Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Characterization of melanospheres derived from clinical melanoma specimens in terms of their capability to recapitulate parental tumor phenotype, the frequency of cells with stem cell-like properties, and response to changes in microenvironment, including potential anticancer drugs

2011/01/B/NZ4/04921

Keywords:

cancer stem cells melanoma natural drugs,

Descriptors:

  • NZ4_11: Metabolism

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Małgorzata Czyż 

Number of co-investigators in the project: 7

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 1 020 000 PLN

Project start date (Y-m-d): 2011-12-16

Project end date (Y-m-d): 2014-12-15

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. cytometr przepływowy (430 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. MITF in melanoma - mechanisms behind its expression and activity
    Authors:
    Mariusz L Hartman, Malgorzata Czyz
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2014, tom: Epub, strony: 2014 Nov 30. [Epub ahead of print]), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-014-1791-0 - link to the publication
  2. Sphere formation and self-renewal capacity of melanoma cells is affected by the microenvironment
    Authors:
    Malgorzata Sztiller-Sikorska, Kamila Koprowska, Justyna Jakubowska, Izabela Zalesna, Marta Stasiak, Markus Duechler and Malgorzata Ewa Czyz
    Academic press:
    Melanoma Research (rok: 2012, tom: 22, strony: 215-224), Wydawca: Lippincott Williams & Wilkins
    Status:
    Published
    DOI:
    10.1097/CMR.0b013e3283531317 - link to the publication
  3. Phenotypic diversity of patient-derived melanoma populations in stem cell medium
    Authors:
    Malgorzata Sztiller-Sikorska, Mariusz L. Hartman, Beata Talar, Justyna Jakubowska, Izabela Zalesna, Malgorzata Czyz
    Academic press:
    Laboratory Investigation (rok: 2015, tom: 95, strony: 672-683), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/labinvest.2015.48 - link to the publication
  4. Natural Compounds' Activity against Cancer Stem-Like or Fast-Cycling Melanoma Cells
    Authors:
    Sztiller-Sikorska M, Koprowska K, Majchrzak K, Hartman M, Czyz M
    Academic press:
    PLoS ONE (rok: 2014, tom: 9 (3), strony: e90783), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0090783 - link to the publication
  5. Pro-apoptotic Activity of BH3-only Proteins and BH3 Mimetics: from Theory to Potential Cancer Therapy
    Authors:
    Mariusz L. Hartman and Malgorzata Czyz
    Academic press:
    Anti-Cancer Agents in Medicinal Chemistry (rok: 2012, tom: 12, strony: 966-981), Wydawca: Bentham Science Publishers
    Status:
    Published
    DOI:
    brak - link to the publication
  6. Anti-apoptotic proteins on guard of melanoma cell survival
    Authors:
    Mariusz L. Hartman, Malgorzata Czyz
    Academic press:
    Cancer Letters (rok: 2013, tom: 331, strony: 24-34), Wydawca: Elsevier Ireland Ltd
    Status:
    Published
    DOI:
    10.1016/j.canlet.2013.01.010 - link to the publication
  7. Parthenolide reduces the frequency of ABCB5-positive cells and clonogenic capacity of melanoma cells from anchorage independent melanospheres
    Authors:
    Malgorzata Czyz, Kamila Koprowska and Malgorzata Sztiller-Sikorska
    Academic press:
    Cancer Biology & Therapy (rok: 2013, tom: 14, strony: 135-145), Wydawca: www.landesbioscience.com
    Status:
    Published
    DOI:
    10.4161/cbt.22952 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy