek Krawczyk, Eirini I. Rigopoulou, Konrad Kostrzewa, Gary L. Norman, Dimitrios P. Bogdanos, Piotr Milkiewicz
    Academic press:
    Clinics and Research in Hepatology and Gastroenterology (rok: 2016, tom: vol. 40, nr 4, strony: 471-479), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.006 - link to the publication
  9. Protection against oxidative stress mediated by the Nrf2/Keap1 axis is impaired in Primary Biliary Cholangitis.
    Authors:
    Urszula Wasik, Małgorzata Milkiewicz, Agnieszka Kempińska-Podhorodecka, Piotr Milkiewicz
    Academic press:
    Scientific Reports (rok: 2017, tom: 7, art. 44769, strony: 9 s), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/srep44769 - link to the publication
  10. Ursodeoxycholic acid influences the expression of p27kip1 but not FoxO1 in patients with non-cirrhotic primary biliary cirrhosis
    Authors:
    Malgorzata Milkiewicz, Justyna Kopycińska, Agnieszka Kempińska-Podhorodecka, Tara Haas, Dimitrios P. Bogdanos, Elwyn Elias, Piotr Milkiewicz
    Academic press:
    Journal of Immunology Research (rok: 2014, tom: 2014: 921285, strony: 8), Wydawca: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2014/921285 - link to the publication
  1. Decreased expression of vitamin D receptor may affect an immune response via VDR - miRNA155 - SOCS1 pathway in primary biliary cirrhosis.
    Authors:
    Agnieszka Kempińska-Podhorodecka, Urszula Wasik, Piotr Milkiewicz, Małgorzata Milkiewicz.
    Conference:
    The International Liver Congress 2016 (rok: 2016, ), Wydawca: European Association for the Study of the Liver
    Data:
    konferencja 13-17.04.2016
    Status:
    Published
    DOI:
    link to the publication
  2. S-Adenosyl L-Methionine-induced protein S-glutathionylation may modulate immune responses in patients with primary biliary cholangitis
    Authors:
    Ewa Kilanczyk, Ewa Wunsch, Piotr Milkiewicz, Malgorzata Milkiewicz
    Conference:
    EASL Monothematic Conference: Cholangiocytes in health and disease (rok: 2017, ), Wydawca: European Association for the Study of the Liver
    Data:
    konferencja 9-11.06.2017
    Status:
    Published
  3. Adaptive mechanisms in chronic cholestasis in humans: changes in the expression of nuclear receptors and sulphotransferase 2A1
    Authors:
    Ewa Wunsch, Małgorzata Blatkiewicz, Marta Klak, Olivier Barbier, Dimitrios P. Bogdanos, Małgorzata Milkiewicz, Elwyn Elias, Piotr Milkiewicz
    Conference:
    EASL Monothematic Conference: Primary biliary cirrhosis (PBC) (rok: 2014, ), Wydawca: European Association for the Study of the Liver
    Data:
    konferencja 23-24.05.2014
    Status:
    Published
    DOI:
    link to the publication
  4. S-adenosyl-L-methionine improves quality of life and liver biochemistry in patients with primary biliary cholangitis. A prospective, single centre study.
    Authors:
    Ewa Wunsch, Joanna Raszeja-Wyszomirska, Olivier Barbier, Piotr Milkiewicz
    Conference:
    The International Liver Congress 2017 (rok: 2017, ), Wydawca: European Association for the Study of the Liver
    Data:
    konferencja 19-23.04.2017
    Status:
    Published
    DOI:
    link to the publication
  5. Expression of the fibroblast growth factor 19 (FGF19) in the liver correlates with clinical and laboratory measures in patients with Primary Biliary Cirrhosis.
    Authors:
    E. Wunsch, M. Milkiewicz, A. Kempińska-Podhorodecka, J. Raszeja-Wyszomirska, J. Trottier, O. Barbier, P. Milkiewicz
    Conference:
    The International Liver Congress 2014 (rok: 2014, ), Wydawca: European Association for the Study of the Liver
    Data:
    konferencja 09.04.2014 - 13.04.2014
    Status:
    Published
    DOI:
    link to the publication
  6. POLYMORPHISMS OF IL12RB2 MAY AFFECT THE NATURAL HISTORY OF PRIMARY BILIARY CIRRHOSIS: A SINGLE CENTRE STUDY
    Authors:
    U. Wasik, K. Kozieł, E. Wunsch, G.L. Norman, P. Milkiewicz, M. Milkiewicz
    Conference:
    The International Liver Congress 2016 (rok: 2016, ), Wydawca: European Association for the Study of the Liver
    Data:
    konferencja 13-17.04.2016
    Status:
    Published
    DOI:
    link to the publication
  7. Hepatoprotective effect of S-Adenosyl L-Methionine (SAMe) in oxidative stress: in vitro study on hepatocytes and cholangiocytes
    Authors:
    Ewa Kilanczyk, Piotr Milkiewicz, Jesus M. Banales, Malgorzata Milkiewicz
    Conference:
    EASL Monothematic Conference: Cholangiocytes in health and disease (rok: 2017, ), Wydawca: European Association for the Study of the Liver
    Data:
    konferencja 9-11.06.2017
    Status:
    Published

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