Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Endometrial fibrosis as a potential reason for the implantation disorders and early pregnancy loss in mares: role of sex steroids, prostaglandins, lisophosphatic acid and their receptors in pathogenesis

2011/02/A/NZ5/00338

Keywords:

mare fibrosis endometrium early pregnancy prostaglandins progesteron lisophosphatic acid

Descriptors:

  • NZ5_4: Pathogenesis of animal diseases
  • NZ5_6: Diagnostics in animal diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Rozrodu Zwierząt i Badań Żywności PAN w Olsztynie

woj. warmińsko-mazurskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Dariusz Skarżyński 

Number of co-investigators in the project: 10

Call: MAESTRO 1 - announced on 2011-06-15

Amount awarded: 2 926 000 PLN

Project start date (Y-m-d): 2012-05-11

Project end date (Y-m-d): 2017-05-11

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Zestaw aparatów USG (250 000 PLN)
  2. Zestaw do hodowli tkankowych (90 000 PLN)

Information in the final report

  • Publication in academic press/journals (18)
  • Articles in post-conference publications (28)
  1. Elastase inhibition affects collagen transcription and prostaglandin secretion in mare endometrium during the estrous cycle
    Authors:
    Amaral A, Fernandes C, Lukasik K, Szóstek-Mioduchowska A, Baclawska A, Rebordão MR, Aguiar-Silva J, Pinto-Bravo P, Skarzynski DJ, Ferreira-Dias G.
    Academic press:
    Reproduction in Domestic Animal (rok: 2018, tom: 53 (Suppl 2), strony: 66-69), Wydawca: Springer - ESDAR
    Status:
    Published
    DOI:
    10.1111/rda.13258 - link to the publication
  2. Interleukins affect equine endometrial cell function: modulatory action of ovarian steroids
    Authors:
    Szóstek AZ, Galvão AM, Takuo H, Okuda K, Skarzynski DJ.
    Academic press:
    Mediators of Inflammation (rok: 2014, tom: ID 208103, strony: 11), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2014/208103kk - link to the publication
  3. Role of tumor necrosis factor-α, interferon-γ and Fas-ligand on in vitro nitric oxide activity in the corpus luteum.
    Authors:
    Galvao AM, Szostek AZ, Skarzynski DJ, Ferreira Dias GM.
    Academic press:
    Cytokine (rok: 2013, tom: 64(1), strony: 18-21), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cyto.2013.07.015 - link to the publication
  4. Transforming Growth Factor Beta 1 and Nodal Type I Receptors Activin-Like Kinases 4, 5 and 7 Support Functional Luteolysis in the Mare
    Authors:
    António Galvão, Karolina Wolodko, Maria Rebordão, Dariusz Skarzynski, Graça Ferreira-Dias
    Academic press:
    Biology of Reproduction (rok: 2019, tom: XX, strony: 45321), Wydawca: Society for the Study of Reproduction and Oxford Academic
    Status:
    Submitted
    DOI:
    brak - link to the publication
  5. Is mare endometrosis linked to oviduct fibrosis?
    Authors:
    Pinto-Bravo P, Ferreira-Dias GM, Rebordão MR, Amaral A, Fernandes C, Cuello C, Parrilla I, Martínez E, Roberto da Costa RP, Skarżyński DJ.
    Academic press:
    Pferdeheilkunde (rok: 2018, tom: 34(1), strony: 43-46), Wydawca: Hippiatrika Verlag GmbH Baden-Baden
    Status:
    Published
    DOI:
    10.21836/PEM20180107 - link to the publication
  6. Physiopathologic mechanisms involved in mare endometrosis. Reproduction in Domestic Animals
    Authors:
    Rebordão M, Galvão A, Szóstek A, Amaral A, Mateus L, Skarzynski DJ, Ferreira-Dias G.
    Academic press:
    Reproduction in Domestic Animals (rok: 2014, tom: 49 (Supl 4), strony: 82-87), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1111/rda.12397 - link to the publication
  7. Proteases present in neutrophil extracellular traps may stimulate the fibrogenic PGF2α pathway in the mare endometrium
    Authors:
    Maria Rosa Rebordão, Ana Amaral, Carina Fernandes, Karolina Lukasik, Anna Szóstek-Mioduchowska, Pedro Pinto-Bravo, António Galvão, Dariusz J. Skarzynski, Graça Ferreira-Dias
    Academic press:
    PLOS One (rok: 2019, tom: XX, strony: XX), Wydawca: Public Library of Science
    Status:
    Submitted
    DOI:
    brak - link to the publication
  8. Impairment of the interleukin system in equine endometrium during the course of endometrosis
    Authors:
    Szóstek AZ, Lukasik K, Galvão AM, Ferreira-Dias GM, Skarzynski DJ.
    Academic press:
    Biology of Reproduction (rok: 2013, tom: 89(4):79, ., strony: 1–13), Wydawca: SSR
    Status:
    Published
    DOI:
    10.1095/biolreprod.113.109447 - link to the publication
  9. Ovarian steroids affect prostaglandin production in equine endometrial cells in vitro.
    Authors:
    Szóstek AZ, Galvão AM, Ferreira-Dias GM, Skarzynski DJ.
    Academic press:
    Journal of Endocrinology 2014; 220:3; (rok: 2014, tom: 220(3), strony: 267-276), Wydawca: Society for Endocrinology
    Status:
    Published
    DOI:
    10.1530/JOE-13-0185 - link to the publication
  10. Constituents of neutrophil extracellular traps induce in vitro collagen formation in mare endometrium
    Authors:
    Rebordão MR, Amara, A, Łukasik K, Szóstek-Mioduchowska AZ, Pinto-Bravo P, Galvão AM, Skarżyński DJ, Ferreira-Dias G
    Academic press:
    Theriogenology (rok: 2018, tom: 113, strony: 45522), Wydawca: Elseviere
    Status:
    Published
    DOI:
    10.1016/j.theriogenology.2018.02.001 - link to the publication
  11. Cytokines and Angiogenesis in the Corpus Luteum.
    Authors:
    Galvão AG, Ferreira-Dias G, Skarzynski DJ.
    Academic press:
    Mediators of Inflammation (rok: 2013, tom: ID 420186, strony: 11), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2013/420186 - link to the publication
  12. Nodal promotes functional luteolysis via downregulation of progesterone and prostaglandins E2 and promotion of PGF2alpha synthetic pathways in mare corpus luteum.
    Authors:
    Galvão A, Skarzynski DJ, Ferreira-Dias G.
    Academic press:
    Endocrinology (rok: 2016, tom: 157(2), strony: 858-871), Wydawca: Soc. Endo.
    Status:
    Published
    DOI:
    10.1210/en.2015-1362 - link to the publication
  13. What is new on the physiopathology of endometrosis in the mare?
    Authors:
    Rebordão MR, Galvão AM, Pinto Bravo P, Szóstek A, Skarzynski DJ, Ferreira-Dias G.
    Academic press:
    Pferdeheikunde (rok: 2014, tom: 30(1), strony: 15-18), Wydawca: the German Veterinary Association, section – Equine Medicine
    Status:
    Published
    DOI:
    brak - link to the publication
  14. mRNA transcription of prostaglandin synthases and their products in the equine endometrium in the course of fibrosis.
    Authors:
    Szóstek AZ, Siemieniuch MJ, Lukasik K, Galvão AM, Ferreira-Dias GM & Skarzynski DJ.
    Academic press:
    Theriogenology (rok: 2012, tom: 78(4), strony: 768-776), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.theriogenology.2012.03.024 - link to the publication
  15. Effect of cytokines and ovarian steroids on equine endometrium function: an in vitro study.
    Authors:
    Galvão AM, L Valente L, Skarzynski DJ, Szóstek A, Piotrowska-Tomala K, Rebordão MR, Mateus L, Ferreira-Dias G.
    Academic press:
    Reproduction Fertility and Development (rok: 2013, tom: 25(7), strony: 985-997), Wydawca: CSIRO
    Status:
    Published
    DOI:
    10.1071/RD12153 - link to the publication
  16. Impairment of anti-fibrotic PGE2 pathway may influence neutrophil extracellular traps-induced fibrosis in the mare endometrium
    Authors:
    Rebordão MR, Amaral A, Lukasik K, Szóstek-Mioduchowska A, Pinto-Bravo P, Galvão AM, . Skarżyński DJ, Ferreira-Dias G.
    Academic press:
    Domestic Animal Endocrinology (rok: 2019, tom: 67, strony: 45301), Wydawca: Elseviere
    Status:
    Published
    DOI:
    10.004 - link to the publication
  17. Ovarian steroid-dependent tumor necrosis factor-α production and its action on the equine endometrium in vitro
    Authors:
    Szóstek AZ, Adamowski M, Lukasik K, Galvão AM, Ferreira-Dias GM. & Skarzynski DJ.
    Academic press:
    cytokine (rok: 2014, tom: 67, strony: 85-91), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1016/j.cyto.2014.02.005 - link to the publication
  18. LPA as a regulator of PG secretion in the equine endometrium during the estrous cycle: different effects during endometrosis
    Authors:
    Szóstek-Mioduchowska AZ, Leciejewska N, Zelmańska B, Staszkiewicz-Chodor J, Ferreira-Dias G, Skarzynski DJ
    Academic press:
    Biology of Reproduction (rok: 2019, tom: XX, strony: XX), Wydawca: Society for the Study of Reproduction and Oxford Academic
    Status:
    Submitted
    DOI:
    brak - link to the publication
  1. Influence of interleukin (IL)1α on prostaglandin (PG) production by the equine endometrial cells: modulatory effects of ovarian steroids
    Authors:
    Szóstek AZ, Galvão AM, Ferreira-Dias G, Skarzynski DJ.
    Conference:
    17th Annual Conference on The European Society for Domestic Animals Reproduction, Bologna, Italy (rok: 2013, ), Wydawca: WILEY
    Data:
    konferencja Sept. 11-14, 2013
    Status:
    Published
    DOI:
    link to the publication
  2. Interleukin (IL)1β affects the secretory function of the equine endometrial cells in vitro: modulatory effects of ovarian steroids.
    Authors:
    Szóstek A.Z., Majewska M., Adamowski M., Ferreira-Dias G., Skarzynski D.J.
    Conference:
    The Joint International Congress of the American Society for Reproductive Immunology (ASRI) and the European Society for Reproductive Immunology (ESR). Hamburg, Niemcy (rok: 2012, ), Wydawca: ESRI
    Data:
    konferencja 31.05.-2.06.2012
    Status:
    Published
    DOI:
    link to the publication
  3. MMP-2 and MMP-9 in equine endometrosis
    Authors:
    Szóstek A.Z., Bacławska A., Skarzynski D.J., Okuda K.
    Conference:
    International Conference on Biology and Pathology of Reproduction in Domestic Animals, (rok: 2015, ), Wydawca: IRZBZ PAN
    Data:
    konferencja September 28th-30th, 2015
    Status:
    Published
  4. Neutrophil extracellular traps, cytokines and matrix metalloproteinases: players in endometriosis?
    Authors:
    Rebordão M, Amaral A, Gawronska-Kozak, B, Galvão A, Bravo P, Lukasik K, Skarzynski DJ, Ferreira-Dias G.
    Conference:
    19th Annual Conference on The European Society for Domestic Animals Reproduction (rok: 2015, ), Wydawca: The European Society for Domestic Animals Reproduction
    Data:
    konferencja 16-19 September 2015
    Status:
    Published
  5. Pathways from mare endometritis to endometrosis
    Authors:
    Ferreira-Dias G, M Rebordão, A Galvão, L Mateus, A Szóstek, , DJ Skarzynski
    Conference:
    19th Annual Conference on The European Society for Domestic Animals Reproduction (rok: 2015, ), Wydawca: The European Society for Domestic Animals Reproduction
    Data:
    konferencja 16 th – 19 th September
    Status:
    Published
  6. The modulation of prostaglandin production by coumestrol in the equine endometrium in vitro
    Authors:
    Skarzynski DJ, A.Z. Szóstek, A. Kołomycka, M. Botelho, A. Zagrajczuk and GM. Ferreira- Dias
    Conference:
    XI Symposium on Equine Reproduction, Hamilton, New Zealand (rok: 2014, ), Wydawca: Elsevier
    Data:
    konferencja 26-31.01.2014
    Status:
    Published
  7. Is LPA a luteotropic or luteolitic factor in equine Corpus Luteum?
    Authors:
    Lukasik K, Szostek AZ, Hojo T, Jonczyk A, Skarzynski DJ
    Conference:
    International Conference on Biotechnology and Welfare in Animal Husbandry (rok: 2015, ), Wydawca: UR Kraków
    Data:
    konferencja 15-16 June, 2015
    Status:
    Published
  8. Can pro-fibrotic cytokines (PDGF, TGF-b1 and CTGF) be involves in fibrosis pathways of mare endometrium.
    Authors:
    Rebordao MR, Amaral A, Galvao A, Pinto Bravo P, Lukasik K, Skarzynski DJ
    Conference:
    International Conference on Biotechnology and Welfare in Animal Husbandry (rok: 2015, ), Wydawca: UR Kraków
    Data:
    konferencja 15-16 June, 2015
    Status:
    Published
  9. How challenging is chronic endometritis in the mare?
    Authors:
    Ferreira-Dias G, MR. Rebordão, AZ. Szóstek, AM. Galvão, DJ. Skarzynski
    Conference:
    International Conference on Biology and Pathology of Reproduction in Domestic Animals (rok: 2015, ), Wydawca: IRZBZ PAN
    Data:
    konferencja September 28th-30th, 2015
    Status:
    Published
  10. Lukasik K, Szóstek A, Skarzynski DJ.
    Authors:
    Does endometrosis affect secretory functions of equine CL?
    Conference:
    49 Annual Meeting of Society for the Study of Reproduction (rok: 2016, ), Wydawca: SSR
    Data:
    konferencja 16-20 lipca, San Diego, USA
    Status:
    Published
  11. Ovarian steroid-dependent tumor necrosis factor-α production and its action in equine endometrium in vitro
    Authors:
    Szóstek AZ, M. Adamowski, K. Lukasik, A.M. Galvão, G.M. Ferreira-Dias and D.J. Skarzynski
    Conference:
    XI Symposium on Equine Reproduction, Hamilton, New Zealand (rok: 2014, ), Wydawca: Elsevier
    Data:
    konferencja 26-31.01.2014
    Status:
    Published
  12. The effect of prostaglandins (PGs) and lysophosphatidic acid (LPA) on myometrial motor function and PG and LPA receptors mRNA transcription: preliminary study on the impact of pregnancy and endometrial fibrosis
    Authors:
    Hojo T, AZ Szóstek, KK Piotrowska-Tomala, MJ Siemieniuch, MA Zagrajczuk, DJ Skarzynski
    Conference:
    International Conference on Biology and Pathology of Reproduction in Domestic Animals (rok: 2015, ), Wydawca: IRZBZ PAN
    Data:
    konferencja September 28th-30th, 2015
    Status:
    Published
  13. Whether equine Corpus Luteum is a site for LPA synthesis and/or a target for LPA action?
    Authors:
    Lukasik K, AZ Szostek, J Staszkiewicz, DJ Skarzynski
    Conference:
    Annual Meeting Society for Reproduction and Fertility (rok: 2015, ), Wydawca: Society for Reproduction and Fertility
    Data:
    konferencja 20-22 July, 2015
    Status:
    Published
  14. The effect of 17-β estradiol (E2) and progesterone (P4) on cells proliferation, prostaglandin secretion and prostaglandin (PG) synthases mRNA transcription in the equine endometrial cells in vitro
    Authors:
    Szóstek A.Z., Kołomycka A., Adamowski M., Ferreira-Dias G., Skarzynski D.J.
    Conference:
    The Joint International Congress of the American Society for Reproductive Immunology (ASRI) and the European Society for Reproductive Immunology (ESRI). Hamburg, Niemcy. (rok: 2012, ), Wydawca: ESRI
    Data:
    konferencja 31.05.-2.06.2012
    Status:
    Published
    DOI:
    link to the publication
  15. Wpływ chronicznego degeneracyjnego zwyrodnienie błony śluzowej macicy na funkcje wydzielnicze i profil ekspresji genów w ciałku żółtym klaczy
    Authors:
    Łukasik K, Skarżyński DJ.
    Conference:
    VIII Zjazd Towarzystwa Biologii Rozrodu (rok: 2017, ), Wydawca: Towarzystwo Biologii Rozrodu
    Data:
    konferencja 07-09 września 2017 r.
    Status:
    Published
  16. Endometrial level of lysophosphatidic acid (LPA) and expression of LPA receptors in endometrosis in the mare.
    Authors:
    Szostek A, Karasinka B, Ferreira –Dias G, Skarzynki DJ
    Conference:
    Annual Meeting Society for Reproduction and Fertility (rok: 2015, ), Wydawca: Society for Reproduction and Fertility
    Data:
    konferencja 20-22 July 2015,
    Status:
    Published
  17. Is Nodal a mediator of luteal angiogenesis in the mare?
    Authors:
    Galvao A, Rojewski D, Thomas K, Szostek A, Rebordao MR, Skarzynski DJ
    Conference:
    International Conference on Biotechnology and Welfare in Animal Husbandry (rok: 2015, ), Wydawca: UR Kraków
    Data:
    konferencja 15-16 June 2015
    Status:
    Published
  18. Prostaglandin receptor mRNA transription in equine endometrosis.
    Authors:
    Szostek A, Rebordao MR, Ferreira- Dias GM, Skarzynski DJ.
    Conference:
    International Conference on Biotechnology and Welfare in Animal Husbandry (rok: 2015, ), Wydawca: UR Kraków
    Data:
    konferencja 15-16 June, 2015
    Status:
    Published
  19. Auto-paracrine action of prostaglandins E2 and F2α in equine corpus luteum
    Authors:
    Lukasik K., A. Szóstek, A. Galvao,T. Hojo, K. Okuda and D.J. Skarzynski
    Conference:
    XI Symposium on Equine Reproduction, Hamilton, New Zealand (rok: 2014, ), Wydawca: Elsevier
    Data:
    konferencja 26-31.01.2014
    Status:
    Published
  20. Changes in mRNA Expression of Prostaglandins and Lysophosphatidic Acid Receptors in Equine CL Are Associated with Presence of Chronic Degenerative Endometritis
    Authors:
    Lukasik K, Moza Jalali B, Warmowski P, Skarzynski DJ
    Conference:
    50 Annual Meeting of Society for the Study of Reproduction (rok: 2017, ), Wydawca: Society for the Study of Reproduction and Oxford Academic
    Data:
    konferencja 13-16 lipca 2017
    Status:
    Published
  21. New insights on the oxytocin action in the mare corpus luteum
    Authors:
    Łukasik K, A.Z. Szóstek, K.K. Piotrowska – Tomala, D.J. Skarżyński
    Conference:
    Reproductive Biology, Biotechnology, Animal Welfare and Biodiversity, 2nd Joint German-Polish Conference on Reproductive Medicine, Gdansk (rok: 2013, ), Wydawca: TBR
    Data:
    konferencja 27.02-01.03.2013
    Status:
    Published
    DOI:
    link to the publication
  22. Skarzynski DJ. Szóstek AZ, A Galvão A, Rebordão MR, Ibrahim S, Ferreira-Dias GM.
    Authors:
    Immuno-endocrine regulation of uterine function: modulatory effect of endogenous and exogenous steroids
    Conference:
    20th Annual Conference on The European Society for Domestic Animals Reproduction", , Lisbon, Portuga (rok: 2016, ), Wydawca: ESDAR
    Data:
    konferencja 27-29 X 2016
    Status:
    Published
  23. The expression profiles of leptin and ghrelin, and their respective receptors in equine corpora lutea.
    Authors:
    Galvao AM., A Tramontano, A Mollo , M Rebordão, P Bravo, A Szóstek, D Skarzynski, G Ferreira-Dias
    Conference:
    Ludwig-Fraenkel Symposium: Endocrine Control of Corpus Luteum Function. Wroclaw, Poland (rok: 2013, ), Wydawca: TBR
    Data:
    konferencja Sept, 2013
    Status:
    Published
  24. Nodal promotes luteolysis via downregulation of steroidogenesis in equine corpus luteum
    Authors:
    Galvão AM, Mejer E, Rebordão MR, Pinto Bravo P, Skarzynski DJ, Ferreira-Dias G
    Conference:
    Annual Conference of Society Reproduction & Fertility, Edinburgh, Scotland (rok: 2014, ), Wydawca: Society Reproduction & Fertility
    Data:
    konferencja 02-04.09. 2014
    Status:
    Published
  25. Nodal promotes vascular regression via Thrombospondin-1 pathway during luteolysis in the mare
    Authors:
    Galvão A, K Thomas, A Szóstek, M Rebordão, D Skarzynski, G Ferreira-Dias
    Conference:
    International Conference on Biology and Pathology of Reproduction in Domestic Animals (rok: 2015, ), Wydawca: IRZBZ PAN
    Data:
    konferencja September 28th-30th 2015
    Status:
    Published
  26. The characterization of interleukin 1β in equine endometrium in the course of endometrosis
    Authors:
    AZ Szóstek, K Jankowska,DJ Skarzynski , G Ferreira-Dias
    Conference:
    Reproductive Biology, Biotechnology, Animal Welfare and Biodiversity, 2nd Joint German-Polish Conference on Reproductive Medicine, Gdansk (rok: 2013, ), Wydawca: TBR
    Data:
    konferencja 27.02-01.03.2013
    Status:
    Published
    DOI:
    link to the publication
  27. The effect of transforming growth factor (TGF)-β1 on metalloproteinase and tissue inhibitors of metalloproteinase in equine endometrial cells
    Authors:
    A.Z. Szóstek-Mioduchowska, J. Pacewicz, A. Bacławska, K. Okuda, D.J. Skarzynski
    Conference:
    SRF Sympozium: "Little embryos do make big decisions" (rok: 2017, ), Wydawca: Society for the Reproduction and Fertility
    Data:
    konferencja 7 lipca 2017
    Status:
    Published
  28. Wpływ transformującego czynnika wzrostu (TGF)-β1 na ekspresję i uwalnianie metaloproteinaz i ich tkankowych inhibitorów z komórek nabłonkowych błony śluzowej macicy klaczy
    Authors:
    Szóstek-Mioduchowska AZ, Pacewicz J, Bacławska A, Okuda K, Skarzynski DJ
    Conference:
    VIII Zjazd Towarzystwa Biologii Rozrodu (rok: 2017, ), Wydawca: Towarzystwo Biologii Rozrodu
    Data:
    konferencja 07-09 września 2017 r.
    Status:
    Published

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