Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Comparative analysis of genetic variations in early onset and adult inflammatory bowel disease in Poland in search for molecular diagnostic application

2011/02/A/NZ5/00339

Keywords:

Crohn disease ulcerative colitis genetic and molecular analyses high-throughput methods molecular diagnostic test

Descriptors:

  • NZ5_5: Diagnostics in human diseases
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Centrum Medyczne Kształcenia Podyplomowego

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jerzy Ostrowski 

Number of co-investigators in the project: 16

Call: MAESTRO 1 - announced on 2011-06-15

Amount awarded: 2 628 000 PLN

Project start date (Y-m-d): 2012-05-18

Project end date (Y-m-d): 2017-11-18

Project duration:: 66 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. System umożliwiający prawidłową pracę aparatu do sekwencjonowania masowego wraz z analizatorem DNA.

Information in the final report

  • Publication in academic press/journals (7)
  • Book publications / chapters in book publications (1)
  1. Transcriptional changes between uninflamed ulcerative colitis and familial adenomatous polyposis pouch mucosa can be attributed to an altered immune response.
    Authors:
    Paziewska A, Horbacka K, Goryca K, Mikula M, Jarosz D, Dabrowska M, Krokowicz P, Karon J, Ostrowski J.
    Academic press:
    Acta Biochim Pol (rok: 2015, tom: 62, strony: 69-75), Wydawca: The Journal of the Polish Biochemical Society and of the Committee of Biochemistry and Biophysics Polish Academy of Science
    Status:
    Published
    DOI:
    10.18388/abp.2014_778 - link to the publication
  2. A novel approach to genome-wide association analysis identifies genetic associations with primary biliary cholangitis and primary sclerosing cholangitis in Polish patients
    Authors:
    Agnieszka Paziewska, Andrzej Habior, Agnieszka Rogowska, Włodzimierz Zych, Krzysztof Goryca, Jakub Karczmarski, Michalina Dabrowska, Filip Ambrozkiewicz, Bozena Walewska-Zielecka, Marek Krawczyk, Halina Cichoz-Lach, Piotr Milkiewicz, Agnieszka Kowalik, Krzysztof Mucha, Joanna Raczynska, Joanna Musialik, Grzegorz Boryczka, Michal Wasilewicz, Irena Ciecko-Michalska, Malgorzata Ferenc, Maria Janiak, Alina Kanikowska, Rafal Stankiewicz, Marek Hartleb, Tomasz Mach, Marian Grzymislawski, Joanna Raszeja-Wyszomirska, Ewa Wunsch, Tomasz Bobinski, Michal Mikula and Jerzy Ostrowski
    Academic press:
    BMC Medical Genomics (rok: 2017, tom: 10, strony: 2), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1186/s12920-016-0239-9 - link to the publication
  3. Genetic architecture differences between pediatric and adult-onset inflammatory bowel diseases in the Polish population
    Authors:
    Jerzy Ostrowski, Agnieszka Paziewska, Izabella Lazowska, Filip Ambrozkiewicz, Krzysztof Goryca, Maria Kulecka, Tomasz Rawa, Jakub Karczmarski, Michalina Dabrowska, Natalia Zeber-Lubecka, Roman Tomecki, Anna Kluska, Aneta Balabas, Magdalena Piatkowska, Katarzyna Paczkowska, Jaroslaw Kierkus, Piotr Socha, Michal Lodyga, Grazyna Rydzewska, Maria Klopocka, Grazyna Mierzwa, Barbara Iwanczak, Elzbieta Krzesiek, Katarzyna Bak-Drabik, Jaroslaw Walkowiak, Beata Klincewicz, Piotr Radwan, Urszula Grzybowska-Chlebowczyk, Piotr Landowski, Agnieszka Jankowska, Bartosz Korczowski, Teresa Starzynska, Piotr Albrecht & Michal Mikula
    Academic press:
    Scientific Reports (rok: 2016, tom: 6, strony: 39831), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/srep39831 - link to the publication
  4. Redefining the practical utility of blood transcriptome biomarkers in inflammatory bowel diseases.
    Authors:
    Ostrowski J, Dabrowska M, Lazowska I, Paziewska A, Balabas A, Kluska A, Kulecka M, Karczmarski J, Ambrozkiewicz F, Piatkowska M, Goryca K, Zeber-Lubecka N, Kierkus J, Socha P, Lodyga M, Klopocka M, Iwanczak B, Bak-Drabik K, Walkowiak J, Radwan P, Grzybowska-Chlebowczyk U, Korczowski B, Starzynska T, Mikula M.
    Academic press:
    J Crohns Colitis (rok: 2019, tom: 13, strony: 626-633), Wydawca: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/ecco-jcc/jjy205 - link to the publication
  5. Combination Testing Using a Single MSH5 Variant alongside HLA Haplotypes Improves the Sensitivity of Predicting Coeliac Disease Risk in the Polish Population.
    Authors:
    Paziewska A, Cukrowska B, Dabrowska M, Goryca K, Piatkowska M, Kluska A, Mikula M, Karczmarski J, Oralewska B, Rybak A, Socha J, Balabas A, Zeber-Lubecka N, Ambrozkiewicz F, Konopka E, Trojanowska I, Zagroba M, Szperl M, Ostrowski J.
    Academic press:
    PLoS One (rok: 2015, tom: e0139197, strony: 45300), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0139197 - link to the publication
  6. A heterozygous mutation in GOT1 is associated with familial macro-aspartate aminotransferase.
    Authors:
    Kulecka M, Wierzbicka A, Paziewska A, Mikula M, Habior A, Janczyk W, Dabrowska M, Karczmarski J, Lazniewski M, Ginalski K, Czlonkowska A, Socha P, Ostrowski J.
    Academic press:
    Journal of Hepatology (rok: 2017, tom: 67, strony: 1026-1030), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jhep.2017.07.003 - link to the publication
  7. Common functional alterations identified in blood transcriptome of autoimmune cholestatic liver and inflammatory bowel diseases
    Authors:
    Ostrowski J, Goryca K, Lazowska I, Rogowska A, Paziewska A, Dabrowska M, Ambrozkiewicz F, Karczmarski J, Balabas A, Kluska A, Piatkowska M, Zeber-Lubecka N, Kulecka M, Habior A, Mikula M
    Academic press:
    Sci Rep (rok: 2019, tom: 9, strony: 7190), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-019-43699-1 - link to the publication
  1. Combination Testing Using a Single MSH5 Variant alongside HLA Haplotypes Improves the Sensitivity of Predicting Coeliac Disease Risk in the Polish Population.
    Authors:
    Paziewska A, Cukrowska B, Dabrowska M, Goryca K, Piatkowska M, Kluska A, Mikula M, Karczmarski J, Oralewska B, Rybak A, Socha J, Balabas A, Zeber-Lubecka N, Ambrozkiewicz F, Konopka E, Trojanowska I, Zagroba M, Szperl M, Ostrowski J.
    Book:
    PLoS One. 2015 Sep 25;10(9):e0139197. doi: 10.1371/journal.pone.0139197. eCollection 2015. (rok: 2015, tom: e0139197, strony: 45300), Wydawca: PLoS
    Status:
    Published
    DOI:
    link to the publication

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